HCSGD entry for AHCY
1. General information
| Official gene symbol | AHCY |
|---|---|
| Entrez ID | 191 |
| Gene full name | adenosylhomocysteinase |
| Other gene symbols | SAHH adoHcyase |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000096 | Sulfur amino acid metabolic process | TAS | biological_process |
| GO:0004013 | Adenosylhomocysteinase activity | TAS | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006730 | One-carbon metabolic process | IEA | biological_process |
| GO:0006805 | Xenobiotic metabolic process | TAS | biological_process |
| GO:0032259 | Methylation | TAS | biological_process |
| GO:0034641 | Cellular nitrogen compound metabolic process | TAS | biological_process |
| GO:0042470 | Melanosome | IEA | cellular_component |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0090801603 | 0.8974430873 | 0.2438764286 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3800363233 |
| GSE13712_SHEAR | Up | 0.4865597228 |
| GSE13712_STATIC | Up | 0.4716186710 |
| GSE19018 | Down | -0.1919267078 |
| GSE19899_A1 | Up | 0.7053944299 |
| GSE19899_A2 | Up | 0.9703202401 |
| PubMed_21979375_A1 | Up | 1.2513208697 |
| PubMed_21979375_A2 | Up | 1.7088600086 |
| GSE35957 | Down | -0.1674322571 |
| GSE36640 | Up | 0.1204289136 |
| GSE54402 | Up | 0.6591146980 |
| GSE9593 | Up | 0.1348689908 |
| GSE43922 | Up | 0.6340898584 |
| GSE24585 | Down | -0.0886304600 |
| GSE37065 | Down | -0.4311324748 |
| GSE28863_A1 | Up | 0.0669215942 |
| GSE28863_A2 | Down | -0.1543664974 |
| GSE28863_A3 | Down | -0.5534002229 |
| GSE28863_A4 | Up | 0.0061146809 |
| GSE48662 | Up | 0.2769593094 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Isopropyl Alcohol | DB02325 | EXPT01912 | DB04402 |
| (1'r,2's)-9-(2-Hydroxy-3'-Keto-Cyclopenten-1-Yl)Adenine | DB03216 | EXPT00427 |
| 3'-Oxo-Adenosine | DB03273 | EXPT00442 |
| D-Eritadenine | DB03769 | EXPT01152 |
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 15488656 | S-adenosylhomocysteine hydrolase, S-adenosylmethionine, S-adenosylhomocysteine: correlations with ribavirin induced anemia |
| 2383922 | S-adenosylhomocysteine hydrolase and adenosine deaminase activities in human red cell ageing |
| 2383922 | The enzyme activities of S-adenosylhomocysteine hydrolase, adenosine deaminase and pyruvate kinase were determined in normal human erythrocytes subpopulations of different ages separated by centrifugation on a discontinuous Percoll:NaCl density gradient |
| 2383922 | The levels of S-adenosylhomocysteine hydrolase activity were found to undergo a sharp decrease with red cell ageing |
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