HCSGD entry for DNAH8
1. General information
| Official gene symbol | DNAH8 |
|---|---|
| Entrez ID | 1769 |
| Gene full name | dynein, axonemal, heavy chain 8 |
| Other gene symbols | ATPase hdhc9 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001539 | Ciliary or bacterial-type flagellar motility | NAS | biological_process |
| GO:0003777 | Microtubule motor activity | IEA NAS | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005858 | Axonemal dynein complex | NAS | cellular_component |
| GO:0005874 | Microtubule | IEA | cellular_component |
| GO:0007018 | Microtubule-based movement | IEA | biological_process |
| GO:0008152 | Metabolic process | NAS | biological_process |
| GO:0016887 | ATPase activity | IEA | molecular_function |
| GO:0030286 | Dynein complex | IEA | cellular_component |
| GO:0031514 | Motile cilium | IEA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7753656168 | 0.7930608791 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0061107094 |
| GSE13712_SHEAR | Down | -0.0837246079 |
| GSE13712_STATIC | Down | -0.1524504617 |
| GSE19018 | Down | -0.0911919488 |
| GSE19899_A1 | Up | 0.1386461286 |
| GSE19899_A2 | Down | -0.1301251585 |
| PubMed_21979375_A1 | Up | 0.2631126400 |
| PubMed_21979375_A2 | Down | -0.0609354012 |
| GSE35957 | Down | -0.0157732732 |
| GSE36640 | Up | 0.0046278713 |
| GSE54402 | Up | 0.0389018473 |
| GSE9593 | Up | 0.0980935829 |
| GSE43922 | Up | 0.0174332408 |
| GSE24585 | Up | 0.1695986278 |
| GSE37065 | Down | -0.0095231330 |
| GSE28863_A1 | Down | -0.0026925952 |
| GSE28863_A2 | Down | -0.0053862982 |
| GSE28863_A3 | Up | 0.0858612147 |
| GSE28863_A4 | Down | -0.0306142922 |
| GSE48662 | Up | 0.2869290317 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-19b-1-5p | MIMAT0004491 | MIRT038978 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 16 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27245197 | To achieve this objective activities of membrane linked Na+/K + ATPase (NKA), Na+/H+ exchanger (NHE) and correlation with membrane hydrxyperoxide level, sialic acid content and membrane protein oxidation was studied in density-gradient fractionated young and old erythrocytes from 4 and 24 month old Wistar rats |
| 27197071 | Each of these lysosomal behaviors is influenced by the intraluminal pH of the lysosome, which is maintained in the low acidic range by a proton pump, the vacuolar ATPase (v-ATPase) |
| 26171229 | Reduced activity of SKC a and Na-K ATPase underlies the accelerated impairment of EDH-type relaxations in mesenteric arteries of aging spontaneously hypertensive rats |
| 26171229 | EDH-type relaxations in WKY were reduced with aging, and this was associated with an impairment of the function of small-conductance calcium-activated potassium channels (SKC a) and sodium-potassium ATPase (Na-K ATPase) |
| 26171229 | Pharmacological experiments suggested a reduced involvement of SKC a and Na-K ATPase and activation of adenosine monophosphate-activated protein kinase and silent information regulator T1 (sirtuin-1; SIRT1) in mesenteric arteries of 12-week-old SHR |
| 26171229 | The latter exacerbation appears to involve proteins associated with the process of cellular senescence and is related to impaired function of SKC a and Na-K ATPase, a phenomenon that is also observed in mesenteric arteries of older normotensive rats |
| 25152327 | The iTRAQ quantitative data revealed significant up-regulation of protein-l-isoaspartate O-methyltransferase and sodium-potassium transporting ATPase, while post-translational modification analysis suggested deamidation of catalytic and regulatory subunits of sodium-potassium transporting ATPase |
| 25152327 | Structural modeling of sodium-potassium transporting ATPase revealed the close proximity of these deamidated residues to the catalytic site during E2P confirmation |
| 23146670 | Decline of p400 ATPase in senescent IMR-90 cells prompted us to investigate structural changes in the chromatin of the p21 promoter during in vitro aging |
| 22341977 | OBJECTIVES: Reptin is an AAA+ ATPase associated with several complexes involved in chromatin remodeling, transcriptional regulation, DNA damage repair, and telomerase activity |
| 21763315 | Using SILAC-proteomic analysis and molecular studies, we identified the AAA+ ATPase, RuvBl2 as a transcriptional regulator of hTERT and established that this regulation is through cooperation with Ets-2 |
| 20697355 | The BRG1 ATPase of chromatin remodeling complexes is involved in modulation of mesenchymal stem cell senescence through RB-P53 pathways |
| 20501696 | Here, we show that MORC3 colocalizes with PML by a two-step molecular mechanism: the PML-independent formation of MORC3 NDs by the ATPase cycle, and the association of MORC3 with PML via the SUMO1-SUMO-interacting motif (SIM) |
| 17334838 | Overexpression of Na(+)/K (+)-ATPase parallels the increase in sodium transport and potassium recycling in an in vitro model of proximal tubule cellular ageing |
| 16720342 | WRN possesses multiple DNA-dependent enzymatic activities (ATPase, helicase, exonuclease, and strand annealing) and interacts with factors having established roles in DNA metabolic pathways |
| 9593315 | Among the clones, we identified four distinct mitochondrial genes including NADH dehydrogenase subunit 2 (ND2), ND3, ATPase 6 and 16S ribosomal RNA |
| 9593315 | Northern blot and slot blot hybridization confirmed that the expression levels of ND3, ATPase 6 and 16S rRNA were elevated in senescent cells of all four strains |
| 1833624 | The plasma membrane Ca2+ ATPase in erythrocytes is vital for the maintenance of intracellular Ca2+ levels |
| 1833624 | Since the cytoplasmic Ca2+ concentration is elevated in older erythrocytes, the properties of the Ca2+ transport ATPase were examined during cell aging using inside-out vesicles (IOVs) prepared from density-separated, young (less dense, Ey) and old (more dense, Eo) rat and human erythrocytes |
| 2782845 | No changes were found with ageing in inner mitochondrial membrane-associated matrix components, or in the activities of O-S ATPase and MDH |
| 378256 | Ouabain and anoxia have no effect on K+ transport mechanisms; in contrast, both processes are completely blocked by dicyclohexylcarbodiimide, an inhibitor of the Mg2+ -dependent ATPase activity |
| 16660789 | Plasma membranes from abscission zones of kidney bean seedlings were isolated on sucrose density gradients using cellulase and KCl-stimulated ATPase as marker enzymes |
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