HCSGD entry for DRD2

1. General information

Official gene symbol	DRD2
Entrez ID	1813
Gene full name	dopamine receptor D2
Other gene symbols	D2DR D2R
Links to Entrez Gene	Links to Entrez Gene

2. Neighbors in the network

This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID	GO term	Evidence	Category
GO:0001591	Dopamine neurotransmitter receptor activity, coupled via Gi/Go	IDA IEA	molecular_function
GO:0001659	Temperature homeostasis	IEA ISS	biological_process
GO:0001666	Response to hypoxia	IEA	biological_process
GO:0001669	Acrosomal vesicle	IEA	cellular_component
GO:0001963	Synaptic transmission, dopaminergic	IEA	biological_process
GO:0001975	Response to amphetamine	IEA ISS	biological_process
GO:0001976	Neurological system process involved in regulation of systemic arterial blood pressure	IEA ISS	biological_process
GO:0002027	Regulation of heart rate	IEA ISS	biological_process
GO:0002028	Regulation of sodium ion transport	IEA ISS	biological_process
GO:0002031	G-protein coupled receptor internalization	IEA	biological_process
GO:0002052	Positive regulation of neuroblast proliferation	IEA ISS	biological_process
GO:0002092	Positive regulation of receptor internalization	IEA	biological_process
GO:0004935	Adrenergic receptor activity	IEA	molecular_function
GO:0004952	Dopamine neurotransmitter receptor activity	IEA	molecular_function
GO:0005515	Protein binding	IPI	molecular_function
GO:0005886	Plasma membrane	TAS	cellular_component
GO:0005887	Integral component of plasma membrane	IC IDA IEA	cellular_component
GO:0006874	Cellular calcium ion homeostasis	IC	biological_process
GO:0007194	Negative regulation of adenylate cyclase activity	IDA IEA	biological_process
GO:0007195	Adenylate cyclase-inhibiting dopamine receptor signaling pathway	IDA IEA	biological_process
GO:0007268	Synaptic transmission	IDA	biological_process
GO:0007270	Neuron-neuron synaptic transmission	ISS	biological_process
GO:0007409	Axonogenesis	IEA ISS	biological_process
GO:0007416	Synapse assembly	IEA ISS	biological_process
GO:0007608	Sensory perception of smell	IEA ISS	biological_process
GO:0007616	Long-term memory	IEA	biological_process
GO:0007625	Grooming behavior	IEA	biological_process
GO:0007626	Locomotory behavior	ISS	biological_process
GO:0007628	Adult walking behavior	IEA ISS	biological_process
GO:0007631	Feeding behavior	IEA	biological_process
GO:0008104	Protein localization	IEA ISS	biological_process
GO:0008144	Drug binding	IDA IEA	molecular_function
GO:0008285	Negative regulation of cell proliferation	IEA ISS	biological_process
GO:0008306	Associative learning	ISS	biological_process
GO:0008542	Visual learning	IEA ISS	biological_process
GO:0009416	Response to light stimulus	ISS	biological_process
GO:0009636	Response to toxic substance	IEA	biological_process
GO:0010039	Response to iron ion	IEA	biological_process
GO:0014069	Postsynaptic density	IEA	cellular_component
GO:0014854	Response to inactivity	IEA	biological_process
GO:0015459	Potassium channel regulator activity	NAS	molecular_function
GO:0016055	Wnt signaling pathway	IEA	biological_process
GO:0016328	Lateral plasma membrane	IEA	cellular_component
GO:0021756	Striatum development	IEA	biological_process
GO:0021769	Orbitofrontal cortex development	IEA	biological_process
GO:0021853	Cerebral cortex GABAergic interneuron migration	IEA ISS	biological_process
GO:0021984	Adenohypophysis development	IEA ISS	biological_process
GO:0030139	Endocytic vesicle	IEA	cellular_component
GO:0030336	Negative regulation of cell migration	IEA ISS	biological_process
GO:0030424	Axon	ISS	cellular_component
GO:0030425	Dendrite	ISS	cellular_component
GO:0030432	Peristalsis	IEA ISS	biological_process
GO:0030672	Synaptic vesicle membrane	IEA	cellular_component
GO:0030814	Regulation of cAMP metabolic process	IDA	biological_process
GO:0031223	Auditory behavior	IEA	biological_process
GO:0032147	Activation of protein kinase activity	IEA	biological_process
GO:0032228	Regulation of synaptic transmission, GABAergic	IEA ISS	biological_process
GO:0032922	Circadian regulation of gene expression	IEA ISS	biological_process
GO:0033602	Negative regulation of dopamine secretion	IEA	biological_process
GO:0034776	Response to histamine	IDA	biological_process
GO:0035094	Response to nicotine	IEA	biological_process
GO:0035240	Dopamine binding	IEA	molecular_function
GO:0035255	Ionotropic glutamate receptor binding	IEA	molecular_function
GO:0035556	Intracellular signal transduction	IDA	biological_process
GO:0035810	Positive regulation of urine volume	IEA	biological_process
GO:0035815	Positive regulation of renal sodium excretion	IEA	biological_process
GO:0036126	Sperm flagellum	IEA	cellular_component
GO:0040018	Positive regulation of multicellular organism growth	IEA	biological_process
GO:0042220	Response to cocaine	ISS	biological_process
GO:0042321	Negative regulation of circadian sleep/wake cycle, sleep	IEA	biological_process
GO:0042417	Dopamine metabolic process	IC IEA	biological_process
GO:0042493	Response to drug	IEA ISS	biological_process
GO:0042802	Identical protein binding	IPI	molecular_function
GO:0042803	Protein homodimerization activity	IEA	molecular_function
GO:0043197	Dendritic spine	IEA	cellular_component
GO:0043204	Perikaryon	IEA	cellular_component
GO:0043266	Regulation of potassium ion transport	IEA ISS	biological_process
GO:0043278	Response to morphine	IEA ISS	biological_process
GO:0043473	Pigmentation	IEA	biological_process
GO:0043666	Regulation of phosphoprotein phosphatase activity	IEA	biological_process
GO:0043679	Axon terminus	IEA	cellular_component
GO:0045745	Positive regulation of G-protein coupled receptor protein signaling pathway	IEA	biological_process
GO:0045776	Negative regulation of blood pressure	IEA ISS	biological_process
GO:0045944	Positive regulation of transcription from RNA polymerase II promoter	IEA	biological_process
GO:0046488	Phosphatidylinositol metabolic process	IEA ISS	biological_process
GO:0046676	Negative regulation of insulin secretion	IEA	biological_process
GO:0046717	Acid secretion	IEA	biological_process
GO:0046982	Protein heterodimerization activity	IEA	molecular_function
GO:0048148	Behavioral response to cocaine	IEA ISS	biological_process
GO:0048149	Behavioral response to ethanol	IEA ISS	biological_process
GO:0048169	Regulation of long-term neuronal synaptic plasticity	IEA ISS	biological_process
GO:0048678	Response to axon injury	IEA	biological_process
GO:0048755	Branching morphogenesis of a nerve	IEA ISS	biological_process
GO:0050482	Arachidonic acid secretion	IDA	biological_process
GO:0050709	Negative regulation of protein secretion	IDA	biological_process
GO:0051209	Release of sequestered calcium ion into cytosol	IEA ISS	biological_process
GO:0051481	Negative regulation of cytosolic calcium ion concentration	IEA	biological_process
GO:0051482	Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway	IDA	biological_process
GO:0051584	Regulation of dopamine uptake involved in synaptic transmission	IC	biological_process
GO:0051586	Positive regulation of dopamine uptake involved in synaptic transmission	IEA ISS	biological_process
GO:0051823	Regulation of synapse structural plasticity	IEA	biological_process
GO:0051898	Negative regulation of protein kinase B signaling	IEA ISS	biological_process
GO:0051967	Negative regulation of synaptic transmission, glutamatergic	IEA ISS	biological_process
GO:0060124	Positive regulation of growth hormone secretion	IEA ISS	biological_process
GO:0060134	Prepulse inhibition	IEA ISS	biological_process
GO:0060158	Phospholipase C-activating dopamine receptor signaling pathway	IEA IGI	biological_process
GO:0060160	Negative regulation of dopamine receptor signaling pathway	IEA ISS	biological_process
GO:0070374	Positive regulation of ERK1 and ERK2 cascade	IEA	biological_process
GO:0090325	Regulation of locomotion involved in locomotory behavior	IEA	biological_process
GO:1900273	Positive regulation of long-term synaptic potentiation	IEA	biological_process
GO:1901386	Negative regulation of voltage-gated calcium channel activity	IDA IEA	biological_process

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4. Expression levels in datasets

Meta-analysis result

p-value up	p-value down	FDR up	FDR down
0.5034133430	0.9174264200	0.9999902473	1.0000000000

Individual experiment result
( "-" represent NA in the specific microarray platform )

Data source	Up or down	Log fold change
GSE11954	Down	-0.0895712130
GSE13712_SHEAR	Up	0.0594582353
GSE13712_STATIC	Up	0.0095607039
GSE19018	Up	0.0637215915
GSE19899_A1	Up	0.0367244063
GSE19899_A2	Up	0.1168979475
PubMed_21979375_A1	Down	-0.0321257492
PubMed_21979375_A2	Down	-0.1211840952
GSE35957	Up	0.2072325546
GSE36640	Up	0.0685458961
GSE54402	Up	0.0759266117
GSE9593	Down	-0.0477860069
GSE43922	Up	0.0422985453
GSE24585	Up	0.0629216855
GSE37065	Down	-0.0524454289
GSE28863_A1	Up	0.0004517128
GSE28863_A2	Up	0.0052710555
GSE28863_A3	Up	0.4460315661
GSE28863_A4	Up	0.0475398288
GSE48662	Up	0.1629857851

5. Regulation relationships with compounds/drugs/microRNAs

Compounds

Not regulated by compounds

Drugs

Not regulated by drugs

MicroRNAs

mirTarBase

No target information from mirTarBase

mirRecord

No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.

Navigator

1.General information
2.Neighbors in the network
3.Gene Ontology Annotation
4.Expression levels
5.Regulation
6.Text-mining results