HCSGD entry for AGT


1. General information

Official gene symbolAGT
Entrez ID183
Gene full nameangiotensinogen (serpin peptidase inhibitor, clade A, member 8)
Other gene symbolsANHU SERPINA8
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001543Ovarian follicle ruptureIEAbiological_process
GO:0001558Regulation of cell growthNASbiological_process
GO:0001568Blood vessel developmentIEAbiological_process
GO:0001658Branching involved in ureteric bud morphogenesisIEAbiological_process
GO:0001819Positive regulation of cytokine productionTASbiological_process
GO:0001822Kidney developmentIMPbiological_process
GO:0001974Blood vessel remodelingTASbiological_process
GO:0001998Angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressureIEAbiological_process
GO:0001999Renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressureIEAbiological_process
GO:0002003Angiotensin maturationTASbiological_process
GO:0002016Regulation of blood volume by renin-angiotensinNASbiological_process
GO:0002018Renin-angiotensin regulation of aldosterone productionNASbiological_process
GO:0002019Regulation of renal output by angiotensinNASbiological_process
GO:0002034Regulation of blood vessel size by renin-angiotensinTASbiological_process
GO:0003051Angiotensin-mediated drinking behaviorIEAbiological_process
GO:0003331Positive regulation of extracellular matrix constituent secretionIEAbiological_process
GO:0004867Serine-type endopeptidase inhibitor activityIBAmolecular_function
GO:0005179Hormone activityIC ISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionNAS TAScellular_component
GO:0005615Extracellular spaceIC IDA ISScellular_component
GO:0006883Cellular sodium ion homeostasisIEAbiological_process
GO:0007160Cell-matrix adhesionIEAbiological_process
GO:0007186G-protein coupled receptor signaling pathwayIDAbiological_process
GO:0007199G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messengerTASbiological_process
GO:0007200Phospholipase C-activating G-protein coupled receptor signaling pathwayNASbiological_process
GO:0007202Activation of phospholipase C activityIEAbiological_process
GO:0007250Activation of NF-kappaB-inducing kinase activityIEAbiological_process
GO:0007263Nitric oxide mediated signal transductionTASbiological_process
GO:0007267Cell-cell signalingTASbiological_process
GO:0007568AgingIEAbiological_process
GO:0007588ExcretionIEAbiological_process
GO:0008065Establishment of blood-nerve barrierIEAbiological_process
GO:0008083Growth factor activityTASmolecular_function
GO:0008285Negative regulation of cell proliferationIEAbiological_process
GO:0009409Response to coldIEAbiological_process
GO:0009651Response to salt stressIEAbiological_process
GO:0010535Positive regulation of activation of JAK2 kinase activityIMPbiological_process
GO:0010595Positive regulation of endothelial cell migrationIDAbiological_process
GO:0010613Positive regulation of cardiac muscle hypertrophyISSbiological_process
GO:0010744Positive regulation of macrophage derived foam cell differentiationICbiological_process
GO:0010873Positive regulation of cholesterol esterificationIDAbiological_process
GO:0010951Negative regulation of endopeptidase activityIBAbiological_process
GO:0014061Regulation of norepinephrine secretionIEAbiological_process
GO:0014068Positive regulation of phosphatidylinositol 3-kinase signalingIDAbiological_process
GO:0014824Artery smooth muscle contractionIEAbiological_process
GO:0014873Response to muscle activity involved in regulation of muscle adaptationISSbiological_process
GO:0016525Negative regulation of angiogenesisIEAbiological_process
GO:0019229Regulation of vasoconstrictionNASbiological_process
GO:0030162Regulation of proteolysisIBAbiological_process
GO:0030198Extracellular matrix organizationIEAbiological_process
GO:0030308Negative regulation of cell growthIEAbiological_process
GO:0030432PeristalsisIEAbiological_process
GO:0031702Type 1 angiotensin receptor bindingIPImolecular_function
GO:0031703Type 2 angiotensin receptor bindingIPImolecular_function
GO:0032270Positive regulation of cellular protein metabolic processIDAbiological_process
GO:0032930Positive regulation of superoxide anion generationIEAbiological_process
GO:0033864Positive regulation of NAD(P)H oxidase activityTASbiological_process
GO:0034104Negative regulation of tissue remodelingIEAbiological_process
GO:0034374Low-density lipoprotein particle remodelingNASbiological_process
GO:0035411Catenin import into nucleusIEAbiological_process
GO:0035813Regulation of renal sodium excretionNASbiological_process
GO:0035815Positive regulation of renal sodium excretionIEAbiological_process
GO:0040018Positive regulation of multicellular organism growthIEAbiological_process
GO:0042127Regulation of cell proliferationNASbiological_process
GO:0042311VasodilationIEAbiological_process
GO:0043410Positive regulation of MAPK cascadeIEAbiological_process
GO:0043524Negative regulation of neuron apoptotic processIEAbiological_process
GO:0044255Cellular lipid metabolic processTASbiological_process
GO:0044267Cellular protein metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045723Positive regulation of fatty acid biosynthetic processIEAbiological_process
GO:0045742Positive regulation of epidermal growth factor receptor signaling pathwayIDAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDAbiological_process
GO:0046622Positive regulation of organ growthIEAbiological_process
GO:0048143Astrocyte activationIEAbiological_process
GO:0048144Fibroblast proliferationIEAbiological_process
GO:0048146Positive regulation of fibroblast proliferationISSbiological_process
GO:0048169Regulation of long-term neuronal synaptic plasticityIEAbiological_process
GO:0048659Smooth muscle cell proliferationIEAbiological_process
GO:0050663Cytokine secretionIEAbiological_process
GO:0050729Positive regulation of inflammatory responseTASbiological_process
GO:0050731Positive regulation of peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0051092Positive regulation of NF-kappaB transcription factor activityTASbiological_process
GO:0051145Smooth muscle cell differentiationIEAbiological_process
GO:0051387Negative regulation of neurotrophin TRK receptor signaling pathwayIDAbiological_process
GO:0051403Stress-activated MAPK cascadeIEAbiological_process
GO:0051924Regulation of calcium ion transportIEAbiological_process
GO:0061049Cell growth involved in cardiac muscle cell developmentIEAbiological_process
GO:0061098Positive regulation of protein tyrosine kinase activityIMPbiological_process
GO:0070371ERK1 and ERK2 cascadeIEAbiological_process
GO:0070471Uterine smooth muscle contractionIEAbiological_process
GO:0071260Cellular response to mechanical stimulusIEAbiological_process
GO:0090190Positive regulation of branching involved in ureteric bud morphogenesisIDAbiological_process
GO:2000379Positive regulation of reactive oxygen species metabolic processTASbiological_process
GO:2001238Positive regulation of extrinsic apoptotic signaling pathwayIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.09004364580.54044293530.63066492821.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0379193732
GSE13712_SHEARDown-0.1178252586
GSE13712_STATICDown-0.1696487738
GSE19018Down-0.2053380107
GSE19899_A1Up0.0396681740
GSE19899_A2Down-1.0220964029
PubMed_21979375_A1Down-0.5830482251
PubMed_21979375_A2Up0.0874056620
GSE35957Up0.5073629780
GSE36640Up0.9096974102
GSE54402Down-0.0713047988
GSE9593Up0.5662278840
GSE43922Up0.0414860419
GSE24585Up0.0245831896
GSE37065Up0.3018813709
GSE28863_A1Up0.0178164347
GSE28863_A2Up0.6696882917
GSE28863_A3Up0.1106150156
GSE28863_A4Up0.0709704607
GSE48662Up0.8290201186

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

PS433540DB05206 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT028917MicroarrayFunctional MTI (Weak)19088304
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

18716376In endothelial cells, IP-10 significantly increased mRNA expression of renin, angiotensin-converting enzyme, and angiotensinogen
18716376Angiotensin II significantly increased mRNA expression of renin, angiotensin converting enzyme and angiotensinogen, which was blocked by neutralization of IP-10 with antibody in endothelial cells
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