HCSGD entry for EPRS
1. General information
| Official gene symbol | EPRS |
|---|---|
| Entrez ID | 2058 |
| Gene full name | glutamyl-prolyl-tRNA synthetase |
| Other gene symbols | EARS GLUPRORS PARS QARS QPRS |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004818 | Glutamate-tRNA ligase activity | TAS | molecular_function |
| GO:0004827 | Proline-tRNA ligase activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005737 | Cytoplasm | TAS | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006418 | TRNA aminoacylation for protein translation | TAS | biological_process |
| GO:0006424 | Glutamyl-tRNA aminoacylation | IEA | biological_process |
| GO:0006433 | Prolyl-tRNA aminoacylation | IEA | biological_process |
| GO:0006461 | Protein complex assembly | TAS | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0017148 | Negative regulation of translation | IDA IMP | biological_process |
| GO:0030529 | Ribonucleoprotein complex | IDA | cellular_component |
| GO:0035613 | RNA stem-loop binding | IDA | molecular_function |
| GO:0071346 | Cellular response to interferon-gamma | IDA | biological_process |
| GO:0097452 | GAIT complex | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0819785950 | 0.4789831807 | 0.6036033287 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0375400174 |
| GSE13712_SHEAR | Up | 0.0071055799 |
| GSE13712_STATIC | Up | 0.0652397705 |
| GSE19018 | Up | 0.5109742252 |
| GSE19899_A1 | Up | 0.4224656992 |
| GSE19899_A2 | Down | -0.1565851861 |
| PubMed_21979375_A1 | Up | 0.0949964118 |
| PubMed_21979375_A2 | Down | -0.6012355188 |
| GSE35957 | Down | -0.0991233889 |
| GSE36640 | Up | 0.2451976540 |
| GSE54402 | Up | 0.0010013257 |
| GSE9593 | Up | 0.6472731484 |
| GSE43922 | Up | 0.1042850006 |
| GSE24585 | Down | -0.3007833004 |
| GSE37065 | Down | -0.3007033648 |
| GSE28863_A1 | Up | 0.5932323860 |
| GSE28863_A2 | Up | 0.7172289252 |
| GSE28863_A3 | Up | 0.0217770508 |
| GSE28863_A4 | Down | -0.1907846214 |
| GSE48662 | Down | -0.3370967333 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| L-Glutamic Acid | DB00142 | NUTR00027 |
| '5'-O-(N-(L-Prolyl)-Sulfamoyl)Adenosine | DB02510 | EXPT02481 |
| 5'-O-(N-(L-Cysteinyl)-Sulfamoyl)Adenosine | DB02684 | EXPT00241 |
| '5'-O-(N-(L-Alanyl)-Sulfamoyl)Adenosine | DB03376 | EXPT00374 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | MIRT021005 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-140-3p | MIMAT0004597 | MIRT038646 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041245 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
