HCSGD entry for AGER
1. General information
| Official gene symbol | AGER |
|---|---|
| Entrez ID | 177 |
| Gene full name | advanced glycosylation end product-specific receptor |
| Other gene symbols | RAGE |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004872 | Receptor activity | TAS | molecular_function |
| GO:0004888 | Transmembrane signaling receptor activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | IEA | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
| GO:0006954 | Inflammatory response | IEA | biological_process |
| GO:0007166 | Cell surface receptor signaling pathway | TAS | biological_process |
| GO:0009611 | Response to wounding | TAS | biological_process |
| GO:0016020 | Membrane | IEA | cellular_component |
| GO:0031175 | Neuron projection development | IGI | biological_process |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
| GO:0044548 | S100 protein binding | IPI | molecular_function |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0050930 | Induction of positive chemotaxis | IEA | biological_process |
| GO:0051092 | Positive regulation of NF-kappaB transcription factor activity | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8220663045 | 0.6557679154 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1618545517 |
| GSE13712_SHEAR | Down | -0.0978238946 |
| GSE13712_STATIC | Down | -0.0562396343 |
| GSE19018 | Up | 0.0523832672 |
| GSE19899_A1 | Up | 0.0025686419 |
| GSE19899_A2 | Up | 0.1073993886 |
| PubMed_21979375_A1 | Down | -0.3257913608 |
| PubMed_21979375_A2 | Up | 0.0750182899 |
| GSE35957 | Up | 0.0498212897 |
| GSE36640 | Down | -0.0151186116 |
| GSE54402 | Down | -0.1439180774 |
| GSE9593 | Up | 0.1404799579 |
| GSE43922 | Up | 0.1180170550 |
| GSE24585 | Down | -0.1842021839 |
| GSE37065 | Up | 0.0832532618 |
| GSE28863_A1 | Up | 0.0576334880 |
| GSE28863_A2 | Up | 0.0435768706 |
| GSE28863_A3 | Up | 0.0722288987 |
| GSE28863_A4 | Up | 0.0538115804 |
| GSE48662 | Down | -0.0129255314 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-195-5p | MIMAT0000461 | MIRT044860 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-10a-5p | MIMAT0000253 | MIRT047532 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT051103 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
