HCSGD entry for DOCK1
1. General information
| Official gene symbol | DOCK1 |
|---|---|
| Entrez ID | 1793 |
| Gene full name | dedicator of cytokinesis 1 |
| Other gene symbols | DOCK180 ced5 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005085 | Guanyl-nucleotide exchange factor activity | IEA | molecular_function |
| GO:0005096 | GTPase activator activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | TAS | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006911 | Phagocytosis, engulfment | TAS | biological_process |
| GO:0006915 | Apoptotic process | IEA | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0007229 | Integrin-mediated signaling pathway | TAS | biological_process |
| GO:0007264 | Small GTPase mediated signal transduction | IEA | biological_process |
| GO:0007411 | Axon guidance | TAS | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0016020 | Membrane | IEA | cellular_component |
| GO:0016477 | Cell migration | IEA | biological_process |
| GO:0017124 | SH3 domain binding | IEA | molecular_function |
| GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis | TAS | biological_process |
| GO:0043085 | Positive regulation of catalytic activity | TAS | biological_process |
| GO:0043547 | Positive regulation of GTPase activity | TAS | biological_process |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0050790 | Regulation of catalytic activity | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3903343984 | 0.5629958854 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1031211171 |
| GSE13712_SHEAR | Up | 0.0375517516 |
| GSE13712_STATIC | Down | -0.1551331527 |
| GSE19018 | Up | 0.1096162193 |
| GSE19899_A1 | Up | 0.0064018227 |
| GSE19899_A2 | Up | 0.0768771142 |
| PubMed_21979375_A1 | Down | -0.0503188398 |
| PubMed_21979375_A2 | Up | 0.2676099052 |
| GSE35957 | Up | 0.1235417299 |
| GSE36640 | Up | 0.1940714420 |
| GSE54402 | Down | -0.1610295283 |
| GSE9593 | Up | 0.0816608030 |
| GSE43922 | Down | -0.5177827049 |
| GSE24585 | Up | 0.0087136505 |
| GSE37065 | Down | -0.1365190554 |
| GSE28863_A1 | Up | 0.9262115811 |
| GSE28863_A2 | Up | 0.5770180648 |
| GSE28863_A3 | Down | -0.2099272145 |
| GSE28863_A4 | Down | -0.0104480939 |
| GSE48662 | Down | -0.2503704739 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-296-3p | MIMAT0004679 | MIRT038422 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-183-5p | MIMAT0000261 | MIRT047082 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
