HCSGD entry for DNASE1
1. General information
| Official gene symbol | DNASE1 |
|---|---|
| Entrez ID | 1773 |
| Gene full name | deoxyribonuclease I |
| Other gene symbols | DNL1 DRNI |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003779 | Actin binding | IEA | molecular_function |
| GO:0004530 | Deoxyribonuclease I activity | IEA | molecular_function |
| GO:0004536 | Deoxyribonuclease activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | IEA | cellular_component |
| GO:0005635 | Nuclear envelope | IEA | cellular_component |
| GO:0006915 | Apoptotic process | IEA | biological_process |
| GO:0016888 | Endodeoxyribonuclease activity, producing 5'-phosphomonoesters | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5259946583 | 0.9305148247 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0109072601 |
| GSE13712_SHEAR | Up | 0.1203139408 |
| GSE13712_STATIC | Up | 0.0435315733 |
| GSE19018 | Up | 0.1086335751 |
| GSE19899_A1 | Up | 0.0719658986 |
| GSE19899_A2 | Up | 0.0506680852 |
| PubMed_21979375_A1 | Down | -0.1145608097 |
| PubMed_21979375_A2 | Down | -0.0201323602 |
| GSE35957 | Down | -0.0300949689 |
| GSE36640 | Up | 0.5264563437 |
| GSE54402 | Up | 0.0141631370 |
| GSE9593 | Up | 0.0933167294 |
| GSE43922 | Up | 0.0438590815 |
| GSE24585 | Up | 0.2809121470 |
| GSE37065 | Down | -0.0825532215 |
| GSE28863_A1 | Up | 0.0699278867 |
| GSE28863_A2 | Down | -0.0906870079 |
| GSE28863_A3 | Up | 0.0026364601 |
| GSE28863_A4 | Down | -0.0224332646 |
| GSE48662 | Up | 0.0813589225 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 6224986 | The effects of histones, in vitro age, and culture state on the digestion of DNA by micrococcal nuclease and deoxyribonuclease I |
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