HCSGD entry for EPHA2

1. General information

Official gene symbolEPHA2
Entrez ID1969
Gene full nameEPH receptor A2
Other gene symbolsARCC2 CTPA CTPP1 CTRCT6 ECK
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001501Skeletal system developmentIEAbiological_process
GO:0001525AngiogenesisIEAbiological_process
GO:0001570VasculogenesisIEAbiological_process
GO:0001649Osteoblast differentiationISSbiological_process
GO:0004714Transmembrane receptor protein tyrosine kinase activityIDAmolecular_function
GO:0005003Ephrin receptor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005886Plasma membraneIDAcellular_component
GO:0005887Integral component of plasma membraneIDAcellular_component
GO:0005925Focal adhesionIDAcellular_component
GO:0007155Cell adhesionIEAbiological_process
GO:0007275Multicellular organismal developmentTASbiological_process
GO:0008630Intrinsic apoptotic signaling pathway in response to DNA damageIDAbiological_process
GO:0010591Regulation of lamellipodium assemblyIMPbiological_process
GO:0014028Notochord formationIEAbiological_process
GO:0016032Viral processIEAbiological_process
GO:0018108Peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0021915Neural tube developmentIEAbiological_process
GO:0030182Neuron differentiationIEAbiological_process
GO:0030216Keratinocyte differentiationIMPbiological_process
GO:0030316Osteoclast differentiationISSbiological_process
GO:0031256Leading edge membraneIDAcellular_component
GO:0031258Lamellipodium membraneIEAcellular_component
GO:0032587Ruffle membraneIEAcellular_component
GO:0032863Activation of Rac GTPase activityIMPbiological_process
GO:0033598Mammary gland epithelial cell proliferationISSbiological_process
GO:0033628Regulation of cell adhesion mediated by integrinIDAbiological_process
GO:0036342Post-anal tail morphogenesisIEAbiological_process
GO:0043491Protein kinase B signalingIDAbiological_process
GO:0043535Regulation of blood vessel endothelial cell migrationISSbiological_process
GO:0045765Regulation of angiogenesisISSbiological_process
GO:0046849Bone remodelingISSbiological_process
GO:0048013Ephrin receptor signaling pathwayIDAbiological_process
GO:0048320Axial mesoderm formationIEAbiological_process
GO:0051898Negative regulation of protein kinase B signalingIDAbiological_process
GO:0060035Notochord cell developmentIEAbiological_process
GO:0060326Cell chemotaxisIMPbiological_process
GO:0060444Branching involved in mammary gland duct morphogenesisISSbiological_process
GO:0070309Lens fiber cell morphogenesisISSbiological_process
GO:0070372Regulation of ERK1 and ERK2 cascadeIMPbiological_process
GO:0070848Response to growth factorIMPbiological_process
GO:0090004Positive regulation of establishment of protein localization to plasma membraneIMPbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.01888626190.16354788190.33613847190.7815438998

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.5116231639
GSE13712_SHEARUp1.0398671688
GSE13712_STATICUp0.5027071773
GSE19018Down-0.5675522964
GSE19899_A1Up0.7998187217
GSE19899_A2Up1.1733222175
PubMed_21979375_A1Up1.0537749099
PubMed_21979375_A2Up1.4465121124
GSE35957Down-1.2594123986
GSE36640Up0.5198621903
GSE54402Up0.4331889099
GSE9593Down-0.7140681641
GSE43922Up0.6029509770
GSE24585Down-0.0850692084
GSE37065Down-0.3867015481
GSE28863_A1Down-0.5334804952
GSE28863_A2Down-0.2842754444
GSE28863_A3Down-0.0261883869
GSE28863_A4Up0.0389456472
GSE48662Up0.1115422746

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

DasatinibDB01254 -
Phosphoaminophosphonic Acid-Adenylate EsterDB04395 EXPT00524
RegorafenibDB08896 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT005508Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI21264258
hsa-miR-193b-3pMIMAT0002819MIRT016375MicroarrayFunctional MTI (Weak)20304954
hsa-miR-34a-5pMIMAT0000255MIRT025420ProteomicsFunctional MTI (Weak)21566225
hsa-miR-16-5pMIMAT0000069MIRT031603ProteomicsFunctional MTI (Weak)18668040
hsa-miR-940MIMAT0004983MIRT036589CLASHFunctional MTI (Weak)23622248
Entries Per Page
Displaying Page of
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24141256Age-associated defects in EphA2 signaling impair the migration of human cardiac progenitor cells
24141256In the young heart, signaling by the guidance receptor EphA2 in response to the ephrin A1 ligand promotes hCPC motility and improves cardiac recovery after infarction
24141256EphA2 expression was not decreased in old hCPCs; however, the elevated level of reactive oxygen species in aged cells induced post-translational modifications of the EphA2 protein
24141256EphA2 oxidation interfered with ephrin A1-stimulated receptor auto-phosphorylation, activation of Src family kinases, and caveolin-1-mediated internalization of the receptor
24141256Cellular aging altered the EphA2 endocytic route, affecting the maturation of EphA2-containing endosomes and causing premature signal termination
24141256Overexpression of functionally intact EphA2 in old hCPCs corrected the defects in endocytosis and downstream signaling, enhancing cell motility
24141256Importantly, EphA2 receptor function can be implemented for the selection of hCPCs with high therapeutic potential, a clinically relevant strategy that does not require genetic manipulation of stem cells
Entries Per Page
Displaying Page of