HCSGD entry for AGT
1. General information
Official gene symbol | AGT |
---|---|
Entrez ID | 183 |
Gene full name | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) |
Other gene symbols | ANHU SERPINA8 |
Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
---|---|---|---|
GO:0001543 | Ovarian follicle rupture | IEA | biological_process |
GO:0001558 | Regulation of cell growth | NAS | biological_process |
GO:0001568 | Blood vessel development | IEA | biological_process |
GO:0001658 | Branching involved in ureteric bud morphogenesis | IEA | biological_process |
GO:0001819 | Positive regulation of cytokine production | TAS | biological_process |
GO:0001822 | Kidney development | IMP | biological_process |
GO:0001974 | Blood vessel remodeling | TAS | biological_process |
GO:0001998 | Angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure | IEA | biological_process |
GO:0001999 | Renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure | IEA | biological_process |
GO:0002003 | Angiotensin maturation | TAS | biological_process |
GO:0002016 | Regulation of blood volume by renin-angiotensin | NAS | biological_process |
GO:0002018 | Renin-angiotensin regulation of aldosterone production | NAS | biological_process |
GO:0002019 | Regulation of renal output by angiotensin | NAS | biological_process |
GO:0002034 | Regulation of blood vessel size by renin-angiotensin | TAS | biological_process |
GO:0003051 | Angiotensin-mediated drinking behavior | IEA | biological_process |
GO:0003331 | Positive regulation of extracellular matrix constituent secretion | IEA | biological_process |
GO:0004867 | Serine-type endopeptidase inhibitor activity | IBA | molecular_function |
GO:0005179 | Hormone activity | IC ISS | molecular_function |
GO:0005515 | Protein binding | IPI | molecular_function |
GO:0005576 | Extracellular region | NAS TAS | cellular_component |
GO:0005615 | Extracellular space | IC IDA ISS | cellular_component |
GO:0006883 | Cellular sodium ion homeostasis | IEA | biological_process |
GO:0007160 | Cell-matrix adhesion | IEA | biological_process |
GO:0007186 | G-protein coupled receptor signaling pathway | IDA | biological_process |
GO:0007199 | G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger | TAS | biological_process |
GO:0007200 | Phospholipase C-activating G-protein coupled receptor signaling pathway | NAS | biological_process |
GO:0007202 | Activation of phospholipase C activity | IEA | biological_process |
GO:0007250 | Activation of NF-kappaB-inducing kinase activity | IEA | biological_process |
GO:0007263 | Nitric oxide mediated signal transduction | TAS | biological_process |
GO:0007267 | Cell-cell signaling | TAS | biological_process |
GO:0007568 | Aging | IEA | biological_process |
GO:0007588 | Excretion | IEA | biological_process |
GO:0008065 | Establishment of blood-nerve barrier | IEA | biological_process |
GO:0008083 | Growth factor activity | TAS | molecular_function |
GO:0008285 | Negative regulation of cell proliferation | IEA | biological_process |
GO:0009409 | Response to cold | IEA | biological_process |
GO:0009651 | Response to salt stress | IEA | biological_process |
GO:0010535 | Positive regulation of activation of JAK2 kinase activity | IMP | biological_process |
GO:0010595 | Positive regulation of endothelial cell migration | IDA | biological_process |
GO:0010613 | Positive regulation of cardiac muscle hypertrophy | ISS | biological_process |
GO:0010744 | Positive regulation of macrophage derived foam cell differentiation | IC | biological_process |
GO:0010873 | Positive regulation of cholesterol esterification | IDA | biological_process |
GO:0010951 | Negative regulation of endopeptidase activity | IBA | biological_process |
GO:0014061 | Regulation of norepinephrine secretion | IEA | biological_process |
GO:0014068 | Positive regulation of phosphatidylinositol 3-kinase signaling | IDA | biological_process |
GO:0014824 | Artery smooth muscle contraction | IEA | biological_process |
GO:0014873 | Response to muscle activity involved in regulation of muscle adaptation | ISS | biological_process |
GO:0016525 | Negative regulation of angiogenesis | IEA | biological_process |
GO:0019229 | Regulation of vasoconstriction | NAS | biological_process |
GO:0030162 | Regulation of proteolysis | IBA | biological_process |
GO:0030198 | Extracellular matrix organization | IEA | biological_process |
GO:0030308 | Negative regulation of cell growth | IEA | biological_process |
GO:0030432 | Peristalsis | IEA | biological_process |
GO:0031702 | Type 1 angiotensin receptor binding | IPI | molecular_function |
GO:0031703 | Type 2 angiotensin receptor binding | IPI | molecular_function |
GO:0032270 | Positive regulation of cellular protein metabolic process | IDA | biological_process |
GO:0032930 | Positive regulation of superoxide anion generation | IEA | biological_process |
GO:0033864 | Positive regulation of NAD(P)H oxidase activity | TAS | biological_process |
GO:0034104 | Negative regulation of tissue remodeling | IEA | biological_process |
GO:0034374 | Low-density lipoprotein particle remodeling | NAS | biological_process |
GO:0035411 | Catenin import into nucleus | IEA | biological_process |
GO:0035813 | Regulation of renal sodium excretion | NAS | biological_process |
GO:0035815 | Positive regulation of renal sodium excretion | IEA | biological_process |
GO:0040018 | Positive regulation of multicellular organism growth | IEA | biological_process |
GO:0042127 | Regulation of cell proliferation | NAS | biological_process |
GO:0042311 | Vasodilation | IEA | biological_process |
GO:0043410 | Positive regulation of MAPK cascade | IEA | biological_process |
GO:0043524 | Negative regulation of neuron apoptotic process | IEA | biological_process |
GO:0044255 | Cellular lipid metabolic process | TAS | biological_process |
GO:0044267 | Cellular protein metabolic process | TAS | biological_process |
GO:0044281 | Small molecule metabolic process | TAS | biological_process |
GO:0045723 | Positive regulation of fatty acid biosynthetic process | IEA | biological_process |
GO:0045742 | Positive regulation of epidermal growth factor receptor signaling pathway | IDA | biological_process |
GO:0045893 | Positive regulation of transcription, DNA-templated | IDA | biological_process |
GO:0046622 | Positive regulation of organ growth | IEA | biological_process |
GO:0048143 | Astrocyte activation | IEA | biological_process |
GO:0048144 | Fibroblast proliferation | IEA | biological_process |
GO:0048146 | Positive regulation of fibroblast proliferation | ISS | biological_process |
GO:0048169 | Regulation of long-term neuronal synaptic plasticity | IEA | biological_process |
GO:0048659 | Smooth muscle cell proliferation | IEA | biological_process |
GO:0050663 | Cytokine secretion | IEA | biological_process |
GO:0050729 | Positive regulation of inflammatory response | TAS | biological_process |
GO:0050731 | Positive regulation of peptidyl-tyrosine phosphorylation | IDA | biological_process |
GO:0051092 | Positive regulation of NF-kappaB transcription factor activity | TAS | biological_process |
GO:0051145 | Smooth muscle cell differentiation | IEA | biological_process |
GO:0051387 | Negative regulation of neurotrophin TRK receptor signaling pathway | IDA | biological_process |
GO:0051403 | Stress-activated MAPK cascade | IEA | biological_process |
GO:0051924 | Regulation of calcium ion transport | IEA | biological_process |
GO:0061049 | Cell growth involved in cardiac muscle cell development | IEA | biological_process |
GO:0061098 | Positive regulation of protein tyrosine kinase activity | IMP | biological_process |
GO:0070371 | ERK1 and ERK2 cascade | IEA | biological_process |
GO:0070471 | Uterine smooth muscle contraction | IEA | biological_process |
GO:0071260 | Cellular response to mechanical stimulus | IEA | biological_process |
GO:0090190 | Positive regulation of branching involved in ureteric bud morphogenesis | IDA | biological_process |
GO:2000379 | Positive regulation of reactive oxygen species metabolic process | TAS | biological_process |
GO:2001238 | Positive regulation of extrinsic apoptotic signaling pathway | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
p-value up | p-value down | FDR up | FDR down |
---|---|---|---|
0.0900436458 | 0.5404429353 | 0.6306649282 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
Data source | Up or down | Log fold change |
---|---|---|
GSE11954 | Up | 0.0379193732 |
GSE13712_SHEAR | Down | -0.1178252586 |
GSE13712_STATIC | Down | -0.1696487738 |
GSE19018 | Down | -0.2053380107 |
GSE19899_A1 | Up | 0.0396681740 |
GSE19899_A2 | Down | -1.0220964029 |
PubMed_21979375_A1 | Down | -0.5830482251 |
PubMed_21979375_A2 | Up | 0.0874056620 |
GSE35957 | Up | 0.5073629780 |
GSE36640 | Up | 0.9096974102 |
GSE54402 | Down | -0.0713047988 |
GSE9593 | Up | 0.5662278840 |
GSE43922 | Up | 0.0414860419 |
GSE24585 | Up | 0.0245831896 |
GSE37065 | Up | 0.3018813709 |
GSE28863_A1 | Up | 0.0178164347 |
GSE28863_A2 | Up | 0.6696882917 |
GSE28863_A3 | Up | 0.1106150156 |
GSE28863_A4 | Up | 0.0709704607 |
GSE48662 | Up | 0.8290201186 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
---|---|---|
PS433540 | DB05206 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
---|---|---|---|---|---|
hsa-miR-26b-5p | MIMAT0000083 | MIRT028917 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
---|---|
18716376 | In endothelial cells, IP-10 significantly increased mRNA expression of renin, angiotensin-converting enzyme, and angiotensinogen |
18716376 | Angiotensin II significantly increased mRNA expression of renin, angiotensin converting enzyme and angiotensinogen, which was blocked by neutralization of IP-10 with antibody in endothelial cells |
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