HCSGD entry for EIF4A1

1. General information

Official gene symbolEIF4A1
Entrez ID1973
Gene full nameeukaryotic translation initiation factor 4A1
Other gene symbolsDDX2A EIF-4A EIF4A eIF-4A-I eIF4A-I
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000288Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decayTASbiological_process
GO:0000289Nuclear-transcribed mRNA poly(A) tail shorteningTASbiological_process
GO:0000339RNA cap bindingTASmolecular_function
GO:0003676Nucleic acid bindingIEAmolecular_function
GO:0003725Double-stranded RNA bindingIDAmolecular_function
GO:0003729MRNA bindingTASmolecular_function
GO:0003743Translation initiation factor activityIEAmolecular_function
GO:0004386Helicase activityIEA TASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005829CytosolTAScellular_component
GO:0006412TranslationTASbiological_process
GO:0006413Translational initiationTASbiological_process
GO:0008026ATP-dependent helicase activityIEAmolecular_function
GO:0008135Translation factor activity, nucleic acid bindingTASmolecular_function
GO:0010467Gene expressionTASbiological_process
GO:0016032Viral processIEAbiological_process
GO:0016070RNA metabolic processTASbiological_process
GO:0016071MRNA metabolic processTASbiological_process
GO:0016281Eukaryotic translation initiation factor 4F complexTAScellular_component
GO:0019221Cytokine-mediated signaling pathwayTASbiological_process
GO:0031100Organ regenerationIEAbiological_process
GO:0044267Cellular protein metabolic processTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.97495278290.16480303940.99999024730.7854030056

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954--
GSE13712_SHEAR--
GSE13712_STATIC--
GSE19018--
GSE19899_A1--
GSE19899_A2--
PubMed_21979375_A1--
PubMed_21979375_A2--
GSE35957--
GSE36640--
GSE54402--
GSE9593--
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1Up0.0006822061
GSE28863_A2Down-0.6999202398
GSE28863_A3Up0.1954913334
GSE28863_A4Up0.1033927459
GSE48662Down-0.3925852984

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-15b-5pMIMAT0000417MIRT004526Luciferase reporter assayFunctional MTI16609010
hsa-miR-155-5pMIMAT0000646MIRT020524ProteomicsFunctional MTI (Weak)18668040
hsa-miR-26b-5pMIMAT0000083MIRT028833MicroarrayFunctional MTI (Weak)19088304
hsa-let-7b-5pMIMAT0000063MIRT032222ProteomicsFunctional MTI (Weak)18668040
hsa-miR-935MIMAT0004978MIRT036660CLASHFunctional MTI (Weak)23622248
hsa-miR-744-5pMIMAT0004945MIRT037664CLASHFunctional MTI (Weak)23622248
hsa-miR-93-3pMIMAT0004509MIRT038829CLASHFunctional MTI (Weak)23622248
hsa-miR-769-3pMIMAT0003887MIRT039072CLASHFunctional MTI (Weak)23622248
hsa-miR-421MIMAT0003339MIRT039364CLASHFunctional MTI (Weak)23622248
hsa-miR-615-3pMIMAT0003283MIRT040186CLASHFunctional MTI (Weak)23622248
hsa-miR-484MIMAT0002174MIRT041969CLASHFunctional MTI (Weak)23622248
hsa-miR-378a-5pMIMAT0000731MIRT044001CLASHFunctional MTI (Weak)23622248
hsa-miR-361-5pMIMAT0000703MIRT044105CLASHFunctional MTI (Weak)23622248
hsa-miR-23b-3pMIMAT0000418MIRT046374CLASHFunctional MTI (Weak)23622248
hsa-let-7e-5pMIMAT0000066MIRT051467CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.