HCSGD entry for EPHB4

1. General information

Official gene symbolEPHB4
Entrez ID2050
Gene full nameEPH receptor B4
Other gene symbolsHTK MYK1 TYRO11
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001525AngiogenesisISSbiological_process
GO:0002042Cell migration involved in sprouting angiogenesisIDAbiological_process
GO:0003007Heart morphogenesisISSbiological_process
GO:0004714Transmembrane receptor protein tyrosine kinase activityIDAmolecular_function
GO:0005003Ephrin receptor activityIDA IEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005887Integral component of plasma membraneIDA IEAcellular_component
GO:0007155Cell adhesionIDAbiological_process
GO:0018108Peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0046777Protein autophosphorylationIDAbiological_process
GO:0048013Ephrin receptor signaling pathwayIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.97402784850.01017066980.99999024730.2000763827

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1421975846
GSE13712_SHEARDown-0.4462992944
GSE13712_STATICDown-0.1841155767
GSE19018Up0.1698809451
GSE19899_A1Down-0.2584573273
GSE19899_A2Down-0.5955445291
PubMed_21979375_A1Down-1.1830803597
PubMed_21979375_A2Down-0.4750298901
GSE35957Down-0.6244104664
GSE36640Down-0.4668563166
GSE54402Down-0.6115881682
GSE9593Down-0.4986000334
GSE43922Down-0.3293137583
GSE24585Down-0.2972539786
GSE37065Down-0.3051729887
GSE28863_A1Up0.3125754287
GSE28863_A2Up0.7028527418
GSE28863_A3Down-0.1649147845
GSE28863_A4Down-0.2750969609
GSE48662Up0.1422728479

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

XL647DB05007 -
N-(5-chloro-1,3-benzodioxol-4-yl)-6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-amineDB07249 -
N'-(5-CHLORO-1,3-BENZODIOXOL-4-YL)-N-(3,4,5- TRIMETHOXYPHENYL)PYRIMIDINE-2,4-DIAMINEDB07250 -
N'-(3-CHLORO-4-METHOXY-PHENYL)-N-(3,4,5-TRIMETHOXYPHENYL)-1,3,5-TRIAZINE-2,4-DIAMINEDB07251 -
3-({4-[(5-chloro-1,3-benzodioxol-4-yl)amino]pyrimidin-2-yl}amino)benzenesulfonamideDB07252 -
N'-(5-chloro-1,3-benzodioxol-4-yl)-N-(3-methylsulfonylphenyl)pyrimidine-2,4-diamineDB07253 -
N-[3-[[4-[(5-CHLORO-1,3-BENZODIOXOL-4-YL)AMINO]PYRIMIDIN-2-YL]AMINO]PHENYL]METHANESULFONAMIDEDB07254 -
N'-(5-CHLORO-1,3-BENZODIOXOL-4-YL)-N-(3-MORPHOLIN-4-YLPHENYL)PYRIMIDINE-2,4-DIAMINEDB07255 -
3-({4-[(5-CHLORO-1,3-BENZODIOXOL-4-YL)AMINO]PYRIMIDIN-2-YL}AMINO)BENZAMIDEDB07256 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-20b-5pMIMAT0001413MIRT006338Luciferase reporter assayFunctional MTI22438230
hsa-miR-335-5pMIMAT0000765MIRT017978MicroarrayFunctional MTI (Weak)18185580
hsa-miR-93-3pMIMAT0004509MIRT038783CLASHFunctional MTI (Weak)23622248
hsa-miR-1260bMIMAT0015041MIRT052757CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.