HCSGD entry for EIF5A
1. General information
| Official gene symbol | EIF5A |
|---|---|
| Entrez ID | 1984 |
| Gene full name | eukaryotic translation initiation factor 5A |
| Other gene symbols | EIF-5A EIF5A1 eIF5AI |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003723 | RNA binding | IDA | molecular_function |
| GO:0003746 | Translation elongation factor activity | IEA ISS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005642 | Annulate lamellae | IDA | cellular_component |
| GO:0005643 | Nuclear pore | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005789 | Endoplasmic reticulum membrane | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006406 | MRNA export from nucleus | IMP | biological_process |
| GO:0006452 | Translational frameshifting | IEA | biological_process |
| GO:0006611 | Protein export from nucleus | IMP | biological_process |
| GO:0006913 | Nucleocytoplasmic transport | IDA IMP | biological_process |
| GO:0006915 | Apoptotic process | IDA | biological_process |
| GO:0008284 | Positive regulation of cell proliferation | IGI | biological_process |
| GO:0008612 | Peptidyl-lysine modification to hypusine | IEA TAS | biological_process |
| GO:0017070 | U6 snRNA binding | IDA | molecular_function |
| GO:0043022 | Ribosome binding | IEA | molecular_function |
| GO:0043687 | Post-translational protein modification | TAS | biological_process |
| GO:0044267 | Cellular protein metabolic process | TAS | biological_process |
| GO:0045901 | Positive regulation of translational elongation | IEA ISS | biological_process |
| GO:0045905 | Positive regulation of translational termination | IEA | biological_process |
| GO:0047485 | Protein N-terminus binding | IPI | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0345557920 | 0.7861601345 | 0.4261199164 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0495888354 |
| GSE13712_SHEAR | Up | 2.1380911182 |
| GSE13712_STATIC | Up | 1.8855304432 |
| GSE19018 | Up | 0.0030608711 |
| GSE19899_A1 | Down | -0.0431810762 |
| GSE19899_A2 | Up | 0.3855926532 |
| PubMed_21979375_A1 | Up | 0.3180587312 |
| PubMed_21979375_A2 | Down | -0.1039551899 |
| GSE35957 | Up | 0.4431153434 |
| GSE36640 | Down | -0.4788732111 |
| GSE54402 | Up | 0.4151959956 |
| GSE9593 | Up | 0.1964597327 |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Down | -0.1141217436 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-877-5p | MIMAT0004949 | MIRT037297 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-296-3p | MIMAT0004679 | MIRT038418 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-769-5p | MIMAT0003886 | MIRT039182 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-423-3p | MIMAT0001340 | MIRT042623 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-181b-5p | MIMAT0000257 | MIRT047232 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-100-5p | MIMAT0000098 | MIRT048525 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-99a-5p | MIMAT0000097 | MIRT048616 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-25-3p | MIMAT0000081 | MIRT050318 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22370639 | The tumor-suppressive effect of ZNF331 is mediated at least by downregulation of genes involved in cell growth promotion (DSTN, EIF5A, GARS, DDX5, STAM, UQCRFS1 and SET) and migration/invasion (DSTN and ACTR3), and upregulation of genome-stability gene (SSBP1) and cellular senescence gene (PNPT1) |
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