HCSGD entry for AGTR1
1. General information
| Official gene symbol | AGTR1 |
|---|---|
| Entrez ID | 185 |
| Gene full name | angiotensin II receptor, type 1 |
| Other gene symbols | AG2S AGTR1A AGTR1B AT1 AT1AR AT1B AT1BR AT1R AT2R1 AT2R1A AT2R1B HAT1R |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001558 | Regulation of cell growth | NAS | biological_process |
| GO:0001596 | Angiotensin type I receptor activity | IDA IPI | molecular_function |
| GO:0001822 | Kidney development | IMP | biological_process |
| GO:0002018 | Renin-angiotensin regulation of aldosterone production | NAS | biological_process |
| GO:0002034 | Regulation of blood vessel size by renin-angiotensin | IC | biological_process |
| GO:0003081 | Regulation of systemic arterial blood pressure by renin-angiotensin | IC | biological_process |
| GO:0004945 | Angiotensin type II receptor activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005886 | Plasma membrane | IDA TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | IC | cellular_component |
| GO:0007186 | G-protein coupled receptor signaling pathway | IDA | biological_process |
| GO:0007200 | Phospholipase C-activating G-protein coupled receptor signaling pathway | NAS | biological_process |
| GO:0007204 | Positive regulation of cytosolic calcium ion concentration | IDA | biological_process |
| GO:0007266 | Rho protein signal transduction | IDA | biological_process |
| GO:0010744 | Positive regulation of macrophage derived foam cell differentiation | IC | biological_process |
| GO:0010873 | Positive regulation of cholesterol esterification | IMP | biological_process |
| GO:0016021 | Integral component of membrane | NAS | cellular_component |
| GO:0019229 | Regulation of vasoconstriction | IC IDA NAS | biological_process |
| GO:0019722 | Calcium-mediated signaling | IDA | biological_process |
| GO:0031711 | Bradykinin receptor binding | IPI | molecular_function |
| GO:0032270 | Positive regulation of cellular protein metabolic process | IMP | biological_process |
| GO:0032430 | Positive regulation of phospholipase A2 activity | IMP | biological_process |
| GO:0033864 | Positive regulation of NAD(P)H oxidase activity | TAS | biological_process |
| GO:0034374 | Low-density lipoprotein particle remodeling | NAS | biological_process |
| GO:0035813 | Regulation of renal sodium excretion | NAS | biological_process |
| GO:0038166 | Angiotensin-activated signaling pathway | IDA IPI | biological_process |
| GO:0042127 | Regulation of cell proliferation | NAS | biological_process |
| GO:0042312 | Regulation of vasodilation | IC | biological_process |
| GO:0046982 | Protein heterodimerization activity | IPI | molecular_function |
| GO:0050727 | Regulation of inflammatory response | IC | biological_process |
| GO:0050729 | Positive regulation of inflammatory response | TAS | biological_process |
| GO:0051482 | Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway | IDA | biological_process |
| GO:0060326 | Cell chemotaxis | IDA | biological_process |
| GO:0086097 | Phospholipase C-activating angiotensin-activated signaling pathway | IDA IPI | biological_process |
| GO:2000379 | Positive regulation of reactive oxygen species metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0083371452 | 0.6110016527 | 0.2362131324 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.4053329367 |
| GSE13712_SHEAR | Up | 0.0515250376 |
| GSE13712_STATIC | Up | 0.0296768733 |
| GSE19018 | Down | -0.4904099612 |
| GSE19899_A1 | Up | 0.3875881072 |
| GSE19899_A2 | Up | 2.8472629351 |
| PubMed_21979375_A1 | Up | 0.5707562744 |
| PubMed_21979375_A2 | Up | 0.3019890630 |
| GSE35957 | Down | -0.3263649605 |
| GSE36640 | Down | -1.0248805908 |
| GSE54402 | Up | 1.9513411513 |
| GSE9593 | Up | 0.6203035820 |
| GSE43922 | Up | 0.8357427367 |
| GSE24585 | Up | 0.6782017421 |
| GSE37065 | Up | 0.2527927733 |
| GSE28863_A1 | Up | 0.0682029663 |
| GSE28863_A2 | Down | -0.2953828147 |
| GSE28863_A3 | Down | -0.0312837247 |
| GSE28863_A4 | Up | 0.0297729762 |
| GSE48662 | Down | -0.4277814086 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| Valsartan | DB00177 | APRD00133 |
| Olmesartan | DB00275 | APRD00223 |
| Losartan | DB00678 | APRD00052 |
| Irbesartan | DB01029 | APRD00413 |
| Forasartan | DB01342 | - |
| Saprisartan | DB01347 | - |
| Tasosartan | DB01349 | - |
| CYT006-AngQb | DB05739 | - |
| Azilsartan medoxomil | DB08822 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | MIRT002006 | Luciferase reporter assay//Reporter assay | Functional MTI | 17668390 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT002006 | Luciferase reporter assay | Functional MTI | 19177201 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT002006 | Luciferase reporter assay//Real time PCR//Reporter assay | Functional MTI | 17588946 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT002006 | Luciferase reporter assay//qRT-PCR//Quantitative proteomic approach//Western blot | Functional MTI | 20735984 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT002006 | Luciferase reporter assay//qRT-PCR//Western blot//Reporter assay | Functional MTI | 16675453 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT002006 | Western blot | Functional MTI | 21310411 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT023107 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT030131 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | 1 | hsa-miR-155 | {radioreceptor binding assays} | {overexpression by miRNA precursor transfection} | 16675453 | |
| hsa-miR-155-5p | MIMAT0000646 | 1 | hsa-miR-155 | 17588946 | |||
| hsa-miR-155-5p | MIMAT0000646 | NA | hsa-miR-155 | 17668390 | |||
| hsa-miR-802 | MIMAT0004185 | 1 | hsa-miR-802 | {Western blot} | {overexpression by miRNA mimics tranfection} | 20558762 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22283774 | Activation of the classic RAS, ACE/Ang II/AT1R, has been strictly related to down regulation of pro-survival genes (Nampt and Sirt3), increase in ROS production and pro-inflammatory cytokines and chemokines release, leading to cell senescence, inflammation and development of autoimmune dysfunctions |
| 19777843 | Western blot were used to analyse protein expression of NADPH oxidase p47phox, angiotensin type 1 and 2 receptor (AT1R, AT2R) |
| 19777843 | Protein expression of p47phox, AT1R and AT2R in cells increased compared with Vit E group |
| 19777843 | Protein expression of p47phox, AT1R and AT2R in cells treated with Chinese herbs of high dose and low dose were decreased compared with Vit E group |
| 18633188 | Both reverse transcription-polymerase chain reaction (RT-PCR) and Western blotting were used to assess gp91phox expression and angiotensin type 1 receptor (AT1R) levels |
| 18633188 | Interestingly, pioglitazone decreased the expressions of AT1R mRNA and protein |
| 18633188 | In conclusion, pioglitazone inhibited Ang II-induced senescence of EPCs via down-regulation of the expression of AT1R |
| 16097371 | Both reverse transcription (RT)-polymerase chain reaction (PCR) and Western blotting were used to assess gp91phox and angiotensin type 1 receptor (AT1R) expression |
| 16097371 | Because we previously demonstrated that both the up-regulation of gp91phox and the acceleration of cellular senescence in Ang II-stimulated EPCs could be abolished by pre-treatment with the AT1R- specific antagonist, valsartan, we also explored the effect of estrogen on AT1R expression |
| 16097371 | In conclusion, estrogen reduces Ang II-induced acceleration of senescence in EPCs partially through down-regulation of AT1R expression |
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