HCSGD entry for DYNC1H1
1. General information
| Official gene symbol | DYNC1H1 |
|---|---|
| Entrez ID | 1778 |
| Gene full name | dynein, cytoplasmic 1, heavy chain 1 |
| Other gene symbols | DHC1 DHC1a DNCH1 DNCL DNECL DYHC Dnchc1 HL-3 p22 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000086 | G2/M transition of mitotic cell cycle | TAS | biological_process |
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0003777 | Microtubule motor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005794 | Golgi apparatus | IDA | cellular_component |
| GO:0005813 | Centrosome | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005868 | Cytoplasmic dynein complex | NAS | cellular_component |
| GO:0005874 | Microtubule | IDA | cellular_component |
| GO:0006810 | Transport | IEA | biological_process |
| GO:0007018 | Microtubule-based movement | IEA | biological_process |
| GO:0007052 | Mitotic spindle organization | NAS | biological_process |
| GO:0008219 | Cell death | IEA | biological_process |
| GO:0016887 | ATPase activity | IEA | molecular_function |
| GO:0019886 | Antigen processing and presentation of exogenous peptide antigen via MHC class II | TAS | biological_process |
| GO:0033962 | Cytoplasmic mRNA processing body assembly | ISS | biological_process |
| GO:0034063 | Stress granule assembly | ISS | biological_process |
| GO:0070062 | Extracellular vesicular exosome | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0171228715 | 0.9547395920 | 0.3224007138 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0222678029 |
| GSE13712_SHEAR | Up | 0.1520214976 |
| GSE13712_STATIC | Up | 0.0958295994 |
| GSE19018 | Up | 0.2955814160 |
| GSE19899_A1 | Down | -0.0081441247 |
| GSE19899_A2 | Up | 0.0482615009 |
| PubMed_21979375_A1 | Down | -0.3797756997 |
| PubMed_21979375_A2 | Down | -0.1071007187 |
| GSE35957 | Up | 0.0832427152 |
| GSE36640 | Up | 0.3805441192 |
| GSE54402 | Up | 0.2277807972 |
| GSE9593 | Up | 0.2516355831 |
| GSE43922 | Down | -0.1492084694 |
| GSE24585 | Up | 0.1280879697 |
| GSE37065 | Down | -0.1463984738 |
| GSE28863_A1 | Up | 1.7210236370 |
| GSE28863_A2 | Up | 2.0986145690 |
| GSE28863_A3 | Up | 0.3820595530 |
| GSE28863_A4 | Up | 0.1166596044 |
| GSE48662 | Up | 0.1572188111 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-122-5p | MIMAT0000421 | MIRT023355 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-455-3p | MIMAT0004784 | MIRT037838 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040034 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-149-5p | MIMAT0000450 | MIRT045390 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT046872 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-96-5p | MIMAT0000095 | MIRT048724 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049178 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052059 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
