HCSGD entry for NRK
1. General information
| Official gene symbol | NRK |
|---|---|
| Entrez ID | 203447 |
| Gene full name | Nik related kinase |
| Other gene symbols | NESK |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004674 | Protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0004702 | Receptor signaling protein serine/threonine kinase activity | IBA | molecular_function |
| GO:0005083 | Small GTPase regulator activity | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005737 | Cytoplasm | IBA | cellular_component |
| GO:0007165 | Signal transduction | IBA | biological_process |
| GO:0007256 | Activation of JNKK activity | IEA | biological_process |
| GO:0007567 | Parturition | IEA | biological_process |
| GO:0008285 | Negative regulation of cell proliferation | IEA | biological_process |
| GO:0016301 | Kinase activity | IEA | molecular_function |
| GO:0023014 | Signal transduction by phosphorylation | IBA | biological_process |
| GO:0035556 | Intracellular signal transduction | IBA | biological_process |
| GO:0060721 | Regulation of spongiotrophoblast cell proliferation | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0026720527 | 0.1978669503 | 0.1391505929 | 0.8601435178 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0626295525 |
| GSE13712_SHEAR | Down | -1.0201836609 |
| GSE13712_STATIC | Down | -1.0616658874 |
| GSE19018 | Down | -1.0319619685 |
| GSE19899_A1 | Up | 0.6513163566 |
| GSE19899_A2 | Up | 1.8752600915 |
| PubMed_21979375_A1 | Up | 2.2114719093 |
| PubMed_21979375_A2 | Up | 0.9401840557 |
| GSE35957 | Up | 0.0170520547 |
| GSE36640 | Down | -2.6132804967 |
| GSE54402 | Up | 1.4626344150 |
| GSE9593 | Up | 0.0104267362 |
| GSE43922 | Up | 1.3895248211 |
| GSE24585 | Up | 0.1004341626 |
| GSE37065 | Down | -0.0595041992 |
| GSE28863_A1 | Down | -0.1521377123 |
| GSE28863_A2 | Up | 2.3001853989 |
| GSE28863_A3 | Up | 0.9150584272 |
| GSE28863_A4 | Up | 0.0094567877 |
| GSE48662 | Down | -0.0070263396 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018046 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
