HCSGD entry for EMD
1. General information
| Official gene symbol | EMD |
|---|---|
| Entrez ID | 2010 |
| Gene full name | emerin |
| Other gene symbols | EDMD LEMD5 STA |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0003779 | Actin binding | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005635 | Nuclear envelope | IDA TAS | cellular_component |
| GO:0005637 | Nuclear inner membrane | NAS | cellular_component |
| GO:0005640 | Nuclear outer membrane | IDA | cellular_component |
| GO:0005783 | Endoplasmic reticulum | IDA | cellular_component |
| GO:0005874 | Microtubule | IEA | cellular_component |
| GO:0006936 | Muscle contraction | TAS | biological_process |
| GO:0007077 | Mitotic nuclear envelope disassembly | TAS | biological_process |
| GO:0007084 | Mitotic nuclear envelope reassembly | TAS | biological_process |
| GO:0007517 | Muscle organ development | TAS | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0031965 | Nuclear membrane | IDA | cellular_component |
| GO:0035414 | Negative regulation of catenin import into nucleus | IMP | biological_process |
| GO:0035914 | Skeletal muscle cell differentiation | IEA | biological_process |
| GO:0046827 | Positive regulation of protein export from nucleus | IMP | biological_process |
| GO:0048147 | Negative regulation of fibroblast proliferation | IMP | biological_process |
| GO:0048487 | Beta-tubulin binding | IDA | molecular_function |
| GO:0060828 | Regulation of canonical Wnt signaling pathway | IMP | biological_process |
| GO:0071363 | Cellular response to growth factor stimulus | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9907787318 | 0.0070673455 | 0.9999902473 | 0.1677271827 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3815113184 |
| GSE13712_SHEAR | Down | -0.6934873074 |
| GSE13712_STATIC | Down | -0.1906425438 |
| GSE19018 | Down | -0.0706754598 |
| GSE19899_A1 | Down | -0.8177651430 |
| GSE19899_A2 | Down | -0.0628717564 |
| PubMed_21979375_A1 | Up | 0.2172195619 |
| PubMed_21979375_A2 | Down | -0.8396992734 |
| GSE35957 | Down | -0.2369515899 |
| GSE36640 | Down | -0.4407624706 |
| GSE54402 | Down | -0.0042325372 |
| GSE9593 | Down | -0.1598887287 |
| GSE43922 | Down | -0.1860009637 |
| GSE24585 | Down | -0.5259087350 |
| GSE37065 | Down | -0.4218455765 |
| GSE28863_A1 | Up | 0.0312802259 |
| GSE28863_A2 | Down | -0.8232199374 |
| GSE28863_A3 | Down | -0.0421999142 |
| GSE28863_A4 | Down | -0.0716081284 |
| GSE48662 | Up | 0.0424348655 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT022307 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-1 | MIMAT0000416 | MIRT023624 | Proteomics;Microarray | Non-Functional MTI (Weak) | 18668037 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040236 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT041790 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-125b-5p | MIMAT0000423 | MIRT046034 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049830 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-25-3p | MIMAT0000081 | MIRT050333 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27268410 | LARGE SCALE DATA: GEO accession number: GSE81579 STUDY FUNDING AND COMPETING INTERESTS: Funded in part by EMD Serono Grant for Fertility Innovation (GFI) |
| 19589617 | The organization of both lamin A/C and its inner nuclear membrane partner emerin are altered, eventually showing a honeycomb pattern upon immunofluorescence microscopy |
| 17274801 | A number of diseases associated with specific tissue degeneration and premature aging have mutations in the nuclear envelope proteins A-type lamins or emerin |
| 17274801 | Due to various hypothetical roles of nuclear envelope proteins in genome function we investigated whether alterations to normal genomic behaviour are apparent in cells with mutations in A-type lamins and emerin |
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