HCSGD entry for CLN8

1. General information

Official gene symbolCLN8
Entrez ID2055
Gene full nameceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
Other gene symbolsC8orf61 EPMR
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001306Age-dependent response to oxidative stressIEAbiological_process
GO:0005739MitochondrionIEAcellular_component
GO:0005783Endoplasmic reticulumIDAcellular_component
GO:0005789Endoplasmic reticulum membraneIEAcellular_component
GO:0005793Endoplasmic reticulum-Golgi intermediate compartmentIDAcellular_component
GO:0006644Phospholipid metabolic processIMPbiological_process
GO:0006672Ceramide metabolic processIMPbiological_process
GO:0006869Lipid transportNASbiological_process
GO:0007006Mitochondrial membrane organizationIEAbiological_process
GO:0007040Lysosome organizationIEAbiological_process
GO:0007399Nervous system developmentIMPbiological_process
GO:0007601Visual perceptionIEAbiological_process
GO:0007628Adult walking behaviorIEAbiological_process
GO:0008203Cholesterol metabolic processIMPbiological_process
GO:0008219Cell deathIEAbiological_process
GO:0008306Associative learningIEAbiological_process
GO:0008361Regulation of cell sizeIEAbiological_process
GO:0008610Lipid biosynthetic processNASbiological_process
GO:0016021Integral component of membraneNAScellular_component
GO:0021523Somatic motor neuron differentiationIEAbiological_process
GO:0030163Protein catabolic processNASbiological_process
GO:0033116Endoplasmic reticulum-Golgi intermediate compartment membraneIEAcellular_component
GO:0035176Social behaviorIEAbiological_process
GO:0043066Negative regulation of apoptotic processIEAbiological_process
GO:0044257Cellular protein catabolic processIEAbiological_process
GO:0045494Photoreceptor cell maintenanceIEAbiological_process
GO:0045861Negative regulation of proteolysisNASbiological_process
GO:0046513Ceramide biosynthetic processNASbiological_process
GO:0050881Musculoskeletal movementIEAbiological_process
GO:0050884Neuromuscular process controlling postureIEAbiological_process
GO:0050885Neuromuscular process controlling balanceIEAbiological_process
GO:0051348Negative regulation of transferase activityIEAbiological_process
GO:0051935L-glutamate uptake involved in synaptic transmissionIEAbiological_process
GO:0060041Retina development in camera-type eyeIEAbiological_process
GO:0060052Neurofilament cytoskeleton organizationIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00707022910.87060695260.21945224061.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.3425938905
GSE13712_SHEARDown-0.1989707803
GSE13712_STATICDown-0.3826541158
GSE19018Up0.0266671419
GSE19899_A1Up0.4243864545
GSE19899_A2Up1.2062502808
PubMed_21979375_A1Up0.7485138186
PubMed_21979375_A2Up1.3185372702
GSE35957Up0.6856606026
GSE36640Up1.4719582116
GSE54402Up0.3231279860
GSE9593Up0.6579512550
GSE43922Up0.6763674219
GSE24585Down-0.3230129189
GSE37065Down-0.0338737159
GSE28863_A1Down-0.1165537263
GSE28863_A2Up0.3211352904
GSE28863_A3Down-0.4341929998
GSE28863_A4Down-0.3031915481
GSE48662Up0.2914103121

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-484MIMAT0002174MIRT041713CLASHFunctional MTI (Weak)23622248
hsa-miR-93-5pMIMAT0000093MIRT048849CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.