HCSGD entry for ELK1

1. General information

Official gene symbolELK1
Entrez ID2002
Gene full nameELK1, member of ETS oncogene family
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0002756MyD88-independent toll-like receptor signaling pathwayTASbiological_process
GO:0003700Sequence-specific DNA binding transcription factor activityIDA IEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIC IDAcellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0034134Toll-like receptor 2 signaling pathwayTASbiological_process
GO:0034138Toll-like receptor 3 signaling pathwayTASbiological_process
GO:0034142Toll-like receptor 4 signaling pathwayTASbiological_process
GO:0034146Toll-like receptor 5 signaling pathwayTASbiological_process
GO:0034162Toll-like receptor 9 signaling pathwayTASbiological_process
GO:0034166Toll-like receptor 10 signaling pathwayTASbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0038123Toll-like receptor TLR1:TLR2 signaling pathwayTASbiological_process
GO:0038124Toll-like receptor TLR6:TLR2 signaling pathwayTASbiological_process
GO:0043565Sequence-specific DNA bindingIEAmolecular_function
GO:0045087Innate immune responseTASbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDA IEA IMPbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0051403Stress-activated MAPK cascadeTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.39978563120.88826972760.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0959888545
GSE13712_SHEARDown-0.1535697172
GSE13712_STATICDown-0.3006122409
GSE19018Up0.1573849516
GSE19899_A1Down-0.0021029105
GSE19899_A2Up0.1561491949
PubMed_21979375_A1Up0.1473362835
PubMed_21979375_A2Up0.0877330170
GSE35957Down-0.1465754533
GSE36640Down-0.2020121076
GSE54402Up0.2777954497
GSE9593Up0.2528808204
GSE43922Up0.1592827476
GSE24585Up0.1975003604
GSE37065Down-0.1750827634
GSE28863_A1Down-0.0778207523
GSE28863_A2Up0.0310850186
GSE28863_A3Up0.1735835900
GSE28863_A4Down-0.0048443566
GSE48662Up0.1180850768

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-186-5pMIMAT0000456MIRT021088SequencingFunctional MTI (Weak)20371350
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25945449RESULTS: Different transcriptional profiles were observed in young, pre-senescent and senescent HDFs, in which cellular aging increased AKT, FOXO3, CDKN1A and RSK1 mRNA expression level, but decreased ELK1, FOS and SIRT1 mRNA expression level
25945449The three down-regulated mRNA in cellular aging, ELK1, FOS and SIRT1, were increased with tocotrienol-rich fraction treatment
19696787Instead, upregulation of miR-34a is mediated by the ETS family transcription factor, ELK1
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