HCSGD entry for DUSP1

1. General information

Official gene symbolDUSP1
Entrez ID1843
Gene full namedual specificity phosphatase 1
Other gene symbolsCL100 HVH1 MKP-1 MKP1 PTPN10
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000188Inactivation of MAPK activityIBA ISSbiological_process
GO:0001706Endoderm formationIBAbiological_process
GO:0004726Non-membrane spanning protein tyrosine phosphatase activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmIBAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0006470Protein dephosphorylationIBAbiological_process
GO:0006979Response to oxidative stressTASbiological_process
GO:0008330Protein tyrosine/threonine phosphatase activityIEAmolecular_function
GO:0009416Response to light stimulusIEAbiological_process
GO:0017017MAP kinase tyrosine/serine/threonine phosphatase activityIBA ISSmolecular_function
GO:0032355Response to estradiolIEAbiological_process
GO:0032526Response to retinoic acidIEAbiological_process
GO:0032870Cellular response to hormone stimulusIEAbiological_process
GO:0033574Response to testosteroneIEAbiological_process
GO:0035335Peptidyl-tyrosine dephosphorylationTASbiological_process
GO:0035556Intracellular signal transductionIEAbiological_process
GO:0042542Response to hydrogen peroxideIEAbiological_process
GO:0042981Regulation of apoptotic processIBAbiological_process
GO:0043065Positive regulation of apoptotic processIEAbiological_process
GO:0043066Negative regulation of apoptotic processIEAbiological_process
GO:0043407Negative regulation of MAP kinase activityIDAbiological_process
GO:0043409Negative regulation of MAPK cascadeISSbiological_process
GO:0051384Response to glucocorticoidIEAbiological_process
GO:0051447Negative regulation of meiotic cell cycleISSbiological_process
GO:0051591Response to cAMPIEAbiological_process
GO:0051592Response to calcium ionIEAbiological_process
GO:0071850Mitotic cell cycle arrestISSbiological_process
GO:0090266Regulation of mitotic cell cycle spindle assembly checkpointISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.02390068770.11704651040.36638905070.6566029838

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-1.1164090462
GSE13712_SHEARUp0.6668220781
GSE13712_STATICUp0.6532568273
GSE19018Down-0.6449681381
GSE19899_A1Down-0.1367998181
GSE19899_A2Up0.1383266636
PubMed_21979375_A1Up0.8716446816
PubMed_21979375_A2Down-0.4833220158
GSE35957Up0.6928427236
GSE36640Up0.3497233152
GSE54402Up0.4947817937
GSE9593Up0.2974941335
GSE43922Up0.1574847982
GSE24585Up1.7339188485
GSE37065Up0.4976223380
GSE28863_A1Up0.2220981405
GSE28863_A2Down-0.5622011297
GSE28863_A3Down-0.7555961102
GSE28863_A4Down-0.3871869019
GSE48662Down-0.0430039408

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-101-3pMIMAT0000099MIRT005876Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI21068409
hsa-miR-26b-5pMIMAT0000083MIRT028795MicroarrayFunctional MTI (Weak)19088304
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24950189Notch1 positively regulated the expression of inhibitor of DNA binding 1 (Id1) and MAP kinase phosphatase 1 (MKP1), while MKP1 further up-regulated Id1 expression by inhibiting p38MAPK-induced protein degradation
23185405We have also quantified the transcripts of genes involved in the repair of oxidative DNA damage at telomeres (OGG1), telomere regulation and elongation (TERT), and in the response to biopsychological stress (FOS and DUSP1)
15574883In addition to DUSP1 and known p53 and E2F targets, a number of genes such as PHLDA1, NR4A3, and a novel splice variant of STAC were implicated in senescence
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