HCSGD entry for DYRK1A
1. General information
| Official gene symbol | DYRK1A |
|---|---|
| Entrez ID | 1859 |
| Gene full name | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A |
| Other gene symbols | DYRK DYRK1 HP86 MNB MNBH MRD7 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0004672 | Protein kinase activity | TAS | molecular_function |
| GO:0004674 | Protein serine/threonine kinase activity | IEA ISS | molecular_function |
| GO:0004712 | Protein serine/threonine/tyrosine kinase activity | IEA | molecular_function |
| GO:0004713 | Protein tyrosine kinase activity | IEA ISS | molecular_function |
| GO:0004715 | Non-membrane spanning protein tyrosine kinase activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | ISS | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0006468 | Protein phosphorylation | ISS | biological_process |
| GO:0007399 | Nervous system development | TAS | biological_process |
| GO:0007623 | Circadian rhythm | IEA ISS | biological_process |
| GO:0016607 | Nuclear speck | IEA ISS | cellular_component |
| GO:0018105 | Peptidyl-serine phosphorylation | IEA | biological_process |
| GO:0018107 | Peptidyl-threonine phosphorylation | IEA ISS | biological_process |
| GO:0018108 | Peptidyl-tyrosine phosphorylation | IDA ISS | biological_process |
| GO:0030529 | Ribonucleoprotein complex | IEA | cellular_component |
| GO:0043518 | Negative regulation of DNA damage response, signal transduction by p53 class mediator | IEA ISS | biological_process |
| GO:0043621 | Protein self-association | IEA ISS | molecular_function |
| GO:0046777 | Protein autophosphorylation | IEA ISS | biological_process |
| GO:0048156 | Tau protein binding | IEA ISS | molecular_function |
| GO:0090312 | Positive regulation of protein deacetylation | IEA ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2903349455 | 0.7712585198 | 0.9896025628 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0426697380 |
| GSE13712_SHEAR | Up | 0.0092960986 |
| GSE13712_STATIC | Down | -0.0509485387 |
| GSE19018 | Down | -0.0487422391 |
| GSE19899_A1 | Down | -0.1047093387 |
| GSE19899_A2 | Down | -0.1520681435 |
| PubMed_21979375_A1 | Up | 0.0835466428 |
| PubMed_21979375_A2 | Down | -0.1907360007 |
| GSE35957 | Up | 0.0867735663 |
| GSE36640 | Down | -0.3196186028 |
| GSE54402 | Up | 0.1235853192 |
| GSE9593 | Up | 0.0563527779 |
| GSE43922 | Down | -0.1290707804 |
| GSE24585 | Up | 0.4717680515 |
| GSE37065 | Up | 0.2106875608 |
| GSE28863_A1 | Up | 0.7199624689 |
| GSE28863_A2 | Up | 0.5403122588 |
| GSE28863_A3 | Down | -0.1116999553 |
| GSE28863_A4 | Up | 0.0271297210 |
| GSE48662 | Up | 0.3339967613 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| N-(5-{[(2S)-4-amino-2-(3-chlorophenyl)butanoyl]amino}-1H-indazol-3-yl)benzamide | DB07608 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017031 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024657 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-148a-3p | MIMAT0000243 | MIRT026006 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026227 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-324-5p | MIMAT0000761 | MIRT043199 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-99b-5p | MIMAT0000689 | MIRT044178 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049774 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-199b-5p | MIMAT0000263 | NA | hsa-miR-199b-5p | 21102440 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
