HCSGD entry for DUSP3

1. General information

Official gene symbolDUSP3
Entrez ID1845
Gene full namedual specificity phosphatase 3
Other gene symbolsVHR
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000188Inactivation of MAPK activityIMPbiological_process
GO:0001701In utero embryonic developmentIEAbiological_process
GO:0001772Immunological synapseIDAcellular_component
GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0002756MyD88-independent toll-like receptor signaling pathwayTASbiological_process
GO:0004725Protein tyrosine phosphatase activityIDA IEAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005829CytosolIDAcellular_component
GO:0006470Protein dephosphorylationIEAbiological_process
GO:0008138Protein tyrosine/serine/threonine phosphatase activityIDA IEA IMPmolecular_function
GO:0033549MAP kinase phosphatase activityIMPmolecular_function
GO:0034134Toll-like receptor 2 signaling pathwayTASbiological_process
GO:0034138Toll-like receptor 3 signaling pathwayTASbiological_process
GO:0034142Toll-like receptor 4 signaling pathwayTASbiological_process
GO:0034146Toll-like receptor 5 signaling pathwayTASbiological_process
GO:0034162Toll-like receptor 9 signaling pathwayTASbiological_process
GO:0034166Toll-like receptor 10 signaling pathwayTASbiological_process
GO:0035335Peptidyl-tyrosine dephosphorylationIDAbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0038123Toll-like receptor TLR1:TLR2 signaling pathwayTASbiological_process
GO:0038124Toll-like receptor TLR6:TLR2 signaling pathwayTASbiological_process
GO:0043409Negative regulation of MAPK cascadeIMPbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045931Positive regulation of mitotic cell cycleIMPbiological_process
GO:0046329Negative regulation of JNK cascadeIDA IMPbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0050860Negative regulation of T cell receptor signaling pathwayIDAbiological_process
GO:0050868Negative regulation of T cell activationIDAbiological_process
GO:0051403Stress-activated MAPK cascadeTASbiological_process
GO:0070373Negative regulation of ERK1 and ERK2 cascadeIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00138031610.86971586190.10008622591.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.4397986288
GSE13712_SHEARUp0.3885764145
GSE13712_STATICUp0.0748393634
GSE19018Up0.0862405976
GSE19899_A1Up1.2533004498
GSE19899_A2Up2.4838309954
PubMed_21979375_A1Up0.7161289444
PubMed_21979375_A2Up2.0017778266
GSE35957Down-0.2950348405
GSE36640Up1.3473602899
GSE54402Up1.0920619440
GSE9593Up0.8752433408
GSE43922Up0.4246568880
GSE24585Down-0.0052087197
GSE37065Up0.1107638146
GSE28863_A1Down-0.6797546414
GSE28863_A2Up0.5171182037
GSE28863_A3Down-1.0436308559
GSE28863_A4Up0.2148778206
GSE48662Down-0.0006176582

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-361-5pMIMAT0000703MIRT020096SequencingFunctional MTI (Weak)20371350
hsa-miR-125a-5pMIMAT0000443MIRT021310SequencingFunctional MTI (Weak)20371350
hsa-miR-10a-5pMIMAT0000253MIRT025606SequencingFunctional MTI (Weak)20371350
hsa-miR-421MIMAT0003339MIRT039365CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

18505570Cervix carcinoma is associated with an up-regulation and nuclear localization of the dual-specificity protein phosphatase VHR
18505570BACKGROUND: The 21-kDa Vaccinia virus VH1-related (VHR) dual-specific protein phosphatase (encoded by the DUSP3 gene) plays a critical role in cell cycle progression and is itself regulated during the cell cycle
18505570We have previously demonstrated using RNA interference that cells lacking VHR arrest in the G1 and G2 phases of the cell cycle and show signs of beginning of cell senescence
18505570METHODS: In this report, we evaluated successfully the expression levels of VHR protein in 62 hysterectomy or conization specimens showing the various (pre) neoplastic cervical epithelial lesions and 35 additional cases of hysterectomy performed for non-cervical pathologies, from patients under 50 years of age
18505570We used a tissue microarray and IHC technique to evaluate the expression of the VHR phosphatase
18505570Immunofluorescence staining under confocal microscopy, Western blotting and RT-PCR methods were used to investigate the localization and expression levels of VHR
18505570In the invasive cancer, VHR is also highly expressed with nuclear localization in the majority of cells compared to normal tissue where VHR is always in the cytoplasm
18505570The immunofluorescence technique under confocal microscopy shows that VHR has a cytoplasmic localization in primary keratinocytes, while it localizes in both cytoplasm and nucleus of the cancer cell lines investigated
18505570We report that the up-regulation of this phosphatase is mainly due to its post-translational stabilization in the cancer cell lines compared to primary keratinocytes rather than increases in the transcription of DUSP3 locus
18505570CONCLUSION: These results together suggest that VHR can be considered as a new marker for cancer progression in cervix carcinoma and potential new target for anticancer therapy
17658517Cells were induced to senescence by inhibition of phosphatase activity (VHR, MKP3, or PP2A) without additional cellular stress
17012840Regulation of MAP kinases by the VHR dual-specific phosphatase: implications for cell growth and differentiation
17012840We recently found that the expression of the 21-kDa human Vaccinia H1-related (VHR) dual-specific phosphatase fluctuates during cell cycle progression and affects Erk and Jnk activity in a cell cycle-dependent manner
17012840Cells lacking VHR arrested at the G(1)/S and G(2)/M transitions of the cell cycle and exhibited senescence phenotypes
17012840Cells lacking VHR upregulated p21(Cip/Waf1) and downregulated many genes for cell cycle regulators, DNA replication, transcription, and mRNA processing
17012840In the absence of VHR, the serum-induced activation of Jnk and Erk was further elevated and was required for the G(1)/S and G(2)/M blocks, which were attenuated upon Jnk and Erk inhibition
17012840Collectively, VHR provides a long sought layer in the regulation of Jnk and Erk during cell cycle progression thereby contributing to cell cycle arrest, differentiation or senescence
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