HCSGD entry for UBR1
1. General information
| Official gene symbol | UBR1 |
|---|---|
| Entrez ID | 197131 |
| Gene full name | ubiquitin protein ligase E3 component n-recognin 1 |
| Other gene symbols | JBS |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000151 | Ubiquitin ligase complex | IEA | cellular_component |
| GO:0000502 | Proteasome complex | IEA | cellular_component |
| GO:0004842 | Ubiquitin-protein ligase activity | IEA | molecular_function |
| GO:0005829 | Cytosol | IEA | cellular_component |
| GO:0006511 | Ubiquitin-dependent protein catabolic process | IEA | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0032007 | Negative regulation of TOR signaling | IMP | biological_process |
| GO:0070728 | Leucine binding | IDA | molecular_function |
| GO:0071233 | Cellular response to leucine | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0294139166 | 0.9140233122 | 0.3973587179 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0163137989 |
| GSE13712_SHEAR | Up | 0.3786044189 |
| GSE13712_STATIC | Up | 0.4741350416 |
| GSE19018 | Up | 0.0935452697 |
| GSE19899_A1 | Up | 0.1283771616 |
| GSE19899_A2 | Up | 0.1174368071 |
| PubMed_21979375_A1 | Down | -0.0210903352 |
| PubMed_21979375_A2 | Up | 0.7642856203 |
| GSE35957 | Up | 0.0792058855 |
| GSE36640 | Up | 0.2499505574 |
| GSE54402 | Up | 0.0568782838 |
| GSE9593 | Down | -0.1363391829 |
| GSE43922 | Down | -0.0101158983 |
| GSE24585 | Up | 0.3043133608 |
| GSE37065 | Up | 0.0050564159 |
| GSE28863_A1 | Up | 1.1165838657 |
| GSE28863_A2 | Up | 1.3007043283 |
| GSE28863_A3 | Down | -0.4257968775 |
| GSE28863_A4 | Up | 0.1185469913 |
| GSE48662 | Down | -0.4021856252 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-93-5p | MIMAT0000093 | MIRT028165 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041472 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049731 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-25-3p | MIMAT0000081 | MIRT050218 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
