HCSGD entry for EPHA4

1. General information

Official gene symbolEPHA4
Entrez ID2043
Gene full nameEPH receptor A4
Other gene symbolsHEK8 SEK TYRO1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004672Protein kinase activityIDA IEAmolecular_function
GO:0005003Ephrin receptor activityIEAmolecular_function
GO:0005004GPI-linked ephrin receptor activityIEA ISSmolecular_function
GO:0005005Transmembrane-ephrin receptor activityIEA ISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005737CytoplasmISScellular_component
GO:0005741Mitochondrial outer membraneIEAcellular_component
GO:0005783Endoplasmic reticulumIEAcellular_component
GO:0005794Golgi apparatusIEAcellular_component
GO:0005887Integral component of plasma membraneIEA ISScellular_component
GO:0007155Cell adhesionIEAbiological_process
GO:0007628Adult walking behaviorIEAbiological_process
GO:0008045Motor neuron axon guidanceIEA ISSbiological_process
GO:0008347Glial cell migrationIEAbiological_process
GO:0009986Cell surfaceIEAcellular_component
GO:0014069Postsynaptic densityIEAcellular_component
GO:0018108Peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0021957Corticospinal tract morphogenesisIEA ISSbiological_process
GO:0030054Cell junctionIEAcellular_component
GO:0030175FilopodiumIEAcellular_component
GO:0030424AxonISScellular_component
GO:0030425DendriteISScellular_component
GO:0031594Neuromuscular junctionIEAcellular_component
GO:0031901Early endosome membraneIEA ISScellular_component
GO:0032314Regulation of Rac GTPase activityIEA ISSbiological_process
GO:0032317Regulation of Rap GTPase activityIEA ISSbiological_process
GO:0042731PH domain bindingIPImolecular_function
GO:0042802Identical protein bindingIEAmolecular_function
GO:0043197Dendritic spineIEAcellular_component
GO:0043204PerikaryonIEAcellular_component
GO:0043507Positive regulation of JUN kinase activityIEAbiological_process
GO:0043679Axon terminusIEAcellular_component
GO:0044295Axonal growth coneIEAcellular_component
GO:0045211Postsynaptic membraneIEAcellular_component
GO:0046777Protein autophosphorylationIDAbiological_process
GO:0046875Ephrin receptor bindingIEAmolecular_function
GO:0048681Negative regulation of axon regenerationIEA ISSbiological_process
GO:0048710Regulation of astrocyte differentiationIEA ISSbiological_process
GO:0050770Regulation of axonogenesisIEA ISSbiological_process
GO:0050775Positive regulation of dendrite morphogenesisIEAbiological_process
GO:0061001Regulation of dendritic spine morphogenesisIEA ISSbiological_process
GO:0097155Fasciculation of sensory neuron axonIEA ISSbiological_process
GO:0097156Fasciculation of motor neuron axonIEA ISSbiological_process
GO:0097161DH domain bindingIDAmolecular_function
GO:2001108Positive regulation of Rho guanyl-nucleotide exchange factor activityIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.05225421530.11428128490.50021057800.6483389283

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0891724392
GSE13712_SHEARUp0.4146902428
GSE13712_STATICUp0.1831200458
GSE19018Down-0.5848338259
GSE19899_A1Up0.4481055233
GSE19899_A2Up0.1007161020
PubMed_21979375_A1Down-0.1085260237
PubMed_21979375_A2Up1.4475644959
GSE35957Up0.1036428137
GSE36640Up0.8870075870
GSE54402Down-1.6556768641
GSE9593Up0.2207931736
GSE43922Down-0.0081934376
GSE24585Down-0.1860502798
GSE37065Up0.2434392939
GSE28863_A1Up0.9941396605
GSE28863_A2Down-0.0804057480
GSE28863_A3Down-0.8400698962
GSE28863_A4Down-0.3848564790
GSE48662Up0.2293697867

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-10a-5pMIMAT0000253MIRT006972GFP reporter assay//Immunohistochemistry//qRT-PCR//Western blotFunctional MTI22996586
hsa-miR-10a-5pMIMAT0000253MIRT006972CLASHFunctional MTI (Weak)23622248
hsa-miR-335-5pMIMAT0000765MIRT016908MicroarrayFunctional MTI (Weak)18185580
hsa-miR-130b-3pMIMAT0000691MIRT020126SequencingFunctional MTI (Weak)20371350
hsa-miR-132-3pMIMAT0000426MIRT021734MicroarrayFunctional MTI (Weak)17612493
hsa-miR-93-5pMIMAT0000093MIRT027959SequencingFunctional MTI (Weak)20371350
hsa-miR-93-5pMIMAT0000093MIRT027959CLASHFunctional MTI (Weak)23622248
hsa-miR-21-5pMIMAT0000076MIRT030703MicroarrayFunctional MTI (Weak)18591254
hsa-miR-505-3pMIMAT0002876MIRT041039CLASHFunctional MTI (Weak)23622248
hsa-miR-361-5pMIMAT0000703MIRT044104CLASHFunctional MTI (Weak)23622248
hsa-miR-320aMIMAT0000510MIRT044406CLASHFunctional MTI (Weak)23622248
hsa-miR-10b-5pMIMAT0000254MIRT047479CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049304CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.