HCSGD entry for DMTN

1. General information

Official gene symbolDMTN
Entrez ID2039
Gene full namedematin actin binding protein
Other gene symbolsDMT EPB49
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003779Actin bindingIDA IEAmolecular_function
GO:0005102Receptor bindingIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolIDAcellular_component
GO:0005884Actin filamentIDAcellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0006461Protein complex assemblyIDA IEA ISSbiological_process
GO:0007010Cytoskeleton organizationTASbiological_process
GO:0008360Regulation of cell shapeIMPbiological_process
GO:0010591Regulation of lamellipodium assemblyIMPbiological_process
GO:0010763Positive regulation of fibroblast migrationIEA ISSbiological_process
GO:0010801Negative regulation of peptidyl-threonine phosphorylationIEA ISSbiological_process
GO:0010812Negative regulation of cell-substrate adhesionISSbiological_process
GO:0012505Endomembrane systemIEAcellular_component
GO:0014731Spectrin-associated cytoskeletonIDAcellular_component
GO:0015629Actin cytoskeletonTAScellular_component
GO:0016023Cytoplasmic membrane-bounded vesicleIDAcellular_component
GO:0030036Actin cytoskeleton organizationIEA ISSbiological_process
GO:0030194Positive regulation of blood coagulationIEA ISSbiological_process
GO:0030507Spectrin bindingIDAmolecular_function
GO:0030863Cortical cytoskeletonIEAcellular_component
GO:0031095Platelet dense tubular network membraneIDAcellular_component
GO:0031253Cell projection membraneIEA ISScellular_component
GO:0032956Regulation of actin cytoskeleton organizationIDAbiological_process
GO:0033137Negative regulation of peptidyl-serine phosphorylationIEA ISSbiological_process
GO:0035584Calcium-mediated signaling using intracellular calcium sourceIEA ISSbiological_process
GO:0035585Calcium-mediated signaling using extracellular calcium sourceIEA ISSbiological_process
GO:0043621Protein self-associationIDAmolecular_function
GO:0048471Perinuclear region of cytoplasmIEA ISScellular_component
GO:0048821Erythrocyte developmentIEA ISSbiological_process
GO:0050732Negative regulation of peptidyl-tyrosine phosphorylationIEA ISSbiological_process
GO:0051017Actin filament bundle assemblyIDA TASbiological_process
GO:0051489Regulation of filopodium assemblyIMPbiological_process
GO:0051693Actin filament cappingIEAbiological_process
GO:0051895Negative regulation of focal adhesion assemblyIEA ISSbiological_process
GO:0070560Protein secretion by plateletIEA ISSbiological_process
GO:0071277Cellular response to calcium ionIEA ISSbiological_process
GO:0071320Cellular response to cAMPIDAbiological_process
GO:0090303Positive regulation of wound healingIEA ISSbiological_process
GO:0090315Negative regulation of protein targeting to membraneIEA ISSbiological_process
GO:0090527Actin filament reorganizationIEA ISSbiological_process
GO:1900025Negative regulation of substrate adhesion-dependent cell spreadingIEA ISSbiological_process
GO:1900026Positive regulation of substrate adhesion-dependent cell spreadingIEA ISSbiological_process
GO:1901731Positive regulation of platelet aggregationIEA ISSbiological_process
GO:2001046Positive regulation of integrin-mediated signaling pathwayIEA ISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.38311944080.41937273280.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1243218204
GSE13712_SHEARDown-1.8492040988
GSE13712_STATICDown-0.8491338324
GSE19018Up0.0190321517
GSE19899_A1Up0.1836842268
GSE19899_A2Up0.2470409576
PubMed_21979375_A1Up0.5530545264
PubMed_21979375_A2Up0.0354847235
GSE35957Up0.1800637656
GSE36640Down-0.1010108168
GSE54402Up0.0965775952
GSE9593Up0.0282384792
GSE43922Up0.0159930442
GSE24585Down-0.1400755812
GSE37065Down-0.0275693153
GSE28863_A1Down-0.0909062183
GSE28863_A2Down-0.0193668771
GSE28863_A3Up0.4454382479
GSE28863_A4Up0.1163598584
GSE48662Up0.1501623191

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-1MIMAT0000416MIRT023523MicroarrayFunctional MTI (Weak)18668037
hsa-miR-93-3pMIMAT0004509MIRT038860CLASHFunctional MTI (Weak)23622248
hsa-miR-484MIMAT0002174MIRT042375CLASHFunctional MTI (Weak)23622248
hsa-miR-149-5pMIMAT0000450MIRT045524CLASHFunctional MTI (Weak)23622248
hsa-miR-23b-3pMIMAT0000418MIRT046337CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.