HCSGD entry for E2F6
1. General information
| Official gene symbol | E2F6 |
|---|---|
| Entrez ID | 1876 |
| Gene full name | E2F transcription factor 6 |
| Other gene symbols | E2F-6 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000083 | Regulation of transcription involved in G1/S transition of mitotic cell cycle | IEA | biological_process |
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0003714 | Transcription corepressor activity | TAS | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0005667 | Transcription factor complex | IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0071339 | MLL1 complex | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1157077315 | 0.7392093917 | 0.6985190826 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0134524094 |
| GSE13712_SHEAR | Down | -0.0391921366 |
| GSE13712_STATIC | Up | 0.2521985168 |
| GSE19018 | Down | -0.6475746015 |
| GSE19899_A1 | Up | 0.2910670777 |
| GSE19899_A2 | Up | 0.5534260838 |
| PubMed_21979375_A1 | Up | 0.7728842530 |
| PubMed_21979375_A2 | Up | 0.4772023238 |
| GSE35957 | Down | -0.4445414984 |
| GSE36640 | Up | 0.0112926858 |
| GSE54402 | Up | 0.4853971043 |
| GSE9593 | Up | 0.1387086902 |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | Up | 0.1159032759 |
| GSE28863_A2 | Up | 0.2600960810 |
| GSE28863_A3 | Down | -0.1037674747 |
| GSE28863_A4 | Down | -0.0096071802 |
| GSE48662 | Down | -0.0875464266 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-151a-5p | MIMAT0004697 | MIRT006420 | Luciferase reporter assay | Functional MTI | 20445018 |
| hsa-miR-28-5p | MIMAT0000085 | MIRT006419 | Luciferase reporter assay | Functional MTI | 20445018 |
| hsa-miR-193a-3p | MIMAT0000459 | MIRT002487 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 18381414 |
| hsa-miR-137 | MIMAT0000429 | MIRT002489 | Luciferase reporter assay//qRT-PCR//Western blot | Non-Functional MTI | 18381414 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT004726 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 19843643 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT005044 | Microarray | Functional MTI (Weak) | 17699775 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016420 | Microarray | Functional MTI (Weak) | 20304954 |
| hsa-miR-98-5p | MIMAT0000096 | MIRT027682 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-137 | MIMAT0000429 | NA | hsa-miR-137 | {Western blot} | {overexpression by miRNA precursor transfection} | 18381414 | |
| hsa-miR-193a-3p | MIMAT0000459 | 1 | hsa-miR-193a-3p | {Western blot} | {overexpression by miRNA precursor transfection} | 18381414 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
