HCSGD entry for AHR

1. General information

Official gene symbolAHR
Entrez ID196
Gene full namearyl hydrocarbon receptor
Other gene symbolsbHLHe76
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0001568Blood vessel developmentNASbiological_process
GO:0003677DNA bindingIDA TASmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIDAmolecular_function
GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0004871Signal transducer activityIEAmolecular_function
GO:0004879Ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005667Transcription factor complexTAScellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0006355Regulation of transcription, DNA-templatedIDAbiological_process
GO:0006357Regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0006366Transcription from RNA polymerase II promoterIDAbiological_process
GO:0006805Xenobiotic metabolic processTASbiological_process
GO:0006915Apoptotic processTASbiological_process
GO:0006950Response to stressIDAbiological_process
GO:0007049Cell cycleTASbiological_process
GO:0008134Transcription factor bindingIPImolecular_function
GO:0009410Response to xenobiotic stimulusIDAbiological_process
GO:0010468Regulation of gene expressionIDAbiological_process
GO:0030522Intracellular receptor signaling pathwayIDAbiological_process
GO:0030850Prostate gland developmentIEAbiological_process
GO:0030888Regulation of B cell proliferationIDAbiological_process
GO:0034752Cytosolic aryl hydrocarbon receptor complexTAScellular_component
GO:0043565Sequence-specific DNA bindingIEAmolecular_function
GO:0044212Transcription regulatory region DNA bindingIDAmolecular_function
GO:0045899Positive regulation of RNA polymerase II transcriptional preinitiation complex assemblyIEAbiological_process
GO:0046982Protein heterodimerization activityTASmolecular_function
GO:0046983Protein dimerization activityTASmolecular_function
GO:0051879Hsp90 protein bindingIDAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00426379700.44478113290.17602159261.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up1.0278327797
GSE13712_SHEARDown-1.2034601853
GSE13712_STATICDown-0.5306197088
GSE19018Down-0.4770063330
GSE19899_A1Up1.5780967652
GSE19899_A2Up0.7155307529
PubMed_21979375_A1Up1.2905391679
PubMed_21979375_A2Up0.9745077072
GSE35957Down-0.1419387472
GSE36640Up0.9475530123
GSE54402Up0.5000432720
GSE9593Up0.4414718506
GSE43922Up0.4415981913
GSE24585Up0.0400679855
GSE37065Up0.2582440657
GSE28863_A1Up0.1164913179
GSE28863_A2Up1.0101230262
GSE28863_A3Down-0.4389555386
GSE28863_A4Down-0.5988037502
GSE48662Up0.4195738714

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Compound

Target

Confidence score

Uniprot

CHEMBL150CHEMBL32018P35869
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  • Drugs

Name

Drug

Accession number

MexiletineDB00379 APRD00242
FlutamideDB00499 APRD00984
AtorvastatinDB01076 APRD00055
GinsengDB01404 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-124-3pMIMAT0000422MIRT002653MicroarrayFunctional MTI (Weak)15685193
hsa-miR-124-3pMIMAT0000422MIRT002653Luciferase reporter assay//Western blotFunctional MTI22024478
hsa-miR-130b-3pMIMAT0000691MIRT020178SequencingFunctional MTI (Weak)20371350
hsa-miR-98-5pMIMAT0000096MIRT027562MicroarrayFunctional MTI (Weak)19088304
hsa-miR-625-5pMIMAT0003294MIRT039593CLASHFunctional MTI (Weak)23622248
hsa-miR-26a-5pMIMAT0000082MIRT050123CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25938935Stress-mediated post-translational modification of molecular clock proteins, brain and muscle aryl hydrocarbon receptor nuclear translocator-like 1 (BMAL1) and PERIOD 2, is associated with a reduction in the activity/level of the deacetylase sirtuin 1 (SIRT1)
24885022Estrogen receptor alpha and aryl hydrocarbon receptor independent growth inhibitory effects of aminoflavone in breast cancer cells
24885022BACKGROUND: Numerous studies have implicated the aryl hydrocarbon receptor (AhR) as a potential therapeutic target for several human diseases, including estrogen receptor alpha (ERalpha) positive breast cancer
24885022Aminoflavone (AF), an activator of AhR signaling, is currently undergoing clinical evaluation for the treatment of solid tumors
24885022Here, we examined AF's effects on two TNBC cell lines and the role of AhR signaling in AF sensitivity in these model cell lines
24885022The requirement of endogenous levels of AhR and AhR signaling for AF sensitivity was examined in MDA-MB-468 and Cal51 cells stably harboring inducible shRNA for AhR
24885022Further, we presented evidence suggesting that neither endogenous AhR expression levels nor downstream induction of AhR target genes CYP1A1 and CYP1B1 is required for AF-mediated growth inhibition in these cells
24885022CONCLUSIONS: Overall, this work provides evidence against the simplified view of AF sensitivity, and suggests that AF could mediate growth inhibitory effects in ERalpha-positive and negative breast cancer cells, as well as cells with impaired AhR expression and signaling
24727683We recently reported that indoxyl sulfate (IS), a uremic toxin, directly activates aryl hydrocarbon receptor (AhR) and generates oxidative stress through NADPH oxidase-4 in human umbilical vein endothelial cells (HUVECs)
24727683In the current study, we sought to examine whether IS regulates sirtuin 1 (Sirt1) and affects endothelial senescence via AhR activation
24727683Furthermore, we evaluated the involvement of AhR in the senescence-related changes induced by IS using AhR antagonists
24727683On the other hand, the AhR antagonists restored the IS-induced decrease in the NAD() content in association with an improvement in the iNampt activity and ameliorated the senescence-related changes
24727683Taken together, these results indicate that IS impairs the iNampt-NAD()-Sirt1 system via AhR activation, which in turn promotes endothelial senescence
24727683Therefore, blocking the effects of AhR in the endothelium may provide a new therapeutic tool for treating cardio-renal syndrome
21444158Could Malassezia yeasts be implicated in skin carcinogenesis through the production of aryl-hydrocarbon receptor ligands
21444158In vitro they have the ability to synthesize potent ligands (indolo[3,2-b]carbazole, malassezin and indirubin) of the aryl-hydrocarbon receptor (AhR; synonym: dioxin receptor) when the sweat contained L-tryptophan is used as the single nitrogen source
21444158AhR is associated with carcinogenesis and the potential connection of these ubiquitous skin symbionts, and putative pathogens, with skin neoplasia should be evaluated mainly focusing on mechanisms related to the distinctive ability of the yeast to produce potent AhR ligands
21444158HYPOTHESIS: Synthesis of available pertinent data show a possible link between Malassezia produced AhR ligands and skin carcinogenesis, particularly of basal cell carcinoma (BCC)
21444158The potent AhR ligands synthesized by pathogenic Malassezia strains could contribute to tumor promotion by: modification of the UV radiation carcinogenesis, alterations in the salvage/survival of initiated tumor cells, inhibition of cell senescence, interaction with vitamin D metabolism, promotion of immune tolerance and finally pro-carcinogenic modulation of cell cycle progression and apoptosis
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