HCSGD entry for CTTN
1. General information
| Official gene symbol | CTTN |
|---|---|
| Entrez ID | 2017 |
| Gene full name | cortactin |
| Other gene symbols | EMS1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001726 | Ruffle | IEA ISS | cellular_component |
| GO:0003779 | Actin binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IDA ISS | cellular_component |
| GO:0005856 | Cytoskeleton | IEA | cellular_component |
| GO:0005938 | Cell cortex | IEA ISS | cellular_component |
| GO:0030027 | Lamellipodium | IDA IEA ISS | cellular_component |
| GO:0030041 | Actin filament polymerization | IEA | biological_process |
| GO:0043197 | Dendritic spine | IEA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0649120474 | 0.9392126211 | 0.5491152635 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.6177214323 |
| GSE13712_SHEAR | Up | 0.5089892181 |
| GSE13712_STATIC | Up | 0.1873816774 |
| GSE19018 | Down | -0.1155267652 |
| GSE19899_A1 | Up | 0.1982402848 |
| GSE19899_A2 | Up | 0.7301526954 |
| PubMed_21979375_A1 | Up | 0.4077600161 |
| PubMed_21979375_A2 | Up | 0.2236181322 |
| GSE35957 | Up | 0.0291680651 |
| GSE36640 | Up | 0.4408257271 |
| GSE54402 | Up | 0.3201337570 |
| GSE9593 | Up | 0.2568177538 |
| GSE43922 | Down | -0.0537679238 |
| GSE24585 | Down | -0.1613680813 |
| GSE37065 | Down | -0.2338593979 |
| GSE28863_A1 | Down | -0.0224627690 |
| GSE28863_A2 | Up | 0.3616907756 |
| GSE28863_A3 | Down | -0.2361843825 |
| GSE28863_A4 | Up | 0.0908366862 |
| GSE48662 | Down | -0.0668332543 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-340-5p | MIMAT0004692 | MIRT019566 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-1 | MIMAT0000416 | MIRT023872 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-1 | MIMAT0000416 | MIRT023872 | Proteomics;Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025473 | Proteomics | Functional MTI (Weak) | 21566225 |
| hsa-miR-185-5p | MIMAT0000455 | MIRT045376 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049499 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 8707855 | However, the tyrosine phosphorylation of FGFR-1 substrates, Src and cortactin, is impaired in senescent HUVEC, and only the presenescent cell populations exhibit a FGF-1-dependent Src tyrosine kinase activity |
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