HCSGD entry for AGTR2

1. General information

Official gene symbolAGTR2
Entrez ID186
Gene full nameangiotensin II receptor, type 2
Other gene symbolsAT2 ATGR2 MRX88
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001974Blood vessel remodelingTASbiological_process
GO:0001991Regulation of systemic arterial blood pressure by circulatory renin-angiotensinISSbiological_process
GO:0002018Renin-angiotensin regulation of aldosterone productionIEAbiological_process
GO:0002033Vasodilation by angiotensin involved in regulation of systemic arterial blood pressureIEAbiological_process
GO:0002035Brain renin-angiotensin systemIEAbiological_process
GO:0004945Angiotensin type II receptor activityIPImolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneICcellular_component
GO:0006883Cellular sodium ion homeostasisIEAbiological_process
GO:0006954Inflammatory responseIEAbiological_process
GO:0007166Cell surface receptor signaling pathwayIDAbiological_process
GO:0007186G-protein coupled receptor signaling pathwayICbiological_process
GO:0007199G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messengerISSbiological_process
GO:0007263Nitric oxide mediated signal transductionIC TASbiological_process
GO:0007420Brain developmentNASbiological_process
GO:0007610BehaviorIEAbiological_process
GO:0008134Transcription factor bindingIEAmolecular_function
GO:0008217Regulation of blood pressureTASbiological_process
GO:0008284Positive regulation of cell proliferationIEAbiological_process
GO:0010243Response to organonitrogen compoundIEAbiological_process
GO:0010459Negative regulation of heart rateISSbiological_process
GO:0010469Regulation of receptor activityTASbiological_process
GO:0010700Negative regulation of norepinephrine secretionIEAbiological_process
GO:0017046Peptide hormone bindingIEAmolecular_function
GO:0021695Cerebellar cortex developmentIEAbiological_process
GO:0030308Negative regulation of cell growthTASbiological_process
GO:0032304Negative regulation of icosanoid secretionIEAbiological_process
GO:0032516Positive regulation of phosphoprotein phosphatase activityIDAbiological_process
GO:0035556Intracellular signal transductionISSbiological_process
GO:0035566Regulation of metanephros sizeIEAbiological_process
GO:0035815Positive regulation of renal sodium excretionIEAbiological_process
GO:0035932Aldosterone secretionIEAbiological_process
GO:0038166Angiotensin-activated signaling pathwayIPI TASbiological_process
GO:0042416Dopamine biosynthetic processIEAbiological_process
GO:0042990Regulation of transcription factor import into nucleusIEAbiological_process
GO:0043537Negative regulation of blood vessel endothelial cell migrationNASbiological_process
GO:0045429Positive regulation of nitric oxide biosynthetic processICbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIEAbiological_process
GO:0045909Positive regulation of vasodilationIDAbiological_process
GO:0048019Receptor antagonist activityTASmolecular_function
GO:0048147Negative regulation of fibroblast proliferationIEAbiological_process
GO:0048471Perinuclear region of cytoplasmIEAcellular_component
GO:0050715Positive regulation of cytokine secretionIEAbiological_process
GO:0051000Positive regulation of nitric-oxide synthase activityISSbiological_process
GO:0051387Negative regulation of neurotrophin TRK receptor signaling pathwayIMPbiological_process
GO:0061049Cell growth involved in cardiac muscle cell developmentIEAbiological_process
GO:0071549Cellular response to dexamethasone stimulusIEAbiological_process
GO:0072300Positive regulation of metanephric glomerulus developmentIEAbiological_process
GO:0090190Positive regulation of branching involved in ureteric bud morphogenesisIEAbiological_process
GO:1900116Extracellular negative regulation of signal transductionTASbiological_process
GO:2000272Negative regulation of receptor activityTASbiological_process
GO:2001238Positive regulation of extrinsic apoptotic signaling pathwayIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.84622284870.75589278900.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0585665253
GSE13712_SHEARDown-0.0088209156
GSE13712_STATICUp0.0241947604
GSE19018Up0.1067090443
GSE19899_A1Up0.0842295018
GSE19899_A2Up0.1768823935
PubMed_21979375_A1Down-0.0261224945
PubMed_21979375_A2Down-0.1264076100
GSE35957Up0.0293393363
GSE36640Up0.0721373688
GSE54402Up0.0641579393
GSE9593Down-0.0954049720
GSE43922Up0.0200381774
GSE24585Up0.0837999731
GSE37065Down-0.0993359396
GSE28863_A1Down-0.0714194594
GSE28863_A2Down-0.0898186794
GSE28863_A3Down-0.0199915999
GSE28863_A4Up0.0393763981
GSE48662Down-0.0834050340

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

TasosartanDB01349 -
CYT006-AngQbDB05739 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-148b-3pMIMAT0000759MIRT019253MicroarrayFunctional MTI (Weak)17612493
hsa-miR-142-3pMIMAT0000434MIRT021590MicroarrayFunctional MTI (Weak)17612493
hsa-miR-124-3pMIMAT0000422MIRT022332MicroarrayFunctional MTI (Weak)18668037
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25487516Activation of intracellular angiotensin AT(2) receptors induces rapid cell death in human uterine leiomyosarcoma cells
25487516The presence of angiotensin type 2 (AT(2)) receptors in mitochondria and their role in NO generation and cell aging were recently demonstrated in various human and mouse non-tumour cells
25487516We investigated the intracellular distribution of AT(2) receptors including their presence in mitochondria and their role in the induction of apoptosis and cell death in cultured human uterine leiomyosarcoma (SK-UT-1) cells and control human uterine smooth muscle cells (HutSMC)
25487516The intracellular levels of the AT(2) receptor are low in proliferating SK-UT-1 cells but the receptor is substantially up-regulated in quiescent SK-UT-1 cells with high densities in mitochondria
25487516We demonstrate for the first time that the high-affinity, non-peptide AT(2) receptor agonist, Compound 21 (C21), penetrates the cell membrane of quiescent SK-UT-1 cells, activates intracellular AT(2) receptors and induces rapid cell death; approximately 70% of cells died within 24 h
25487516Our results point to a new, unique approach enabling the elimination non-cycling uterine leiomyosarcoma cells providing that they over-express the AT(2) receptor
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