HCSGD entry for S1PR1

1. General information

Official gene symbolS1PR1
Entrez ID1901
Gene full namesphingosine-1-phosphate receptor 1
Other gene symbolsCD363 CHEDG1 D1S3362 ECGF1 EDG-1 EDG1 S1P1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001525AngiogenesisIEAbiological_process
GO:0001955Blood vessel maturationISSbiological_process
GO:0003245Cardiac muscle tissue growth involved in heart morphogenesisISSbiological_process
GO:0003376Sphingosine-1-phosphate signaling pathwayIDAbiological_process
GO:0004930G-protein coupled receptor activityTASmolecular_function
GO:0005768EndosomeIEAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0006935ChemotaxisISSbiological_process
GO:0007155Cell adhesionTASbiological_process
GO:0007186G-protein coupled receptor signaling pathwayTASbiological_process
GO:0007193Adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0007420Brain developmentIEAbiological_process
GO:0009897External side of plasma membraneIEAcellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0016477Cell migrationISSbiological_process
GO:0019226Transmission of nerve impulseIEAbiological_process
GO:0030032Lamellipodium assemblyISSbiological_process
GO:0030155Regulation of cell adhesionIEAbiological_process
GO:0030182Neuron differentiationIEAbiological_process
GO:0030335Positive regulation of cell migrationIEAbiological_process
GO:0030500Regulation of bone mineralizationISSbiological_process
GO:0031226Intrinsic component of plasma membraneIDAcellular_component
GO:0031532Actin cytoskeleton reorganizationISSbiological_process
GO:0032320Positive regulation of Ras GTPase activityIEAbiological_process
GO:0038036Sphingosine-1-phosphate receptor activityIDAmolecular_function
GO:0045121Membrane raftIEAcellular_component
GO:0045124Regulation of bone resorptionISSbiological_process
GO:0045446Endothelial cell differentiationIEAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0046625Sphingolipid bindingIEAmolecular_function
GO:0048661Positive regulation of smooth muscle cell proliferationIEAbiological_process
GO:0050927Positive regulation of positive chemotaxisIEAbiological_process
GO:0051482Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwayIEAbiological_process
GO:0051497Negative regulation of stress fiber assemblyIEAbiological_process
GO:0061384Heart trabecula morphogenesisISSbiological_process
GO:0072678T cell migrationISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.98876108050.00080734390.99999024730.0536618687

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0987821438
GSE13712_SHEARUp0.1849496738
GSE13712_STATICUp0.0912536078
GSE19018Down-0.8763758140
GSE19899_A1Down-0.2110231913
GSE19899_A2Down-1.8651475032
PubMed_21979375_A1Down-2.2494521703
PubMed_21979375_A2Down-0.6064803370
GSE35957Down-0.3544763392
GSE36640Up0.5810159714
GSE54402Down-2.1912859042
GSE9593Down-0.7059404270
GSE43922Down-0.5709380756
GSE24585Down-0.2371189539
GSE37065Down-0.1529615848
GSE28863_A1Up0.0755416858
GSE28863_A2Down-0.6300711079
GSE28863_A3Up0.0230850036
GSE28863_A4Down-0.4555236821
GSE48662Down-1.3484652958

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Asfotase AlfaDB09105 -

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

18765664Increased expression of S1P(1) and S1P(2) was also observed in the lesion regions of atherosclerotic endothelium, where senescent ECs have been identified in vivo
12646237EDG-1 and EDG-4 were unchanged, but EDG-2 and EDG-7 were reduced with age
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