HCSGD entry for ERCC4

1. General information

Official gene symbolERCC4
Entrez ID2072
Gene full nameexcision repair cross-complementing rodent repair deficiency, complementation group 4
Other gene symbolsERCC11 FANCQ RAD1 XPF
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000014Single-stranded DNA endodeoxyribonuclease activityIBAmolecular_function
GO:0000109Nucleotide-excision repair complexIDAcellular_component
GO:0000110Nucleotide-excision repair factor 1 complexIDAcellular_component
GO:0000710Meiotic mismatch repairIBAbiological_process
GO:0000712Resolution of meiotic recombination intermediatesIBAbiological_process
GO:0000718Nucleotide-excision repair, DNA damage removalTASbiological_process
GO:0000723Telomere maintenanceIMPbiological_process
GO:0000724Double-strand break repair via homologous recombinationIMPbiological_process
GO:0000737DNA catabolic process, endonucleolyticIBA IDAbiological_process
GO:0000781Chromosome, telomeric regionIDAcellular_component
GO:0000784Nuclear chromosome, telomeric regionIDAcellular_component
GO:0001094TFIID-class transcription factor bindingIEAmolecular_function
GO:0003684Damaged DNA bindingIMPmolecular_function
GO:0003697Single-stranded DNA bindingIDAmolecular_function
GO:0004520Endodeoxyribonuclease activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005669Transcription factor TFIID complexIEAcellular_component
GO:0006281DNA repairIMP TASbiological_process
GO:0006283Transcription-coupled nucleotide-excision repairTASbiological_process
GO:0006289Nucleotide-excision repairIDA IMP TASbiological_process
GO:0006295Nucleotide-excision repair, DNA incision, 3'-to lesionIMPbiological_process
GO:0006296Nucleotide-excision repair, DNA incision, 5'-to lesionIMPbiological_process
GO:0008022Protein C-terminus bindingIPImolecular_function
GO:0009411Response to UVIMPbiological_process
GO:0009650UV protectionIEAbiological_process
GO:0010834Telomere maintenance via telomere shorteningIMPbiological_process
GO:0032205Negative regulation of telomere maintenanceIMPbiological_process
GO:0033683Nucleotide-excision repair, DNA incisionIDAbiological_process
GO:0043566Structure-specific DNA bindingIDAmolecular_function
GO:0047485Protein N-terminus bindingIPImolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.92486835230.18480400440.99999024730.8332587359

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0428585469
GSE13712_SHEARDown-0.2616502286
GSE13712_STATICDown-0.0767688039
GSE19018Down-0.3187554141
GSE19899_A1Down-0.2212065343
GSE19899_A2Down-0.1416444569
PubMed_21979375_A1Up0.1582242237
PubMed_21979375_A2Up0.1336783934
GSE35957Down-0.2431650116
GSE36640Up0.0925677503
GSE54402Up0.0637847611
GSE9593Down-0.3248516558
GSE43922Down-0.1104335704
GSE24585Down-0.0696024680
GSE37065Up0.0899911912
GSE28863_A1Up0.0604681845
GSE28863_A2Up0.1519490452
GSE28863_A3Down-0.5073448178
GSE28863_A4Down-0.0945371029
GSE48662Up0.0071475009

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-192-5pMIMAT0000222MIRT006456Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI21672525
hsa-miR-192-5pMIMAT0000222MIRT006456MicroarrayFunctional MTI (Weak)19074876
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.