HCSGD entry for EGR2
1. General information
| Official gene symbol | EGR2 |
|---|---|
| Entrez ID | 1959 |
| Gene full name | early growth response 2 |
| Other gene symbols | AT591 CMT1D CMT4E KROX20 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001102 | RNA polymerase II activating transcription factor binding | ISS | molecular_function |
| GO:0003682 | Chromatin binding | ISS | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IBA IC ISS | cellular_component |
| GO:0005737 | Cytoplasm | IBA ISS | cellular_component |
| GO:0006366 | Transcription from RNA polymerase II promoter | ISS | biological_process |
| GO:0006611 | Protein export from nucleus | ISS | biological_process |
| GO:0007420 | Brain development | TAS | biological_process |
| GO:0007422 | Peripheral nervous system development | TAS | biological_process |
| GO:0007611 | Learning or memory | IEA | biological_process |
| GO:0007622 | Rhythmic behavior | IEA | biological_process |
| GO:0008045 | Motor neuron axon guidance | IEA | biological_process |
| GO:0014037 | Schwann cell differentiation | IEA | biological_process |
| GO:0016874 | Ligase activity | IEA | molecular_function |
| GO:0016925 | Protein sumoylation | IEA | biological_process |
| GO:0021612 | Facial nerve structural organization | IEA | biological_process |
| GO:0021660 | Rhombomere 3 formation | IEA | biological_process |
| GO:0021666 | Rhombomere 5 formation | IEA | biological_process |
| GO:0030278 | Regulation of ossification | IEA | biological_process |
| GO:0031625 | Ubiquitin protein ligase binding | IPI | molecular_function |
| GO:0032868 | Response to insulin | IEA | biological_process |
| GO:0035284 | Brain segmentation | IEA | biological_process |
| GO:0035914 | Skeletal muscle cell differentiation | IBA | biological_process |
| GO:0042552 | Myelination | IBA | biological_process |
| GO:0043066 | Negative regulation of apoptotic process | IBA | biological_process |
| GO:0044212 | Transcription regulatory region DNA binding | ISS | molecular_function |
| GO:0045444 | Fat cell differentiation | ISS | biological_process |
| GO:0045893 | Positive regulation of transcription, DNA-templated | ISS | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0048168 | Regulation of neuronal synaptic plasticity | IBA | biological_process |
| GO:0071320 | Cellular response to cAMP | IBA | biological_process |
| GO:0071371 | Cellular response to gonadotropin stimulus | IBA | biological_process |
| GO:0071837 | HMG box domain binding | IEA | molecular_function |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0048106075 | 0.2546976597 | 0.1824495677 | 0.9677922766 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -1.6032404297 |
| GSE13712_SHEAR | Down | -0.0360637716 |
| GSE13712_STATIC | Down | -0.0820617291 |
| GSE19018 | Down | -1.4154885768 |
| GSE19899_A1 | Up | 0.5339300705 |
| GSE19899_A2 | Up | 0.6323580191 |
| PubMed_21979375_A1 | Up | 1.6482953136 |
| PubMed_21979375_A2 | Up | 1.5112626197 |
| GSE35957 | Down | -0.7731755305 |
| GSE36640 | Up | 0.3055459673 |
| GSE54402 | Up | 2.1544105230 |
| GSE9593 | Down | -0.8907985622 |
| GSE43922 | Up | 0.5716473139 |
| GSE24585 | Up | 0.2966679018 |
| GSE37065 | Up | 0.5957645437 |
| GSE28863_A1 | Down | -0.0988456345 |
| GSE28863_A2 | Down | -0.1287481001 |
| GSE28863_A3 | Up | 0.1782236805 |
| GSE28863_A4 | Up | 0.0801174840 |
| GSE48662 | Up | 1.7041948409 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-150-5p | MIMAT0000451 | MIRT003222 | Luciferase reporter assay//semi-qRT-PCR//Western blot | Functional MTI | 20067763 |
| hsa-miR-100-5p | MIMAT0000098 | MIRT003417 | Microarray//qRT-PCR | Functional MTI (Weak) | 19396866 |
| hsa-miR-130b-3p | MIMAT0000691 | MIRT020183 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT022653 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT028079 | Sequencing | Functional MTI (Weak) | 20371350 |
Entries Per Page
Displaying Page of
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-150-5p | MIMAT0000451 | 1 | hsa-miR-150 | 20067763 |
Entries Per Page
Displaying Page of
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
