HCSGD entry for ENG

1. General information

Official gene symbolENG
Entrez ID2022
Gene full nameendoglin
Other gene symbolsEND HHT1 ORW1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0001300Chronological cell agingIEA IEPbiological_process
GO:0001569Patterning of blood vesselsIEA ISSbiological_process
GO:0001570VasculogenesisIEA IMPbiological_process
GO:0001666Response to hypoxiaIDAbiological_process
GO:0001934Positive regulation of protein phosphorylationIDA IEAbiological_process
GO:0001937Negative regulation of endothelial cell proliferationIMPbiological_process
GO:0001947Heart loopingIEA ISSbiological_process
GO:0003084Positive regulation of systemic arterial blood pressureIMPbiological_process
GO:0003273Cell migration involved in endocardial cushion formationIEAbiological_process
GO:0004888Transmembrane signaling receptor activityNASmolecular_function
GO:0005024Transforming growth factor beta-activated receptor activityIDAmolecular_function
GO:0005072Transforming growth factor beta receptor, cytoplasmic mediator activityIDAmolecular_function
GO:0005114Type II transforming growth factor beta receptor bindingIEA IPI ISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005534Galactose bindingIDAmolecular_function
GO:0005539Glycosaminoglycan bindingIDA ISSmolecular_function
GO:0005615Extracellular spaceIDAcellular_component
GO:0005634NucleusIDAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0006355Regulation of transcription, DNA-templatedIMPbiological_process
GO:0006468Protein phosphorylationIDAbiological_process
GO:0007155Cell adhesionIEAbiological_process
GO:0007179Transforming growth factor beta receptor signaling pathwayIDAbiological_process
GO:0008152Metabolic processIDAbiological_process
GO:0009897External side of plasma membraneIDAcellular_component
GO:0009986Cell surfaceIDA IEAcellular_component
GO:0010628Positive regulation of gene expressionIEAbiological_process
GO:0010862Positive regulation of pathway-restricted SMAD protein phosphorylationIDA IMPbiological_process
GO:0016310PhosphorylationIDAbiological_process
GO:0016477Cell migrationIMPbiological_process
GO:0017015Regulation of transforming growth factor beta receptor signaling pathwayIDA IEAbiological_process
GO:0022009Central nervous system vasculogenesisIMPbiological_process
GO:0022617Extracellular matrix disassemblyIMPbiological_process
GO:0030155Regulation of cell adhesionTASbiological_process
GO:0030336Negative regulation of cell migrationIDAbiological_process
GO:0030509BMP signaling pathwayTASbiological_process
GO:0030512Negative regulation of transforming growth factor beta receptor signaling pathwayTASbiological_process
GO:0030513Positive regulation of BMP signaling pathwayIDAbiological_process
GO:0031953Negative regulation of protein autophosphorylationIDAbiological_process
GO:0031960Response to corticosteroidIEAbiological_process
GO:0032967Positive regulation of collagen biosynthetic processIEAbiological_process
GO:0034713Type I transforming growth factor beta receptor bindingIPI ISSmolecular_function
GO:0035556Intracellular signal transductionIDAbiological_process
GO:0036273Response to statinIEAbiological_process
GO:0042060Wound healingIMPbiological_process
GO:0042127Regulation of cell proliferationTASbiological_process
GO:0042325Regulation of phosphorylationTASbiological_process
GO:0042803Protein homodimerization activityIEA IPImolecular_function
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0048185Activin bindingTASmolecular_function
GO:0048745Smooth muscle tissue developmentIEA ISSbiological_process
GO:0048844Artery morphogenesisIEA ISSbiological_process
GO:0048845Venous blood vessel morphogenesisIEA ISSbiological_process
GO:0048870Cell motilityIMPbiological_process
GO:0050431Transforming growth factor beta bindingIEA IPImolecular_function
GO:0051001Negative regulation of nitric-oxide synthase activityIMPbiological_process
GO:0060326Cell chemotaxisIMPbiological_process
GO:0060348Bone developmentIEAbiological_process
GO:0060394Negative regulation of pathway-restricted SMAD protein phosphorylationIMPbiological_process
GO:0070022Transforming growth factor beta receptor homodimeric complexICcellular_component
GO:0070278Extracellular matrix constituent secretionIEAbiological_process
GO:0070483Detection of hypoxiaIDAbiological_process
GO:0071260Cellular response to mechanical stimulusIEAbiological_process
GO:0071559Response to transforming growth factor betaIEAbiological_process
GO:0072563Endothelial microparticleIEAcellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00715679500.98006502410.22080925061.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0319092520
GSE13712_SHEARUp0.4194046883
GSE13712_STATICUp0.1494261639
GSE19018Up0.1853517898
GSE19899_A1Down-0.0313220810
GSE19899_A2Up0.5784070482
PubMed_21979375_A1Up0.1586422453
PubMed_21979375_A2Up0.8435747699
GSE35957Down-0.1280321703
GSE36640Up1.0487598082
GSE54402Up0.1512866747
GSE9593Up0.2929359136
GSE43922Up0.2432623157
GSE24585Up0.1061177160
GSE37065Down-0.0773934408
GSE28863_A1Up0.8898576674
GSE28863_A2Up0.4263443569
GSE28863_A3Up0.5442421459
GSE28863_A4Up0.0202503171
GSE48662Up0.7834408350

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-let-7b-5pMIMAT0000063MIRT032385ProteomicsFunctional MTI (Weak)18668040
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 13 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

27067789In this study of 126 patients, we investigated the association between Endoglin expression in GC peritoneum and the clinicopathological features
27067789The prognosis of patients was evaluated according to Endoglin and ID1 expression
27067789Endoglin and ID1 expression was evaluated by Western blot
27067789Our results showed that positive staining of Endoglin (38%) was associated with a higher TNM stage and higher incidence of GCPD (both P <
27067789Kaplan-Meier analysis showed that the patients who were Endoglin positive had a shorter survival time compared with Endoglin-negative patients (P =
27067789Using the HPMC and GCC adherence and invasion assay, we demonstrated that transforming growth factor beta 1 (TGF-beta)1-induced HPMC senescence was attenuated by silencing the Endoglin expression, which also prevented GCC attachment and invasion
27067789Our study indicated a positive correlation between Endoglin overexpression and GCPD
27067789Up-regulated Endoglin expression induced HPMC senescence via TGF-beta1 pathway
26196672CD105 levels varied (BMA13 87
25437179When compared with N-UC-MSCs, GDM-UC-MSCs showed decreased cell growth and earlier cellular senescence with accumulation of p16 and p53, even though they expressed similar levels of CD105, CD90, and CD73 MSC marker proteins
24777481Expression of endoglin isoforms in the myeloid lineage and their role during aging and macrophage polarization
24777481Endoglin plays a crucial role in pathophysiological processes such as hereditary hemorrhagic telangiectasia (HHT), preeclampsia and cancer
24777481Endoglin expression is upregulated during the monocyte-to-macrophage transition, but little is known about its regulation and function in these immune cells
24777481Two different alternatively spliced isoforms of endoglin have been reported, L-endoglin and S-endoglin
24777481Gene expression and functional studies suggested that there was a non-redundant role for each endoglin isoform in monocyte biology
241703705 cc of bone marrow was needed to predictably isolate aBMSCs, and, regardless of methodology for harvest, cell-surface marker expression of CD73, CD90, CD105, and Stro-1 was similar for aBMSCs, being 89
22470345Based on its senescence-dependent involvement in alternative splicing, we postulate that SRSF1 is a key marker of EC senescence, regulating the expression of alternative isoforms of target genes such as endoglin (ENG), vascular endothelial growth factor A (VEGFA), tissue factor (T3), or lamin A (LMNA) that integrate in a common molecular senescence program
22242193Long term treatment did not induce lineage commitment in terms of osteogenic pathways but maintained their clonogenic capacity, their surface marker characteristics (expression of CD73, CD90, CD105) and their multipotency to develop towards the chondrogenic, adipogenic and osteogenic pathways
20225285The expressions of CD166, CD49a, and CD106 decreased, whereas those of CD10, CD29, CD44, CD73, CD90, and CD105 showed no significant change
20132052FACS analysis confirmed expression of the stem cell markers CD44, CD90, CD105, and CD166, but negative expression of CD34 and CD45 ruling out a hematopoietic or fibrocyte origin for these progenitors
18974388Here, we have analyzed the expression, during EC senescence, of 2 different isoforms (L, long; S, short) of endoglin, an auxiliary transforming growth factor (TGF)-beta receptor involved in vascular remodeling and angiogenesis
18974388As evidenced by RT-PCR, the S/L ratio of endoglin isoforms was increased during senescence of human ECs in vitro, as well as during aging of mice in vascularized tissues
17371154Flow cytometric analysis indicated a strong need to investigate for novel cell-surface characteristic markers of BMSCs because there was no obvious difference in the expression of the selected characteristic BMSC cell surface markers CD29, CD44, CD90, CD105, and CD166 between fast-growing and slow-growing clones
16507351Effect of aging on the pluripotential capacity of human CD105+ mesenchymal stem cells
16507351AIM: To compare the differentiation capacity of human CD105(+) MSCs obtained from young and elderly donors
16507351Adipogenic and osteogenic potential of CD105(+) MSCs was demonstrated
16507351CONCLUSION: Age does not influence the adipogenic and myogenic differentiation potential of human CD105(+) MSCs
16229018There was a high expression of CD90, CD29, CD44 and CD105 and variable and moderate expression of CD166 and CD106 at the start of MSC culture and at each passage during expansion
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