HCSGD entry for DSG2
1. General information
| Official gene symbol | DSG2 |
|---|---|
| Entrez ID | 1829 |
| Gene full name | desmoglein 2 |
| Other gene symbols | ARVC10 ARVD10 CDHF5 CMD1BB HDGC |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005509 | Calcium ion binding | IEA | molecular_function |
| GO:0005886 | Plasma membrane | IDA IEA TAS | cellular_component |
| GO:0005911 | Cell-cell junction | TAS | cellular_component |
| GO:0006915 | Apoptotic process | TAS | biological_process |
| GO:0006921 | Cellular component disassembly involved in execution phase of apoptosis | TAS | biological_process |
| GO:0007155 | Cell adhesion | IDA | biological_process |
| GO:0007156 | Homophilic cell adhesion | IEA | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016324 | Apical plasma membrane | IEA | cellular_component |
| GO:0016328 | Lateral plasma membrane | IEA | cellular_component |
| GO:0030057 | Desmosome | IEA | cellular_component |
| GO:0032570 | Response to progesterone | IEA | biological_process |
| GO:0060135 | Maternal process involved in female pregnancy | IEA | biological_process |
| GO:0086005 | Ventricular cardiac muscle cell action potential | IMP | biological_process |
| GO:0086069 | Bundle of His cell to Purkinje myocyte communication | IMP | biological_process |
| GO:0086091 | Regulation of heart rate by cardiac conduction | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9736764029 | 0.0015572661 | 0.9999902473 | 0.0760460111 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -1.4581078527 |
| GSE13712_SHEAR | Down | -0.0776067770 |
| GSE13712_STATIC | Up | 0.0994911467 |
| GSE19018 | Up | 0.1020500389 |
| GSE19899_A1 | Down | -0.2292607758 |
| GSE19899_A2 | Down | -2.6174440787 |
| PubMed_21979375_A1 | Down | -1.1058966272 |
| PubMed_21979375_A2 | Down | -1.4945295233 |
| GSE35957 | Down | -1.5636783278 |
| GSE36640 | Down | -4.0174293151 |
| GSE54402 | Down | -1.9392389084 |
| GSE9593 | Down | -0.0134824336 |
| GSE43922 | Down | -0.8900416744 |
| GSE24585 | Up | 0.1429564117 |
| GSE37065 | Up | 0.7426298484 |
| GSE28863_A1 | Down | -0.2552335887 |
| GSE28863_A2 | Down | -0.1860213130 |
| GSE28863_A3 | Up | 0.2376904628 |
| GSE28863_A4 | Down | -0.0713311224 |
| GSE48662 | Down | -0.0977307289 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | MIRT001550 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT022526 | Proteomics;Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-1 | MIMAT0000416 | MIRT023688 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-1 | MIMAT0000416 | MIRT023688 | Proteomics;Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-30a-5p | MIMAT0000087 | MIRT028541 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT032265 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-15b-5p | MIMAT0000417 | MIRT046436 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
