HCSGD entry for EREG

1. General information

Official gene symbolEREG
Entrez ID2069
Gene full nameepiregulin
Other gene symbolsER
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001525AngiogenesisIEAbiological_process
GO:0001550Ovarian cumulus expansionISSbiological_process
GO:0001556Oocyte maturationISSbiological_process
GO:0001819Positive regulation of cytokine productionISSbiological_process
GO:0005154Epidermal growth factor receptor bindingISS TASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005615Extracellular spaceIDAcellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0007143Female meiosisISSbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayISS TASbiological_process
GO:0007267Cell-cell signalingIDAbiological_process
GO:0008083Growth factor activityIEAmolecular_function
GO:0008284Positive regulation of cell proliferationIDA ISSbiological_process
GO:0008285Negative regulation of cell proliferationISSbiological_process
GO:0008543Fibroblast growth factor receptor signaling pathwayTASbiological_process
GO:0009299MRNA transcriptionIDAbiological_process
GO:0009653Anatomical structure morphogenesisTASbiological_process
GO:0009887Organ morphogenesisTASbiological_process
GO:0019221Cytokine-mediated signaling pathwayIDAbiological_process
GO:0030216Keratinocyte differentiationTASbiological_process
GO:0030728OvulationISSbiological_process
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0042060Wound healingTASbiological_process
GO:0042108Positive regulation of cytokine biosynthetic processIDAbiological_process
GO:0042327Positive regulation of phosphorylationIDA ISSbiological_process
GO:0042700Luteinizing hormone signaling pathwayISSbiological_process
GO:0043434Response to peptide hormoneIEAbiological_process
GO:0043616Keratinocyte proliferationIDAbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045089Positive regulation of innate immune responseISSbiological_process
GO:0045410Positive regulation of interleukin-6 biosynthetic processISSbiological_process
GO:0045740Positive regulation of DNA replicationIDA ISSbiological_process
GO:0045741Positive regulation of epidermal growth factor-activated receptor activityISSbiological_process
GO:0045840Positive regulation of mitosisISSbiological_process
GO:0045860Positive regulation of protein kinase activityIDAbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIDAbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0048015Phosphatidylinositol-mediated signalingTASbiological_process
GO:0048146Positive regulation of fibroblast proliferationIDAbiological_process
GO:0048160Primary follicle stageISSbiological_process
GO:0048661Positive regulation of smooth muscle cell proliferationISSbiological_process
GO:0050680Negative regulation of epithelial cell proliferationTASbiological_process
GO:0051151Negative regulation of smooth muscle cell differentiationIDAbiological_process
GO:0051781Positive regulation of cell divisionIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00010042930.96696019150.02812127661.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up1.6274412631
GSE13712_SHEARDown-0.0727548034
GSE13712_STATICDown-0.0584061794
GSE19018Up0.0785210055
GSE19899_A1Up3.3702610365
GSE19899_A2Up2.6994287090
PubMed_21979375_A1Up5.1630332649
PubMed_21979375_A2Up3.5105783947
GSE35957Up0.7605061501
GSE36640Up0.3677870867
GSE54402Up1.6975114061
GSE9593Up0.0336743777
GSE43922Up4.2243355895
GSE24585Up0.0113884721
GSE37065Up0.9360440532
GSE28863_A1Down-0.0277921173
GSE28863_A2Up0.0233735457
GSE28863_A3Up0.1901287799
GSE28863_A4Up0.0615687506
GSE48662Down-0.2672185353

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT016703MicroarrayFunctional MTI (Weak)18185580
hsa-miR-124-3pMIMAT0000422MIRT022139MicroarrayFunctional MTI (Weak)18668037
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.