HCSGD entry for ARID3A
1. General information
| Official gene symbol | ARID3A |
|---|---|
| Entrez ID | 1820 |
| Gene full name | AT rich interactive domain 3A (BRIGHT-like) |
| Other gene symbols | BRIGHT DRIL1 DRIL3 E2FBP1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003682 | Chromatin binding | IEA | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0042803 | Protein homodimerization activity | IEA | molecular_function |
| GO:0045121 | Membrane raft | IDA | cellular_component |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1163766270 | 0.8875627598 | 0.7001690237 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1298671824 |
| GSE13712_SHEAR | Up | 0.2065244889 |
| GSE13712_STATIC | Up | 0.7000379341 |
| GSE19018 | Up | 0.0199970773 |
| GSE19899_A1 | Down | -0.1733709275 |
| GSE19899_A2 | Up | 0.5276112266 |
| PubMed_21979375_A1 | Up | 0.5954073634 |
| PubMed_21979375_A2 | Up | 0.6735966088 |
| GSE35957 | Down | -0.0904385316 |
| GSE36640 | Down | -0.3563243857 |
| GSE54402 | Down | -0.1010179675 |
| GSE9593 | Down | -0.0829345252 |
| GSE43922 | Up | 0.0469164503 |
| GSE24585 | Up | 0.2852509589 |
| GSE37065 | Up | 0.0382629729 |
| GSE28863_A1 | Up | 0.1469210684 |
| GSE28863_A2 | Up | 0.1283572944 |
| GSE28863_A3 | Up | 0.3155714867 |
| GSE28863_A4 | Down | -0.0239058714 |
| GSE48662 | Up | 0.1391918824 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-let-7b-5p | MIMAT0000063 | MIRT005059 | Microarray | Functional MTI (Weak) | 17699775 |
| hsa-miR-30b-5p | MIMAT0000420 | MIRT023439 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-98-5p | MIMAT0000096 | MIRT027857 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-let-7d-5p | MIMAT0000065 | MIRT032173 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-484 | MIMAT0002174 | MIRT041956 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-425-3p | MIMAT0001343 | MIRT042421 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25931205 | Further analysis has provided data supporting this model, implicating Arid3a as a key transcription factor in mediating fetal-type B cell development |
| 22010578 | E2FBP1 antagonizes the p16(INK4A)-Rb tumor suppressor machinery for growth suppression and cellular senescence by regulating promyelocytic leukemia protein stability |
| 22010578 | E2F-binding protein 1 (E2FBP1), a transcription regulator for E2F, induces PML reduction and suppresses the formation of PML-nuclear bodies, whereas the down-regulation of E2FBP1 provokes the PML-dependent premature senescence in human normal fibroblasts |
| 22010578 | Here we report that the depletion of E2FBP1 induces the accumulation of PML through the Ras-dependent activation of MAP kinase signaling |
| 22010578 | The cellular levels of p16(INK4A) and p53 are elevated during premature senescence induced by depletion of E2FBP1, and the depletion of p16(INK4A), but not p53 rescued senescent cells from growth arrest |
| 22010578 | Similar to human normal fibroblasts, the growth inhibition induced by E2FBP1 depletion is also observed in human tumor cells with intact p16(INK4A) and Rb |
| 22010578 | These results suggest that E2FBP1 functions as a critical antagonist to the p16(INK4A)-Rb tumor suppressor machinery by regulating PML stability |
| 19436740 | SUMOylation of DRIL1 directs its transcriptional activity towards leukocyte lineage-specific genes |
| 19436740 | DRIL1 is an ARID family transcription factor that can immortalize primary mouse fibroblasts, bypass RAS(V12)-induced cellular senescence and collaborate with RAS(V12) or MYC in mediating oncogenic transformation |
| 19436740 | Little, however, is known about the regulation of DRIL1 activity |
| 19436740 | Recently, DRIL1 was found to interact with the SUMO-conjugating enzyme Ubc9, but the functional relevance of this association has not been assessed |
| 19436740 | Here, we show that DRIL1 is sumoylated both in vitro and in vivo at lysine 398 |
| 19436740 | Moreover, we provide evidence that PIASy functions as a specific SUMO E3-ligase for DRIL1 and promotes its sumoylation both in vitro and in vivo |
| 19436740 | Furthermore, consistent with the subnuclear localization of PIASy in the Matrix-Associated Region (MAR), SUMO-modified DRIL1 species are found exclusively in the MAR fraction |
| 19436740 | In contrast, DRIL1 sumoylation impairs its interaction with E2F1 in vitro and modifies its transcriptional activity in vivo, driving transcription of subset of genes regulating leukocyte fate |
| 19436740 | Taken together, these results identify sumoylation as a novel post-translational modification of DRIL1 that represents an important mechanism for targeting and modulating DRIL1 transcriptional activity |
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