HCSGD entry for EIF2S3
1. General information
| Official gene symbol | EIF2S3 |
|---|---|
| Entrez ID | 1968 |
| Gene full name | eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa |
| Other gene symbols | EIF2 EIF2G EIF2gamma eIF-2gA |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003743 | Translation initiation factor activity | IDA | molecular_function |
| GO:0003924 | GTPase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005525 | GTP binding | IEA | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006184 | GTP catabolic process | TAS | biological_process |
| GO:0006412 | Translation | TAS | biological_process |
| GO:0006413 | Translational initiation | IDA TAS | biological_process |
| GO:0008135 | Translation factor activity, nucleic acid binding | IDA | molecular_function |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0044267 | Cellular protein metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8851677938 | 0.1382190456 | 0.9999902473 | 0.7160029319 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0810196407 |
| GSE13712_SHEAR | Up | 0.0414330678 |
| GSE13712_STATIC | Up | 0.0357143700 |
| GSE19018 | Down | -0.1816099339 |
| GSE19899_A1 | Down | -0.0986435827 |
| GSE19899_A2 | Up | 0.0208138603 |
| PubMed_21979375_A1 | Up | 0.1316417107 |
| PubMed_21979375_A2 | Down | -0.3730253994 |
| GSE35957 | Up | 0.1159827340 |
| GSE36640 | Down | -0.2746706190 |
| GSE54402 | Down | -0.0567242178 |
| GSE9593 | Up | 0.2208236951 |
| GSE43922 | Down | -0.0048141891 |
| GSE24585 | Down | -0.3312271328 |
| GSE37065 | Down | -0.6086590088 |
| GSE28863_A1 | Up | 0.4059205402 |
| GSE28863_A2 | Down | -0.1153484237 |
| GSE28863_A3 | Down | -0.3067330999 |
| GSE28863_A4 | Up | 0.1446617392 |
| GSE48662 | - | - |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Guanosine-5'-Diphosphate | DB04315 | EXPT01573 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-7-5p | MIMAT0000252 | MIRT025848 | Microarray | Functional MTI (Weak) | 19073608 |
| hsa-miR-98-5p | MIMAT0000096 | MIRT027622 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-24-3p | MIMAT0000080 | MIRT030483 | Microarray | Functional MTI (Weak) | 19748357 |
| hsa-miR-331-3p | MIMAT0000760 | MIRT043305 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-30c-5p | MIMAT0000244 | MIRT047883 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-196a-5p | MIMAT0000226 | MIRT048212 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049409 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
