HCSGD entry for STX2
1. General information
| Official gene symbol | STX2 |
|---|---|
| Entrez ID | 2054 |
| Gene full name | syntaxin 2 |
| Other gene symbols | EPIM EPM STX2A STX2B STX2C |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005484 | SNAP receptor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005911 | Cell-cell junction | IEA | cellular_component |
| GO:0006886 | Intracellular protein transport | IEA | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0007340 | Acrosome reaction | ISS | biological_process |
| GO:0007398 | Ectoderm development | TAS | biological_process |
| GO:0009887 | Organ morphogenesis | TAS | biological_process |
| GO:0009986 | Cell surface | IEA | cellular_component |
| GO:0016020 | Membrane | IEA | cellular_component |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016192 | Vesicle-mediated transport | IEA | biological_process |
| GO:0016323 | Basolateral plasma membrane | IDA | cellular_component |
| GO:0030154 | Cell differentiation | IEA | biological_process |
| GO:0031410 | Cytoplasmic vesicle | IEA | cellular_component |
| GO:0043231 | Intracellular membrane-bounded organelle | TAS | cellular_component |
| GO:0045121 | Membrane raft | IEA | cellular_component |
| GO:0048306 | Calcium-dependent protein binding | ISS | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9122993579 | 0.0488657118 | 0.9999902473 | 0.4134343941 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2651961270 |
| GSE13712_SHEAR | Down | -0.1778561513 |
| GSE13712_STATIC | Down | -0.0091744058 |
| GSE19018 | Up | 0.2557773437 |
| GSE19899_A1 | Down | -0.6081822274 |
| GSE19899_A2 | Down | -0.4127239638 |
| PubMed_21979375_A1 | Down | -0.5735952439 |
| PubMed_21979375_A2 | Down | -0.4193239883 |
| GSE35957 | Down | -0.0184870323 |
| GSE36640 | Down | -0.2547577858 |
| GSE54402 | Down | -0.0878183655 |
| GSE9593 | Up | 0.3565666009 |
| GSE43922 | Down | -0.3719560862 |
| GSE24585 | Down | -0.3193418591 |
| GSE37065 | Down | -0.2010523574 |
| GSE28863_A1 | Down | -0.3432219755 |
| GSE28863_A2 | Down | -0.0430689051 |
| GSE28863_A3 | Down | -0.0695293956 |
| GSE28863_A4 | Up | 0.2274876192 |
| GSE48662 | Up | 0.7238853203 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT002690 | Microarray | Functional MTI (Weak) | 15685193 |
| hsa-miR-3200-3p | MIMAT0015085 | MIRT052827 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 12829466 | A recent model for depletion-mediated RBC aggregation was employed to calculate the changes of glycocalyx properties that were consistent with experimental electrophoretic mobility (EPM) and aggregation data |
| 12829466 | Young and old cells were obtained by density separation, after which aggregation and EPM were determined versus ionic strength; old cells exhibited a two- to threefold greater aggregation in dextran |
| 12829466 | EPM of old cells was identical to young cells in polymer-free media yet was 4% greater in dextran |
| 12829466 | The greater EPM for old RBC indicates a larger polymer depletion layer, which could be explained either by a 10-15% decrease of their glycocalyx thickness or a similar percentage decrease of polymer penetration into their glycocalyx |
| 12829466 | These results provide a rational explanation for the aggregation and EPM behavior of old RBC, and raise the possibility of depletion-mediated interactions contributing to senescent cell removal from the circulation |
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