HCSGD entry for EEF1A1
1. General information
| Official gene symbol | EEF1A1 |
|---|---|
| Entrez ID | 1915 |
| Gene full name | eukaryotic translation elongation factor 1 alpha 1 |
| Other gene symbols | CCS-3 CCS3 EE1A1 EEF-1 EEF1A EF-Tu EF1A GRAF-1EF HNGC:16303 LENG7 PTI1 eEF1A-1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003746 | Translation elongation factor activity | TAS | molecular_function |
| GO:0003924 | GTPase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005525 | GTP binding | IEA TAS | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IEA ISS TAS | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005853 | Eukaryotic translation elongation factor 1 complex | TAS | cellular_component |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0006412 | Translation | TAS | biological_process |
| GO:0006414 | Translational elongation | TAS | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0019901 | Protein kinase binding | IPI | molecular_function |
| GO:0044267 | Cellular protein metabolic process | TAS | biological_process |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8795267429 | 0.2181573952 | 0.9999902473 | 0.8988917971 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0375753443 |
| GSE13712_SHEAR | Down | -0.2166233171 |
| GSE13712_STATIC | Down | -0.2797294186 |
| GSE19018 | Up | 0.0082747294 |
| GSE19899_A1 | Down | -0.2466624865 |
| GSE19899_A2 | Down | -0.2772602274 |
| PubMed_21979375_A1 | Down | -0.5576296944 |
| PubMed_21979375_A2 | Down | -0.5131692345 |
| GSE35957 | Up | 0.2923043049 |
| GSE36640 | Up | 0.0092442166 |
| GSE54402 | Down | -0.1346213221 |
| GSE9593 | Up | 0.0704439815 |
| GSE43922 | Down | -0.1096807081 |
| GSE24585 | Down | -0.1938675604 |
| GSE37065 | Down | -0.1423604508 |
| GSE28863_A1 | Up | 0.0999318592 |
| GSE28863_A2 | Up | 0.3870934161 |
| GSE28863_A3 | Up | 0.2125699418 |
| GSE28863_A4 | Up | 0.2159099078 |
| GSE48662 | Up | 0.0551242678 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Guanosine-5'-Diphosphate | DB04315 | EXPT01573 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-16-5p | MIMAT0000069 | MIRT031618 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031618 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-1226-3p | MIMAT0005577 | MIRT036484 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-877-5p | MIMAT0004949 | MIRT037373 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-455-3p | MIMAT0004784 | MIRT037887 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-361-3p | MIMAT0004682 | MIRT038270 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-296-3p | MIMAT0004679 | MIRT038433 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-93-3p | MIMAT0004509 | MIRT038724 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-421 | MIMAT0003339 | MIRT039430 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-652-3p | MIMAT0003322 | MIRT039465 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040041 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-505-3p | MIMAT0002876 | MIRT041069 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-501-5p | MIMAT0002872 | MIRT041144 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-497-5p | MIMAT0002820 | MIRT041183 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT041803 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-423-3p | MIMAT0001340 | MIRT042476 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-339-5p | MIMAT0000764 | MIRT042754 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-3p | MIMAT0000762 | MIRT042916 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-340-3p | MIMAT0000750 | MIRT043857 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-30e-5p | MIMAT0000692 | MIRT044159 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-106b-5p | MIMAT0000680 | MIRT044291 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT044909 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-185-5p | MIMAT0000455 | MIRT045351 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-125a-5p | MIMAT0000443 | MIRT045725 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-125b-5p | MIMAT0000423 | MIRT045935 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-23b-3p | MIMAT0000418 | MIRT046331 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-15b-5p | MIMAT0000417 | MIRT046401 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7g-5p | MIMAT0000414 | MIRT046556 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT046863 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-30c-5p | MIMAT0000244 | MIRT047870 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-197-3p | MIMAT0000227 | MIRT048051 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-100-5p | MIMAT0000098 | MIRT048484 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-96-5p | MIMAT0000095 | MIRT048716 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT048759 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049131 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-30a-5p | MIMAT0000087 | MIRT049950 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT050042 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-25-3p | MIMAT0000081 | MIRT050247 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-24-3p | MIMAT0000080 | MIRT050378 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-18a-5p | MIMAT0000072 | MIRT050679 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT050841 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT051968 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-1260b | MIMAT0015041 | MIRT052768 | CLASH | Functional MTI (Weak) | 23622248 |
Entries Per Page
Displaying Page of
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 6 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27036204 | Using Western blot analysis, we validated the down-regulation of AKR1B1, EEF2, EEF1A1, and HSP90 and the up-regulation of VIM in P6 cells seen in the LC-MS data |
| 26610640 | Plasma levels of cell senescence markers stathmin, chitinase 1/3, elongation factor 1-alpha were determined |
| 24626611 | A variety of senescence-associated biomarkers including cathepsin D (CD), the eukaryotic translation elongation factors eEF1A1, eEF1B2, decoy receptor 2 and Dec1 were further validated in vivo or in vitro |
| 20545466 | Increased expression of elongation factor-1alpha is significantly correlated with poor prognosis of human prostate cancer |
| 20099848 | Identification of Rack1, EF-Tu and Rhodanese as aging-related proteins in human colonic epithelium by proteomic analysis |
| 20099848 | Rack1, EF-Tu and Rhodanese, three validated differential proteins, were further investigated for their role in the in vitro cell senescence |
| 20099848 | Taken together, our results suggest that Rack1, EF-Tu and Rhodanese are aging-related proteins in human colonic epithelium, and injury of mitochondrial function and decline of antioxidant capability are important reasons for the aging of human colonic epithelium |
| 19487283 | The other elongation factor, eukaryotic translation elongation factor 1alpha1 (eEF1A1), was also down-regulated |
| 19487283 | IR-induced senescence was associated with similar changes of CD and eEF1 (eEF1A1 and eEF1B2) levels in the HCT116 colon cancer cell line and the H460 lung cancer cell line |
| 19487283 | The same alterations in CD and eEF1A1 levels were observed during replicative senescence and Ras oncogene-induced senescence |
Entries Per Page
Displaying Page of
