HCSGD entry for TRDMT1
1. General information
| Official gene symbol | TRDMT1 |
|---|---|
| Entrez ID | 1787 |
| Gene full name | tRNA aspartic acid methyltransferase 1 |
| Other gene symbols | DMNT2 DNMT2 MHSAIIP PUMET RNMT1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001975 | Response to amphetamine | IEA | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0003886 | DNA (cytosine-5-)-methyltransferase activity | TAS | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006306 | DNA methylation | IEA | biological_process |
| GO:0008168 | Methyltransferase activity | IEA | molecular_function |
| GO:0008175 | TRNA methyltransferase activity | IDA | molecular_function |
| GO:0030488 | TRNA methylation | IDA | biological_process |
| GO:0090116 | C-5 methylation of cytosine | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9838368033 | 0.0526205577 | 0.9999902473 | 0.4324290977 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1845487243 |
| GSE13712_SHEAR | Down | -0.1192755054 |
| GSE13712_STATIC | Down | -0.2669730394 |
| GSE19018 | Down | -0.1792575185 |
| GSE19899_A1 | Down | -0.0320019103 |
| GSE19899_A2 | Down | -0.5276110305 |
| PubMed_21979375_A1 | Up | 0.0084128999 |
| PubMed_21979375_A2 | Down | -0.5545107161 |
| GSE35957 | Down | -0.0025566933 |
| GSE36640 | Down | -0.5755972297 |
| GSE54402 | Down | -0.0318591087 |
| GSE9593 | Down | -0.0535474629 |
| GSE43922 | Down | -0.1007059019 |
| GSE24585 | Down | -0.4586333374 |
| GSE37065 | Down | -0.0816939862 |
| GSE28863_A1 | Up | 0.1206826771 |
| GSE28863_A2 | Up | 0.1817546115 |
| GSE28863_A3 | Down | -0.3449057335 |
| GSE28863_A4 | Up | 0.1168521970 |
| GSE48662 | Down | -0.3305152350 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26814705 | Furthermore, NP treatment induced the activation of Nrf2- and FOXO3A-mediated cellular stress responses, including an increased expression of heme oxygenease (HO-1), sirtuin (SIRT1), and DNA methyltransferase II (DNMT2) |
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