HCSGD entry for EIF4A2
1. General information
| Official gene symbol | EIF4A2 |
|---|---|
| Entrez ID | 1974 |
| Gene full name | eukaryotic translation initiation factor 4A2 |
| Other gene symbols | BM-010 DDX2B EIF4A EIF4F eIF-4A-II eIF4A-II |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000288 | Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | TAS | biological_process |
| GO:0000289 | Nuclear-transcribed mRNA poly(A) tail shortening | TAS | biological_process |
| GO:0003676 | Nucleic acid binding | IEA | molecular_function |
| GO:0003743 | Translation initiation factor activity | IEA | molecular_function |
| GO:0004386 | Helicase activity | TAS | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006412 | Translation | TAS | biological_process |
| GO:0006413 | Translational initiation | TAS | biological_process |
| GO:0006446 | Regulation of translational initiation | TAS | biological_process |
| GO:0008026 | ATP-dependent helicase activity | IEA | molecular_function |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0016032 | Viral process | IEA | biological_process |
| GO:0016070 | RNA metabolic process | TAS | biological_process |
| GO:0016071 | MRNA metabolic process | TAS | biological_process |
| GO:0016281 | Eukaryotic translation initiation factor 4F complex | TAS | cellular_component |
| GO:0019221 | Cytokine-mediated signaling pathway | TAS | biological_process |
| GO:0044267 | Cellular protein metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4549316743 | 0.7299690969 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0794771406 |
| GSE13712_SHEAR | Down | -0.0293883817 |
| GSE13712_STATIC | Up | 0.0494372338 |
| GSE19018 | Down | -0.1684351866 |
| GSE19899_A1 | Up | 0.0747296032 |
| GSE19899_A2 | Up | 0.2928589308 |
| PubMed_21979375_A1 | Up | 0.0618561818 |
| PubMed_21979375_A2 | Up | 0.0770927158 |
| GSE35957 | Up | 0.0462989722 |
| GSE36640 | Down | -0.1804338058 |
| GSE54402 | Up | 0.2003255547 |
| GSE9593 | Up | 0.1037807753 |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | Up | 0.3316291778 |
| GSE28863_A2 | Down | -0.2452809160 |
| GSE28863_A3 | Down | -0.0625984880 |
| GSE28863_A4 | Up | 0.1348967754 |
| GSE48662 | Down | -0.0967813440 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-21-5p | MIMAT0000076 | MIRT005772 | Immunoblot//Immunohistochemistry//Luciferase reporter assay//Microarray//qRT-PCR//Western blot | Functional MTI | 21219636 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT032347 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-744-5p | MIMAT0004945 | MIRT037614 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-331-3p | MIMAT0000760 | MIRT043428 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
