HCSGD entry for EPAS1

1. General information

Official gene symbolEPAS1
Entrez ID2034
Gene full nameendothelial PAS domain protein 1
Other gene symbolsECYT4 HIF2A HLF MOP2 PASD2 bHLHe73
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionIEAmolecular_function
GO:0001525AngiogenesisIEAbiological_process
GO:0001666Response to hypoxiaIDAbiological_process
GO:0001892Embryonic placenta developmentIEAbiological_process
GO:0001974Blood vessel remodelingIEAbiological_process
GO:0002027Regulation of heart rateIEAbiological_process
GO:0003677DNA bindingIEA IGImolecular_function
GO:0004871Signal transducer activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005667Transcription factor complexIDA IEA IPIcellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006366Transcription from RNA polymerase II promoterTASbiological_process
GO:0007005Mitochondrion organizationIEAbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007601Visual perceptionIEAbiological_process
GO:0008134Transcription factor bindingIEA IPImolecular_function
GO:0030218Erythrocyte differentiationIEAbiological_process
GO:0030324Lung developmentIEAbiological_process
GO:0035035Histone acetyltransferase bindingIPImolecular_function
GO:0042415Norepinephrine metabolic processIEAbiological_process
GO:0043129Surfactant homeostasisIEAbiological_process
GO:0043565Sequence-specific DNA bindingIDAmolecular_function
GO:0043619Regulation of transcription from RNA polymerase II promoter in response to oxidative stressIEAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDA IGIbiological_process
GO:0046982Protein heterodimerization activityIEA IPImolecular_function
GO:0048469Cell maturationIEAbiological_process
GO:0048625Myoblast fate commitmentIEA ISSbiological_process
GO:0061418Regulation of transcription from RNA polymerase II promoter in response to hypoxiaTASbiological_process
GO:0071456Cellular response to hypoxiaIDA TASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.73048024010.00790376130.99999024730.1775516624

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1874623686
GSE13712_SHEARDown-0.4531901709
GSE13712_STATICDown-0.5750247908
GSE19018Down-0.0669151651
GSE19899_A1Down-1.2762813618
GSE19899_A2Down-0.8662250438
PubMed_21979375_A1Down-1.3663398735
PubMed_21979375_A2Down-0.5701915489
GSE35957Up0.1709780148
GSE36640Up0.6665946027
GSE54402Down-1.3875417878
GSE9593Up0.6877187785
GSE43922Down-0.8782260801
GSE24585Down-0.1562140026
GSE37065Up0.0189256870
GSE28863_A1Up0.2600786444
GSE28863_A2Up0.6784534598
GSE28863_A3Down-0.2149743204
GSE28863_A4Down-0.2229943934
GSE48662Up0.2247760026

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-185-5pMIMAT0000455MIRT006962Luciferase reporter assay//qRT-PCRFunctional MTI22745131
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26057707Expression of the hypoxia inducible factors HIF1-alpha (HIF1A gene) and HIF2-alpha (EPAS1 gene) and/or hypoxia-regulated pathways has been shown to promote the undifferentiated phenotype of NBL cells
26057707Our hypothesis is that HIF1A and EPAS1 expression represent one of the mechanisms responsible for the lack of responsiveness of NBL to differentiation therapy
26057707Clinically, high levels of HIF1A and EPAS1 expression were associated with inferior survival in two NBL microarray datasets, and patient subgroups with lower expression of HIF1A and EPAS1 showed significant enrichment of pathways related to neuronal differentiation
26057707In NBL cell lines, the combination of all-trans retinoic acid (ATRA) with HIF1A or EPAS1 silencing led to an acquired glial-cell phenotype and enhanced expression of glial-cell differentiation markers
26057707Furthermore, HIF1A or EPAS1 silencing might promote cell senescence independent of ATRA treatment
20206201It is becoming apparent that hypoxia causes the progressive elevation in mitochondrial ROS production (chronic ROS) which over time leads to stabilization of cells via increased HIF-2alpha expression, enabling cells to survive with sustained levels of elevated ROS
20206201In cells under hypoxia and/or low glucose, DNA mismatch repair processes are repressed by HIF-2alpha and they continually accumulate mitochondrial ROS-induced oxidative DNA damage and increasing numbers of mutations driving the malignant transformation process
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