HCSGD entry for ELANE
1. General information
| Official gene symbol | ELANE |
|---|---|
| Entrez ID | 1991 |
| Gene full name | elastase, neutrophil expressed |
| Other gene symbols | ELA2 GE HLE HNE NE PMN-E SCN1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001878 | Response to yeast | IEA | biological_process |
| GO:0002020 | Protease binding | IPI | molecular_function |
| GO:0002438 | Acute inflammatory response to antigenic stimulus | IEA | biological_process |
| GO:0004175 | Endopeptidase activity | IDA | molecular_function |
| GO:0004252 | Serine-type endopeptidase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | NAS TAS | cellular_component |
| GO:0006508 | Proteolysis | IDA | biological_process |
| GO:0006874 | Cellular calcium ion homeostasis | NAS | biological_process |
| GO:0006909 | Phagocytosis | IEA | biological_process |
| GO:0008201 | Heparin binding | IDA | molecular_function |
| GO:0008233 | Peptidase activity | IDA | molecular_function |
| GO:0009411 | Response to UV | IDA | biological_process |
| GO:0009986 | Cell surface | IDA | cellular_component |
| GO:0019955 | Cytokine binding | IPI | molecular_function |
| GO:0022617 | Extracellular matrix disassembly | TAS | biological_process |
| GO:0030141 | Secretory granule | IDA | cellular_component |
| GO:0030163 | Protein catabolic process | NAS | biological_process |
| GO:0030198 | Extracellular matrix organization | TAS | biological_process |
| GO:0030574 | Collagen catabolic process | TAS | biological_process |
| GO:0032496 | Response to lipopolysaccharide | IEA | biological_process |
| GO:0042742 | Defense response to bacterium | IDA | biological_process |
| GO:0043406 | Positive regulation of MAP kinase activity | NAS | biological_process |
| GO:0044130 | Negative regulation of growth of symbiont in host | IEA | biological_process |
| GO:0045079 | Negative regulation of chemokine biosynthetic process | IDA | biological_process |
| GO:0045415 | Negative regulation of interleukin-8 biosynthetic process | IDA | biological_process |
| GO:0045416 | Positive regulation of interleukin-8 biosynthetic process | IDA | biological_process |
| GO:0048661 | Positive regulation of smooth muscle cell proliferation | IDA | biological_process |
| GO:0050728 | Negative regulation of inflammatory response | NAS | biological_process |
| GO:0050778 | Positive regulation of immune response | IEA | biological_process |
| GO:0050900 | Leukocyte migration | IEA | biological_process |
| GO:0050922 | Negative regulation of chemotaxis | NAS | biological_process |
| GO:0070947 | Neutrophil mediated killing of fungus | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1963257627 | 0.8618853235 | 0.8576747552 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0481106200 |
| GSE13712_SHEAR | Up | 0.0965896386 |
| GSE13712_STATIC | Up | 0.0746813712 |
| GSE19018 | Up | 0.0147013605 |
| GSE19899_A1 | Down | -0.1998106935 |
| GSE19899_A2 | Up | 0.0016025403 |
| PubMed_21979375_A1 | Down | -0.1779551761 |
| PubMed_21979375_A2 | Down | -0.0956688078 |
| GSE35957 | Up | 0.2453610760 |
| GSE36640 | Up | 0.0166418446 |
| GSE54402 | Up | 0.0187850665 |
| GSE9593 | Down | -0.3704069688 |
| GSE43922 | Up | 0.1756982749 |
| GSE24585 | Up | 0.3693542751 |
| GSE37065 | Down | -0.1357057890 |
| GSE28863_A1 | Up | 0.1985474485 |
| GSE28863_A2 | Up | 0.1163507093 |
| GSE28863_A3 | Up | 0.5897851267 |
| GSE28863_A4 | Up | 0.1283661519 |
| GSE48662 | Up | 0.2146923792 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| Pegfilgrastim | DB00019 | BTD00094 | BIOD00094 |
| Filgrastim | DB00099 | BTD00072 | BIOD00072 |
| Mdl 101,146 | DB02341 | EXPT02880 |
| ONO-6818 | DB03925 | EXPT00279 |
| Elafin | DB05161 | - |
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 5 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23339189 | In addition, human HCC cell lines (Hep3B, HepG2, HuH7, HLE, HLF, HepKK1, skHep1) were screened for the expression of the sirtuin family members and only SIRT1 was consistently overexpressed compared with normal hepatocytes |
| 23316069 | Cystic Fibrosis (CF) is a chronic lung disease characterized by chronic neutrophilic airway inflammation and increased levels of neutrophil elastase (NE) in the airways |
| 20102351 | Oxidized proteins as well as proteins modified by the lipid peroxidation product 4-hydroxy-2-nonenal (HNE) and by glycation (AGE) have been shown to accumulate with aging in vivo and during replicative senescence in vitro |
| 20102351 | To better understand the mechanisms by which these damaged proteins build up and potentially affect cellular function during replicative senescence of WI-38 fibroblasts, proteins targeted by these modifications have been identified using a bidimensional gel electrophoresis-based proteomic approach coupled with immunodetection of HNE-, AGE-modified and carbonylated proteins |
| 18503423 | Several experiments have been carried out, with the aim being to be as close as possible to conditions in vivo and more particularly to demonstrate their 'lipid peroxidase-like' activity or their efficiency against 'toxic aldehydes': HNE, from the oxidation of phospholipids [1], and glucosone, from that of sugars |
| 9033259 | Lipid peroxidation produces several cytotoxic aldehydes, one of the most potent being 4-hydroxy-2-nonenal (HNE) |
| 9033259 | We have shown previously that HNE is a potent neurotoxin that covalently modifies and cross-links neuronal cytoskeletal protein in neuroglial cultures, suggesting that HNE may contribute to the pathogenesis of AD |
| 9033259 | We tested the hypothesis that HNE may yield a particular type of protein modification, pyrrole adduction, and that this may contribute to the pathogenesis of AD |
| 9033259 | Our data demonstrated that HNE formed pyrrole adducts with protein |
| 9033259 | Polyclonal antiserum was raised that specifically recognized HNE pyrrole adducts, and immunohistochemical analysis was performed on hippocampus and temporal cortex of 10 patients with histologically verified AD |
| 9033259 | These data suggest that differences in neuronal protein modification by HNE may account in part for the APOE-associated stratification of risk for late-onset AD |
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