HCSGD entry for ADCY4

1. General information

Official gene symbolADCY4
Entrez ID196883
Gene full nameadenylate cyclase 4
Other gene symbolsAC4
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000166Nucleotide bindingIEAmolecular_function
GO:0004016Adenylate cyclase activityIEA ISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005622IntracellularIEAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0006112Energy reserve metabolic processTASbiological_process
GO:0006171CAMP biosynthetic processISSbiological_process
GO:0006833Water transportTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007188Adenylate cyclase-modulating G-protein coupled receptor signaling pathwayIEA ISSbiological_process
GO:0007189Adenylate cyclase-activating G-protein coupled receptor signaling pathwayTASbiological_process
GO:0007193Adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwayTASbiological_process
GO:0007202Activation of phospholipase C activityTASbiological_process
GO:0007268Synaptic transmissionTASbiological_process
GO:0008543Fibroblast growth factor receptor signaling pathwayTASbiological_process
GO:0009190Cyclic nucleotide biosynthetic processIEAbiological_process
GO:0016020MembraneISScellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0016849Phosphorus-oxygen lyase activityIEAmolecular_function
GO:0030425DendriteIEAcellular_component
GO:0034199Activation of protein kinase A activityTASbiological_process
GO:0035556Intracellular signal transductionIEAbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0055085Transmembrane transportTASbiological_process
GO:0071377Cellular response to glucagon stimulusTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.11031029600.45755152160.68764697291.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.2010332927
GSE13712_SHEARDown-0.7501798077
GSE13712_STATICDown-0.9600608569
GSE19018Down-0.1186069758
GSE19899_A1Up0.0271963471
GSE19899_A2Up0.1949708187
PubMed_21979375_A1Up0.0370574594
PubMed_21979375_A2Down-0.2440975797
GSE35957Down-0.4656018601
GSE36640Up0.0394346397
GSE54402Up0.5937706274
GSE9593Up0.0224246354
GSE43922Up0.0956723948
GSE24585Up0.1129366705
GSE37065Up0.3332746122
GSE28863_A1Down-0.0795559463
GSE28863_A2Up0.8294754989
GSE28863_A3Up0.3161746717
GSE28863_A4Up0.2493873865
GSE48662Up0.0473214903

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

17081159Co-immunoprecipitation experiments revealed that Gravin and AKAP79 do not associate with adenylyl cyclase type 2 (AC2) but bind to AC4/6, which interacts with calcium-dependent PKCs alpha/beta both in young and senescent fibroblasts
17081159We conclude that LPA-dependent increased level of cAMP in senescent human diploid fibroblasts is associated with increases in Gravin levels resulting in its increased binding with and activation of calcium-dependent PKC alpha/beta and AC4/6
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