HCSGD entry for DRD3

1. General information

Official gene symbolDRD3
Entrez ID1814
Gene full namedopamine receptor D3
Other gene symbolsD3DR ETM1 FET1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0001591Dopamine neurotransmitter receptor activity, coupled via Gi/GoIDA ISSmolecular_function
GO:0001963Synaptic transmission, dopaminergicIEAbiological_process
GO:0001975Response to amphetamineIEAbiological_process
GO:0002016Regulation of blood volume by renin-angiotensinIEAbiological_process
GO:0002031G-protein coupled receptor internalizationIDAbiological_process
GO:0004952Dopamine neurotransmitter receptor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005886Plasma membraneIDA TAScellular_component
GO:0005887Integral component of plasma membraneIC IDA IEAcellular_component
GO:0006874Cellular calcium ion homeostasisIDAbiological_process
GO:0007186G-protein coupled receptor signaling pathwayIDAbiological_process
GO:0007191Adenylate cyclase-activating dopamine receptor signaling pathwayIDAbiological_process
GO:0007194Negative regulation of adenylate cyclase activityIDAbiological_process
GO:0007195Adenylate cyclase-inhibiting dopamine receptor signaling pathwayIDA IEAbiological_process
GO:0007611Learning or memoryNASbiological_process
GO:0007612LearningNASbiological_process
GO:0007626Locomotory behaviorISSbiological_process
GO:0008144Drug bindingIDA ISSmolecular_function
GO:0008284Positive regulation of cell proliferationIEAbiological_process
GO:0008542Visual learningISSbiological_process
GO:0014059Regulation of dopamine secretionISSbiological_process
GO:0019216Regulation of lipid metabolic processIEAbiological_process
GO:0019904Protein domain specific bindingIEAmolecular_function
GO:0030139Endocytic vesicleIEAcellular_component
GO:0030814Regulation of cAMP metabolic processIDAbiological_process
GO:0031748D1 dopamine receptor bindingIEAmolecular_function
GO:0032416Negative regulation of sodium:hydrogen antiporter activityIEAbiological_process
GO:0032922Circadian regulation of gene expressionISSbiological_process
GO:0034776Response to histamineIDAbiological_process
GO:0035176Social behaviorNASbiological_process
GO:0035240Dopamine bindingIEAmolecular_function
GO:0035483Gastric emptyingIEAbiological_process
GO:0035815Positive regulation of renal sodium excretionIEAbiological_process
GO:0040014Regulation of multicellular organism growthIEAbiological_process
GO:0042220Response to cocaineIEPbiological_process
GO:0042417Dopamine metabolic processICbiological_process
GO:0042493Response to drugISSbiological_process
GO:0042995Cell projectionIEAcellular_component
GO:0043278Response to morphineISSbiological_process
GO:0045177Apical part of cellIEAcellular_component
GO:0045187Regulation of circadian sleep/wake cycle, sleepIEAbiological_process
GO:0045471Response to ethanolISSbiological_process
GO:0045776Negative regulation of blood pressureISSbiological_process
GO:0045840Positive regulation of mitosisISSbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0046717Acid secretionISSbiological_process
GO:0048148Behavioral response to cocaineIEP ISSbiological_process
GO:0048715Negative regulation of oligodendrocyte differentiationISSbiological_process
GO:0050482Arachidonic acid secretionIDAbiological_process
GO:0050709Negative regulation of protein secretionIDAbiological_process
GO:0050883Musculoskeletal movement, spinal reflex actionISSbiological_process
GO:0051584Regulation of dopamine uptake involved in synaptic transmissionICbiological_process
GO:0051898Negative regulation of protein kinase B signalingISSbiological_process
GO:0060134Prepulse inhibitionIMPbiological_process
GO:0060160Negative regulation of dopamine receptor signaling pathwayIEAbiological_process
GO:0060161Positive regulation of dopamine receptor signaling pathwayISSbiological_process
GO:0090325Regulation of locomotion involved in locomotory behaviorIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.76757894840.88392393150.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0501163189
GSE13712_SHEARUp0.0136861510
GSE13712_STATICDown-0.0977387365
GSE19018Up0.0302036995
GSE19899_A1Up0.0641555343
GSE19899_A2Down-0.0978271786
PubMed_21979375_A1Up0.2118270909
PubMed_21979375_A2Down-0.0467880483
GSE35957Up0.0747934402
GSE36640Up0.0311177536
GSE54402Down-0.0132603344
GSE9593Up0.0838887329
GSE43922Up0.0109513886
GSE24585Up0.0066105939
GSE37065Down-0.0899432058
GSE28863_A1Up0.0509037894
GSE28863_A2Up0.0464402135
GSE28863_A3Up0.1148031009
GSE28863_A4Up0.1346328049
GSE48662Up0.0534618839

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT029658MicroarrayFunctional MTI (Weak)19088304
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  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-let-7d-5pMIMAT0000065NAhsa-let-7d{Western blot}{overexpression}19703567
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.