HCSGD entry for EIF4E
1. General information
| Official gene symbol | EIF4E |
|---|---|
| Entrez ID | 1977 |
| Gene full name | eukaryotic translation initiation factor 4E |
| Other gene symbols | AUTS19 CBP EIF4E1 EIF4EL1 EIF4F |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000082 | G1/S transition of mitotic cell cycle | IMP | biological_process |
| GO:0000288 | Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | TAS | biological_process |
| GO:0000289 | Nuclear-transcribed mRNA poly(A) tail shortening | TAS | biological_process |
| GO:0000339 | RNA cap binding | TAS | molecular_function |
| GO:0000932 | Cytoplasmic mRNA processing body | IDA | cellular_component |
| GO:0003743 | Translation initiation factor activity | IDA IEA ISS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005845 | MRNA cap binding complex | IDA IEA | cellular_component |
| GO:0006406 | MRNA export from nucleus | TAS | biological_process |
| GO:0006412 | Translation | TAS | biological_process |
| GO:0006413 | Translational initiation | TAS | biological_process |
| GO:0006417 | Regulation of translation | IDA | biological_process |
| GO:0008286 | Insulin receptor signaling pathway | TAS | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0010494 | Cytoplasmic stress granule | IDA | cellular_component |
| GO:0016032 | Viral process | IEA | biological_process |
| GO:0016070 | RNA metabolic process | TAS | biological_process |
| GO:0016071 | MRNA metabolic process | TAS | biological_process |
| GO:0016281 | Eukaryotic translation initiation factor 4F complex | IDA IEA | cellular_component |
| GO:0016442 | RISC complex | IDA | cellular_component |
| GO:0019221 | Cytokine-mediated signaling pathway | TAS | biological_process |
| GO:0030324 | Lung development | IEA | biological_process |
| GO:0031370 | Eukaryotic initiation factor 4G binding | IEA | molecular_function |
| GO:0033391 | Chromatoid body | IEA | cellular_component |
| GO:0044267 | Cellular protein metabolic process | TAS | biological_process |
| GO:0045931 | Positive regulation of mitotic cell cycle | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2236925953 | 0.6819786216 | 0.9040289793 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0248626512 |
| GSE13712_SHEAR | Up | 0.3521650138 |
| GSE13712_STATIC | Up | 0.0798683508 |
| GSE19018 | Down | -0.3338664453 |
| GSE19899_A1 | Up | 0.4393469436 |
| GSE19899_A2 | Up | 0.1816545925 |
| PubMed_21979375_A1 | Up | 0.6173500613 |
| PubMed_21979375_A2 | Up | 0.1532794884 |
| GSE35957 | Up | 0.0486802690 |
| GSE36640 | Down | -0.0918852825 |
| GSE54402 | Up | 0.1837406617 |
| GSE9593 | Down | -0.3345340006 |
| GSE43922 | Up | 0.3384513510 |
| GSE24585 | Up | 0.1397916084 |
| GSE37065 | Up | 0.0462179003 |
| GSE28863_A1 | Up | 0.0916892915 |
| GSE28863_A2 | Up | 0.0352505504 |
| GSE28863_A3 | Down | -0.3841153112 |
| GSE28863_A4 | Down | -0.0906854049 |
| GSE48662 | Down | -0.3459347996 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| 7-Methyl-Gpppa | DB01649 | EXPT01652 |
| 7n-Methyl-8-Hydroguanosine-5'-Diphosphate | DB01960 | EXPT02090 | EXPT02143 |
| 7-Methyl-Guanosine-5'-Triphosphate | DB02716 | EXPT02167 |
| LY2275796 | DB05165 | - |
| 2,2,5,5-TETRAMETHYL-3-(SULFANYLMETHYL)-2,5-DIHYDRO-1H-PYRROL-1-OL | DB08217 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-16-5p | MIMAT0000069 | MIRT001469 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-141-3p | MIMAT0000432 | MIRT005479 | Luciferase reporter assay//Northern blot//qRT-PCR//Western blot | Functional MTI | 21238947 |
| hsa-miR-145-5p | MIMAT0000437 | MIRT005878 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 21092188 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT022728 | Proteomics;Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-1 | MIMAT0000416 | MIRT023809 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-7-5p | MIMAT0000252 | MIRT025789 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-505-5p | MIMAT0004776 | MIRT037944 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-769-5p | MIMAT0003886 | MIRT039192 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
