HCSGD entry for TUBB
1. General information
| Official gene symbol | TUBB |
|---|---|
| Entrez ID | 203068 |
| Gene full name | tubulin, beta class I |
| Other gene symbols | M40 OK/SW-cl.56 TUBB1 TUBB5 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000086 | G2/M transition of mitotic cell cycle | TAS | biological_process |
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0003924 | GTPase activity | IEA | molecular_function |
| GO:0005198 | Structural molecule activity | TAS | molecular_function |
| GO:0005200 | Structural constituent of cytoskeleton | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005525 | GTP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005641 | Nuclear envelope lumen | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005856 | Cytoskeleton | TAS | cellular_component |
| GO:0005874 | Microtubule | IDA IEA TAS | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0006928 | Cellular component movement | TAS | biological_process |
| GO:0007017 | Microtubule-based process | IEA TAS | biological_process |
| GO:0009987 | Cellular process | IDA | biological_process |
| GO:0015630 | Microtubule cytoskeleton | IDA | cellular_component |
| GO:0019904 | Protein domain specific binding | IEA | molecular_function |
| GO:0030705 | Cytoskeleton-dependent intracellular transport | TAS | biological_process |
| GO:0032403 | Protein complex binding | IEA | molecular_function |
| GO:0032794 | GTPase activating protein binding | IEA | molecular_function |
| GO:0042267 | Natural killer cell mediated cytotoxicity | NAS | biological_process |
| GO:0042288 | MHC class I protein binding | IDA | molecular_function |
| GO:0044297 | Cell body | IDA | cellular_component |
| GO:0051225 | Spindle assembly | IEA | biological_process |
| GO:0051258 | Protein polymerization | IEA | biological_process |
| GO:0051301 | Cell division | TAS | biological_process |
| GO:0070062 | Extracellular vesicular exosome | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9952016451 | 0.0054221230 | 0.9999902473 | 0.1492842050 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2923446605 |
| GSE13712_SHEAR | Down | -0.2807393160 |
| GSE13712_STATIC | Down | -0.2425624588 |
| GSE19018 | Down | -0.0347551098 |
| GSE19899_A1 | Down | -0.8607952804 |
| GSE19899_A2 | Down | -0.7815106253 |
| PubMed_21979375_A1 | Down | -0.2258679892 |
| PubMed_21979375_A2 | Down | -0.9699249942 |
| GSE35957 | Down | -0.8054865346 |
| GSE36640 | Down | -0.8105898163 |
| GSE54402 | Down | -0.0724031609 |
| GSE9593 | Down | -0.3350329434 |
| GSE43922 | Down | -0.2075403491 |
| GSE24585 | Down | -0.1741406538 |
| GSE37065 | Down | -0.3370949501 |
| GSE28863_A1 | Down | -0.0272406384 |
| GSE28863_A2 | Down | -0.1099053790 |
| GSE28863_A3 | Up | 0.1189120990 |
| GSE28863_A4 | Down | -0.0525156411 |
| GSE48662 | Down | -0.8699978666 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Vinorelbine | DB00361 | APRD00101 |
| Vincristine | DB00541 | APRD00495 |
| Vinblastine | DB00570 | APRD00708 |
| Podofilox | DB01179 | APRD01189 | DB08417 |
| Colchicine | DB01394 | - |
| Epothilone D | DB01873 | EXPT01350 |
| Epothilone B | DB03010 | EXPT01349 |
| CYT997 | DB05147 | - |
| CA4P | DB05284 | - |
| ZEN-012 | DB06042 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-16-5p | MIMAT0000069 | MIRT031467 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031467 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-1180-3p | MIMAT0005825 | MIRT035930 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320c | MIMAT0005793 | MIRT036174 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320b | MIMAT0005792 | MIRT036208 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-935 | MIMAT0004978 | MIRT036662 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-877-5p | MIMAT0004949 | MIRT037326 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-708-5p | MIMAT0004926 | MIRT037752 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-423-5p | MIMAT0004748 | MIRT038161 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-1-5p | MIMAT0004507 | MIRT038919 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040151 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-18a-3p | MIMAT0002891 | MIRT040807 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-505-3p | MIMAT0002876 | MIRT041042 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041196 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT041962 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-196b-5p | MIMAT0001080 | MIRT042686 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-3p | MIMAT0000762 | MIRT042825 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-5p | MIMAT0000761 | MIRT043153 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-330-3p | MIMAT0000751 | MIRT043834 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044678 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT045131 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-185-5p | MIMAT0000455 | MIRT045340 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-196a-5p | MIMAT0000226 | MIRT048255 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-107 | MIMAT0000104 | MIRT048296 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049404 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-25-3p | MIMAT0000081 | MIRT050270 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-20a-5p | MIMAT0000075 | MIRT050552 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT051953 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
