HCSGD entry for EGR3
1. General information
| Official gene symbol | EGR3 |
|---|---|
| Entrez ID | 1960 |
| Gene full name | early growth response 3 |
| Other gene symbols | EGR-3 PILOT |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001938 | Positive regulation of endothelial cell proliferation | IMP | biological_process |
| GO:0002042 | Cell migration involved in sprouting angiogenesis | IDA | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | TAS | molecular_function |
| GO:0005634 | Nucleus | IBA | cellular_component |
| GO:0005737 | Cytoplasm | IBA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0007274 | Neuromuscular synaptic transmission | IEA | biological_process |
| GO:0007422 | Peripheral nervous system development | IEA | biological_process |
| GO:0007517 | Muscle organ development | TAS | biological_process |
| GO:0007623 | Circadian rhythm | TAS | biological_process |
| GO:0035767 | Endothelial cell chemotaxis | IMP | biological_process |
| GO:0035924 | Cellular response to vascular endothelial growth factor stimulus | IMP | biological_process |
| GO:0043066 | Negative regulation of apoptotic process | IMP | biological_process |
| GO:0044344 | Cellular response to fibroblast growth factor stimulus | IMP | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0071320 | Cellular response to cAMP | IBA | biological_process |
| GO:0071371 | Cellular response to gonadotropin stimulus | IBA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0022391512 | 0.0295610197 | 0.1270187500 | 0.3257851171 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -3.3233466617 |
| GSE13712_SHEAR | Down | -0.6994360153 |
| GSE13712_STATIC | Down | -0.2377099030 |
| GSE19018 | Down | -4.0234871764 |
| GSE19899_A1 | Up | 1.7364727476 |
| GSE19899_A2 | Up | 0.9003982751 |
| PubMed_21979375_A1 | Up | 2.5485563330 |
| PubMed_21979375_A2 | Up | 1.8946615825 |
| GSE35957 | Up | 0.1385710351 |
| GSE36640 | Down | -0.5056487101 |
| GSE54402 | Up | 3.5038687473 |
| GSE9593 | Down | -0.7122687929 |
| GSE43922 | Up | 0.7507570195 |
| GSE24585 | Up | 0.2616520867 |
| GSE37065 | Up | 0.3925643542 |
| GSE28863_A1 | Up | 0.1715322560 |
| GSE28863_A2 | Down | -0.0141603378 |
| GSE28863_A3 | Up | 0.1289255597 |
| GSE28863_A4 | Down | -0.0005091357 |
| GSE48662 | Down | -0.2873272521 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-let-7a-5p | MIMAT0000062 | MIRT004963 | qRT-PCR | Functional MTI (Weak) | 17942906 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT018262 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029689 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
