HCSGD entry for EPHX2

1. General information

Official gene symbolEPHX2
Entrez ID2053
Gene full nameepoxide hydrolase 2, cytoplasmic
Other gene symbolsCEH SEH
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000287Magnesium ion bindingIDAmolecular_function
GO:0003824Catalytic activityIEAmolecular_function
GO:0004301Epoxide hydrolase activityIDA TASmolecular_function
GO:0005102Receptor bindingIPImolecular_function
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005777PeroxisomeIDAcellular_component
GO:0005794Golgi apparatusIDAcellular_component
GO:0005829CytosolIDA NAS TAScellular_component
GO:0005925Focal adhesionIDAcellular_component
GO:0006805Xenobiotic metabolic processNASbiological_process
GO:0006874Cellular calcium ion homeostasisNASbiological_process
GO:0006954Inflammatory responseNASbiological_process
GO:0008217Regulation of blood pressureNASbiological_process
GO:0009636Response to toxic substanceNASbiological_process
GO:0010628Positive regulation of gene expressionIDA IEAbiological_process
GO:0015643Toxic substance bindingIDAmolecular_function
GO:0016311DephosphorylationIDAbiological_process
GO:0016787Hydrolase activityIEAmolecular_function
GO:0016791Phosphatase activityIDAmolecular_function
GO:0017144Drug metabolic processNASbiological_process
GO:0019369Arachidonic acid metabolic processTASbiological_process
GO:0019373Epoxygenase P450 pathwayTASbiological_process
GO:003388510-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activityIEAmolecular_function
GO:0042577Lipid phosphatase activityIDAmolecular_function
GO:0042632Cholesterol homeostasisIDA IEAbiological_process
GO:0042803Protein homodimerization activityIDA NASmolecular_function
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045909Positive regulation of vasodilationNASbiological_process
GO:0046272Stilbene catabolic processIDAbiological_process
GO:0046839Phospholipid dephosphorylationIDAbiological_process
GO:0072593Reactive oxygen species metabolic processNASbiological_process
GO:0090181Regulation of cholesterol metabolic processIEA IMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.79364645720.29601137110.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0536325455
GSE13712_SHEARDown-0.0299509821
GSE13712_STATICDown-0.1494281489
GSE19018Up0.1203285592
GSE19899_A1Down-0.0468712359
GSE19899_A2Up0.0462047061
PubMed_21979375_A1Up0.0040649937
PubMed_21979375_A2Down-0.1157330423
GSE35957Down-0.0352708947
GSE36640Up0.0571705577
GSE54402Down-0.1538306603
GSE9593Down-0.0959118262
GSE43922Up0.0116742921
GSE24585Up0.2925452459
GSE37065Up0.0010805349
GSE28863_A1Down-0.1512288675
GSE28863_A2Down-0.3152887570
GSE28863_A3Down-0.0302873691
GSE28863_A4Up0.0267981490
GSE48662Up0.1068419034

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

N-Cyclohexyl-N'-(4-Iodophenyl)UreaDB02029 EXPT00923
N-Cyclohexyl-N'-DecylureaDB03677 EXPT00878
N-Cyclohexyl-N'-(Propyl)Phenyl UreaDB04213 EXPT01006
N-[(CYCLOHEXYLAMINO)CARBONYL]GLYCINEDB08256 -
4-{[(CYCLOHEXYLAMINO)CARBONYL]AMINO}BUTANOIC ACIDDB08257 -
6-{[(CYCLOHEXYLAMINO)CARBONYL]AMINO}HEXANOIC ACIDDB08258 -
7-{[(CYCLOHEXYLAMINO)CARBONYL]AMINO}HEPTANOIC ACIDDB08259 -

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.