HCSGD entry for DSP
1. General information
| Official gene symbol | DSP |
|---|---|
| Entrez ID | 1832 |
| Gene full name | desmoplakin |
| Other gene symbols | DP DPI DPII |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001533 | Cornified envelope | IDA | cellular_component |
| GO:0002934 | Desmosome organization | ISS | biological_process |
| GO:0003223 | Ventricular compact myocardium morphogenesis | ISS | biological_process |
| GO:0005080 | Protein kinase C binding | IPI | molecular_function |
| GO:0005198 | Structural molecule activity | IDA | molecular_function |
| GO:0005200 | Structural constituent of cytoskeleton | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0005882 | Intermediate filament | ISS | cellular_component |
| GO:0005886 | Plasma membrane | IDA TAS | cellular_component |
| GO:0005916 | Fascia adherens | IEA | cellular_component |
| GO:0006915 | Apoptotic process | TAS | biological_process |
| GO:0006921 | Cellular component disassembly involved in execution phase of apoptosis | TAS | biological_process |
| GO:0008544 | Epidermis development | TAS | biological_process |
| GO:0014704 | Intercalated disc | IDA | cellular_component |
| GO:0016323 | Basolateral plasma membrane | IEA | cellular_component |
| GO:0016337 | Cell-cell adhesion | IEA | biological_process |
| GO:0018149 | Peptide cross-linking | IDA | biological_process |
| GO:0030057 | Desmosome | IEA | cellular_component |
| GO:0030216 | Keratinocyte differentiation | IDA | biological_process |
| GO:0030674 | Protein binding, bridging | IDA | molecular_function |
| GO:0034332 | Adherens junction organization | IEA | biological_process |
| GO:0042060 | Wound healing | IEA | biological_process |
| GO:0045109 | Intermediate filament organization | ISS | biological_process |
| GO:0050839 | Cell adhesion molecule binding | IEA | molecular_function |
| GO:0071896 | Protein localization to adherens junction | ISS | biological_process |
| GO:0086005 | Ventricular cardiac muscle cell action potential | IMP | biological_process |
| GO:0086069 | Bundle of His cell to Purkinje myocyte communication | IMP | biological_process |
| GO:0086091 | Regulation of heart rate by cardiac conduction | IMP | biological_process |
| GO:0097110 | Scaffold protein binding | IPI | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0145106759 | 0.0099018654 | 0.2990880971 | 0.1974996215 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0816954748 |
| GSE13712_SHEAR | Up | 0.0552258041 |
| GSE13712_STATIC | Up | 0.1281332309 |
| GSE19018 | Up | 1.8774674229 |
| GSE19899_A1 | Down | -0.7224550804 |
| GSE19899_A2 | Down | -0.8921662975 |
| PubMed_21979375_A1 | Down | -1.7917089250 |
| PubMed_21979375_A2 | Down | -1.6077115899 |
| GSE35957 | Up | 1.1803511849 |
| GSE36640 | Down | -0.5381085941 |
| GSE54402 | Down | -1.3209587206 |
| GSE9593 | Up | 3.7908446901 |
| GSE43922 | Down | -0.8318089194 |
| GSE24585 | Down | -0.1146167791 |
| GSE37065 | Up | 0.8658718787 |
| GSE28863_A1 | Up | 0.1250811240 |
| GSE28863_A2 | Up | 1.6007539984 |
| GSE28863_A3 | Down | -0.4128231586 |
| GSE28863_A4 | Down | -0.3802845786 |
| GSE48662 | Down | -0.0780080056 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-let-7b-5p | MIMAT0000063 | MIRT001637 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT001637 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-9-5p | MIMAT0000441 | MIRT021319 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025251 | Proteomics | Functional MTI (Weak) | 21566225 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031374 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT045149 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7e-5p | MIMAT0000066 | MIRT051650 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26118837 | Here we investigate the gene expression of different target genes related to cell death, namely programmed cell death 4 (PDCD4), tumor susceptibility gene 101 (TSG101), developmental and cell death (DCD) domain, death specific protein (DSP) and metacaspase (MC), using RT-qPCR in the cosmopolitan coastal centric diatom species Skeletonema marinoi, which contributes significantly to phytoplankton blooms in temperate waters |
| 26118837 | Results showed that DSP gene expression had a clear and constant increase along the S |
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