HCSGD entry for EGR1

1. General information

Official gene symbolEGR1
Entrez ID1958
Gene full nameearly growth response 1
Other gene symbolsAT225 G0S30 KROX-24 NGFI-A TIS8 ZIF-268 ZNF225
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0000976Transcription regulatory region sequence-specific DNA bindingIDAmolecular_function
GO:0000979RNA polymerase II core promoter sequence-specific DNA bindingIEAmolecular_function
GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionIEAmolecular_function
GO:0001975Response to amphetamineIEAbiological_process
GO:0003677DNA bindingIDAmolecular_function
GO:0003690Double-stranded DNA bindingIEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA ISScellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005737CytoplasmIDA ISScellular_component
GO:0006366Transcription from RNA polymerase II promoterIDAbiological_process
GO:0007611Learning or memoryIEAbiological_process
GO:0007623Circadian rhythmIEAbiological_process
GO:0008134Transcription factor bindingIEAmolecular_function
GO:0009749Response to glucoseIEAbiological_process
GO:0019221Cytokine-mediated signaling pathwayTASbiological_process
GO:0030217T cell differentiationIEAbiological_process
GO:0030509BMP signaling pathwayIEAbiological_process
GO:0031667Response to nutrient levelsIEAbiological_process
GO:0032869Cellular response to insulin stimulusIEAbiological_process
GO:0033233Regulation of protein sumoylationIDAbiological_process
GO:0034465Response to carbon monoxideIEAbiological_process
GO:0035035Histone acetyltransferase bindingIPImolecular_function
GO:0035690Cellular response to drugIEAbiological_process
GO:0035914Skeletal muscle cell differentiationIBAbiological_process
GO:0042220Response to cocaineIEAbiological_process
GO:0043066Negative regulation of apoptotic processIBAbiological_process
GO:0043525Positive regulation of neuron apoptotic processIEAbiological_process
GO:0043565Sequence-specific DNA bindingIDAmolecular_function
GO:0045471Response to ethanolIEAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDA IMPbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048169Regulation of long-term neuronal synaptic plasticityIBAbiological_process
GO:0048709Oligodendrocyte differentiationIEAbiological_process
GO:0051602Response to electrical stimulusIEAbiological_process
GO:0060291Long-term synaptic potentiationIEAbiological_process
GO:0060337Type I interferon signaling pathwayTASbiological_process
GO:0070498Interleukin-1-mediated signaling pathwayIMPbiological_process
GO:0071236Cellular response to antibioticIEAbiological_process
GO:0071260Cellular response to mechanical stimulusIEAbiological_process
GO:0071317Cellular response to isoquinoline alkaloidIEAbiological_process
GO:0071320Cellular response to cAMPIBAbiological_process
GO:0071363Cellular response to growth factor stimulusIEAbiological_process
GO:0071371Cellular response to gonadotropin stimulusIBAbiological_process
GO:0071372Cellular response to follicle-stimulating hormone stimulusIEAbiological_process
GO:0071383Cellular response to steroid hormone stimulusIEAbiological_process
GO:0071455Cellular response to hyperoxiaIEAbiological_process
GO:0071456Cellular response to hypoxiaIEAbiological_process
GO:0071480Cellular response to gamma radiationIEAbiological_process
GO:0071504Cellular response to heparinISSbiological_process
GO:0071506Cellular response to mycophenolic acidISSbiological_process
GO:0071873Response to norepinephrineIEAbiological_process
GO:0072110Glomerular mesangial cell proliferationISSbiological_process
GO:0072303Positive regulation of glomerular metanephric mesangial cell proliferationISSbiological_process
GO:0090090Negative regulation of canonical Wnt signaling pathwayIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.04312869950.04508656210.46221111560.3991464046

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-1.7263089182
GSE13712_SHEARUp0.1772960707
GSE13712_STATICUp0.5042105627
GSE19018Down-0.7355823011
GSE19899_A1Up1.1369208544
GSE19899_A2Down-0.2994142386
PubMed_21979375_A1Up1.0713190797
PubMed_21979375_A2Up0.3012369234
GSE35957Down-0.3150476211
GSE36640Down-1.5967099178
GSE54402Up0.7575469981
GSE9593Down-0.8718685595
GSE43922Up0.1363246831
GSE24585Down-0.0121749849
GSE37065Up0.6599767160
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Up0.2236308322

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-183-5pMIMAT0000261MIRT006540Luciferase reporter assayFunctional MTI21118966
hsa-miR-192-5pMIMAT0000222MIRT004130MicroarrayFunctional MTI (Weak)16822819
hsa-miR-192-5pMIMAT0000222MIRT004130MicroarrayFunctional MTI (Weak)19074876
hsa-miR-124-3pMIMAT0000422MIRT023192MicroarrayFunctional MTI (Weak)18668037
hsa-miR-215-5pMIMAT0000272MIRT024271MicroarrayFunctional MTI (Weak)19074876
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 6 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24782600Detailed analysis of the above changes indicates that the following events occur in aging gastric mucosa: reduced mucosal blood flow and impaired oxygen delivery cause hypoxia, which leads to activation of the early growth response-1 (egr-1) transcription factor
20348948We show EGR1 is required for the ability of TBX2 to repress NDRG1 and drive cell proliferation
20348948We show that TBX2 interacts with EGR1 and that TBX2 requires EGR1 to target the NDRG1 proximal promoter
20348948Abrogation of either TBX2 or EGR1 expression is accompanied by the upregulation of cell senescence and apoptotic markers
18202802Induction of apoptosis by pectenotoxin-2 is mediated with the induction of DR4/DR5, Egr-1 and NAG-1, activation of caspases and modulation of the Bcl-2 family in p53-deficient Hep3B hepatocellular carcinoma cells
12629205Early growth response 1 protein, an upstream gatekeeper of the p53 tumor suppressor, controls replicative senescence
12629205We find that deletion of the early growth response 1 (EGR1) transcription factor leads to a striking phenotype, including complete bypass of senescence and apparent immortal growth consistent with loss of a suppressor gene
12629205Taken together, the results establish EGR1 as a major regulator of cell senescence and previously undescribed upstream "gatekeeper" of the p53 tumor suppressor pathway
12172426Microarrays have also been used to characterize gene expression changes associated with androgen stimulation, the activation of EGR1 pathways, and prostate epithelial cellular senescence
10082129Decreased expression and activity of the immediate-early growth response (Egr-1) gene product during cellular senescence
10082129Here we examined the expression and activity of the early growth response-1 (egr-1) gene, an "immediate-early" gene that is believed to link extracellular mitogenic signals to cell-cycle progression
10082129Decreased DNA binding activity of Egr-1 in vitro corresponded to decreased transcriptional activation in vivo
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